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Your search keyword '"Hongrui Cui"' showing total 2 results
Start Over Author "Hongrui Cui" Journal veterinary research
2 results on '"Hongrui Cui"'

1. Pathogenicity of reassortant H9 influenza viruses with different NA genes in mice and chickens.

Author

Liping Yan, Qinfang Liu, Xin Su, Qiaoyang Teng, Danqi Bao, Guangsheng Che, Hongjun Chen, Hongrui Cui, Tao Ruan, Xuesong Li, and Zejun Li

Abstract

To better understand the influence of different NA genes on pathogenicity of H9 viruses, three reassortant H9 viruses (rH9N1, H9N2 and rH9N3) were generated and characterized. All three viruses replicated efficiently in eggs and MDCK cells, whereas the rH9N1 and rH9N3 replicated more efficiently than H9N2 in A549 cells. The rH9N3 replicated more efficiently than rH9N1 and H9N2 viruses in mice, however, rH9N3 replicated and shed less efficiently than the H9N2 virus in chickens. Further studies indicate that N3 had higher NA activity and released virus from erythrocytes faster, which may improve the adaptation of H9 influenza virus to mammals. [ABSTRACT FROM AUTHOR]

Published
2016
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2. Pathogenicity of reassortant H9 influenza viruses with different NA genes in mice and chickens

Author

Qiaoyang Teng, Zejun Li, Guangsheng Che, Liping Yan, Danqi Bao, Tao Ruan, Hongrui Cui, Xin Su, Xuesong Li, Hongjun Chen, and Qinfang Liu

Subjects
0301 basic medicine, Genes, Viral, [SDV]Life Sciences [q-bio], animal diseases, viruses, Short Report, Neuraminidase, Virus Replication, medicine.disease_cause, Virus, Madin Darby Canine Kidney Cells, Microbiology, Mice, 03 medical and health sciences, Dogs, Orthomyxoviridae Infections, Influenza A Virus, H9N2 Subtype, Influenza A virus, medicine, Animals, Gene, A549 cell, Mice, Inbred BALB C, General Veterinary, biology, Madin Darby canine kidney cell, food and beverages, virus diseases, Pathogenicity, Virology, veterinary(all), 3. Good health, 030104 developmental biology, Viral replication, A549 Cells, Influenza in Birds, biology.protein, Chickens
Abstract

International audience; AbstractTo better understand the influence of different NA genes on pathogenicity of H9 viruses, three reassortant H9 viruses (rH9N1, H9N2 and rH9N3) were generated and characterized. All three viruses replicated efficiently in eggs and MDCK cells, whereas the rH9N1 and rH9N3 replicated more efficiently than H9N2 in A549 cells. The rH9N3 replicated more efficiently than rH9N1 and H9N2 viruses in mice, however, rH9N3 replicated and shed less efficiently than the H9N2 virus in chickens. Further studies indicate that N3 had higher NA activity and released virus from erythrocytes faster, which may improve the adaptation of H9 influenza virus to mammals.

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