11 results on '"Penny J. Regier"'
Search Results
2. Otoscopic evaluation of epithelial remnants in the tympanic cavity after total ear canal ablation and lateral bulla osteotomy
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Penny J. Regier, Meghan M. Watt, Judith Bertran, W. Alexander Fox-Alvarez, Marina J. McConkey, and C. R. A. Ferrigno
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Ablation Techniques ,Endoscope ,040301 veterinary sciences ,medicine.medical_treatment ,Ear, Middle ,Otoscopy ,Epithelium ,0403 veterinary science ,03 medical and health sciences ,Dogs ,0302 clinical medicine ,Cadaver ,medicine ,Animals ,Tympanic cavity ,Dog Diseases ,Ear canal ,Compartment (pharmacokinetics) ,General Veterinary ,medicine.diagnostic_test ,business.industry ,04 agricultural and veterinary sciences ,Anatomy ,Otitis Externa ,Ablation ,Curettage ,Osteotomy ,Endoscopy ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,business ,Ear Canal - Abstract
Objective To determine the ability to detect the presence of epithelial remnants after total ear canal ablation (TECA) and lateral bulla osteotomy (LBO) with endoscopy and to identify the most common locations of epithelial remnants after tympanic curettage. Study design Experimental study. Animals Five fresh canine cadavers with no gross evidence of middle ear disease. Methods Ten TECA-LBO were performed by four surgeons. After tympanic curettage, a 1.9-mm rigid 30° endoscope was inserted into the rostral, caudal, dorsal, ventral, and medial sections of the tympanic cavity. Three observers evaluated otoscopic images for epithelial remnants in each compartment. The median distribution of epithelial remnants was calculated for each section of the tympanic cavity with a three-dimensional tympanic cavity model. Results Epithelial remnants were identified in at least one of the five areas of the tympanic cavity after each TECA-LBO. The rostral section contained the most epithelial remnants (35.6%), while the medial section contained the least amount (1.8%). Conclusion Use of a 1.9-mm rigid endoscope was an effective method to evaluate all sections of the tympanic cavity after curettage in TECA-LBO. Epithelial remnants were consistently found after TECA-LBO, especially in the rostral compartment. Clinical significance Intraoperative endoscopy should be considered to improve removal of epithelium after initial TECA-LBO or revision surgeries.
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- 2020
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3. Gastrointestinal thickness, duration, and leak pressure of six intestinal anastomoses in dogs
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W. Alexander Fox-Alvarez, James Colee, Penny J. Regier, Monica Waln, and Kaitlyn M. Mullen
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Leak ,040301 veterinary sciences ,Operative Time ,Ileum ,Anastomosis ,0403 veterinary science ,Jejunum ,03 medical and health sciences ,Dogs ,0302 clinical medicine ,Suture (anatomy) ,Cadaver ,Pressure ,medicine ,Animals ,Digestive System Surgical Procedures ,Peristalsis ,Sutures ,General Veterinary ,business.industry ,Stomach ,Anastomosis, Surgical ,Suture Techniques ,04 agricultural and veterinary sciences ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Duodenum ,Nuclear medicine ,business - Abstract
Objective To compare leak pressures and construct completion time of six intestinal anastomoses and report normal canine gastrointestinal thickness. Study design Experimental study. Animals Grossly normal jejunal segments (n = 140) from 10 fresh canine cadavers. Methods Gastrointestinal thickness was recorded. Eight-centimeter cooled canine cadaveric jejunal segments were randomly assigned to a control group (20 segments) and six treatment groups (20 segments/group [10 constructs/group]): (1) handsewn anastomosis (HSA), (2) functional end-to-end stapled anastomosis (FEESA)-blue thoracoabdominal (TA; FEESA-TAB), (3) FEESA-green TA (FEESA-TAG), (4) FEESA TA-gastrointestinal anastomosis (GIA), (5) FEESA with suture oversew (FEESA-O), and (6) skin staples (SS). Construct assembly time, initial leak pressure (ILP), maximum intraluminal pressure (MIP), and leakage location were compared. Results Initial leak pressures (mean ± SD) for control (308.38 ± 115.91 mm Hg), HSA (41.96 ± 15.97), FEESA-TAB (31.71 ± 15.71), FEESA-TAG (27.24 ± 14.11), FEESA-GIA (25.62 ± 11.22), FEESA-O (31.01 ± 17.38), and SS (44.42 ± 28.88) groups were compared. No difference in ILP (P > .24) or MIP (P > .17) was detected between treatment groups. Sutured anastomoses took up to 10 times longer to complete (P = .0025). The stomach, duodenum, jejunum, and ileum mural thicknesses (mean ± SD) were 3.99 ± 0.44 mm, 2.34 ± 0.16, 2.49 ± 0.28, and 2.30 ± 0.31, respectively. Conclusion The ILP of all anastomoses exceeded maximum intraluminal peristaltic pressures. Stapled anastomoses were faster to complete. Clinical significance All anastomoses may be considered when performing an intestinal resection and anastomosis, with stapled anastomoses resulting in a shorter surgical time. Canine intestinal thickness may warrant use of a larger staple size.
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- 2020
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4. In vitro holding strength of the laparoscopic Miller's knot compared with open Miller's knot, open surgeon's throw, and laparoscopic surgeon's throw in a vascular pedicle model
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Andrea K. Erickson, W. Alexander Fox-Alvarez, Penny J. Regier, and J. Brad Case
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medicine.medical_specialty ,Sutures ,General Veterinary ,Vascular pedicle ,business.industry ,Suture Techniques ,Box trainer ,food and beverages ,Polyglyconate suture ,In Vitro Techniques ,Surgery ,surgical procedures, operative ,Knot (unit) ,stomatognathic system ,Tensile Strength ,medicine ,Balloon dilation ,Laparoscopy ,business ,Ligation - Abstract
OBJECTIVE To compare in vitro knot holding strength of the laparoscopic Miller's knot (LMK), open Miller's knot (MK), open surgeon's throw (Sx), and laparoscopic surgeon's throw (LSx) in a vascular pedicle model when used as the first throw for vascular ligation. STUDY DESIGN Experimental study. SAMPLE POPULATION Ten constructs each of the Miller's knot and surgeon's throw performed openly and laparoscopically with 2-0 polyglyconate suture. METHODS Knot holding strengths of the LMK, MK, LSx, and Sx knots were evaluated on balloon dilation catheters used as vascular pedicle models. Laparoscopic knots were tied in a laparoscopic box trainer. Knot constructs were pressure tested to failure. Results were compared by Kruskal-Wallis and Steel-Dwass comparisons. RESULTS Both MK and LMK had mean leakage pressures above 300 mm Hg. The MK leaked at higher pressure than all other knots, including the LMK (P
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- 2020
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5. Clinical findings and outcomes of 153 dogs surgically treated for intestinal intussusceptions
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Kelley M. Thieman Mankin, Penny J. Regier, Galina M. Hayes, Janet A. Grimes, James Franklin Moyer, Jeffrey J. Runge, Michelle A. Giuffrida, Shiori Arai, Chiara Curcillo, Philipp D. Mayhew, Philippe Chagnon Larose, Ross Bernstein, Ameet Singh, Julius M. Liptak, Christopher G Dominic, Charles W. Bruce, Mathieu Gatineau, Christopher B. Thomson, and J. Brad Case
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Male ,medicine.medical_specialty ,040301 veterinary sciences ,Peritonitis ,Anastomosis ,0403 veterinary science ,03 medical and health sciences ,Dogs ,Postoperative Complications ,0302 clinical medicine ,Recurrence ,Interquartile range ,Intussusception (medical disorder) ,Animals ,Medicine ,Clinical significance ,Dog Diseases ,Intraoperative Complications ,Digestive System Surgical Procedures ,Retrospective Studies ,General Veterinary ,business.industry ,Medical record ,Anastomosis, Surgical ,Retrospective cohort study ,04 agricultural and veterinary sciences ,Perioperative ,medicine.disease ,Surgery ,030220 oncology & carcinogenesis ,Female ,business ,Intussusception - Abstract
Objective To describe perioperative characteristics and outcomes of dogs surgically treated for intestinal intussusception. Study design Multi-institutional, retrospective study. Animals One hundred fifty-three client-owned dogs with intestinal intussusception. Methods Dogs were included when they had undergone surgical treatment of a confirmed intestinal intussusception. Medical records were reviewed for demographics and clinical data, including surgical complications (graded 1-4). Follow-up was obtained via telephone interview with owners and referring veterinarians. Results Dogs had a median age of 10 months (range, 2-156), and the most common location for intussusception was ileocolic (66/153 [43%]). Most cases had no identifiable cause (104/155 [67%]). Intestinal resection and anastomosis (IRA) was performed in 129 of 153 (84%) dogs; enteroplication was performed in 28 of 153 (18%) dogs, including 13 with and 15 without IRA. Intraoperative complications occurred in 10 of 153 (7%) dogs, all involving intestinal damage during attempted manual reduction. The median duration of follow-up after discharge was 334 days (interquartile range, 15-990; range, 1-3302). Postoperative complications occurred in 53 of 153 (35%) dogs, including 22 of 153 (14%) with severe (grade 3 or 4) events. Diarrhea, regurgitation, and septic peritonitis were the most common postoperative complications; intussusception recurred in four of 153 (3%) dogs, all within 72 hours postoperatively. Fourteen-day postoperative mortality rate was 6%. Conclusion Surgical treatment of intestinal intussusception was curative in most dogs, even when an underlying cause was not identified. Surgical complications were common, including a 14% risk of life-threatening short-term complications. Clinical significance Surgical treatment of intestinal intussusception offers an excellent prognosis, but the potential life-threatening complications should be considered.
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- 2020
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6. Initial leak pressures of four anastomosis techniques in cooled cadaveric canine jejunum
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Fernando L Garcia-Pereira, Mark J. Fealey, Penny J. Regier, Charles Steadman Bs, and J. Brad Case
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Leak ,040301 veterinary sciences ,Anastomosis ,Surgical methods ,0403 veterinary science ,Jejunum ,Random Allocation ,03 medical and health sciences ,Dogs ,0302 clinical medicine ,Cadaver ,Pressure ,medicine ,Animals ,Digestive System Surgical Procedures ,General Veterinary ,business.industry ,Anastomosis, Surgical ,Suture Techniques ,04 agricultural and veterinary sciences ,Intestinal anastomosis ,Cold Temperature ,medicine.anatomical_structure ,Barbed suture ,030220 oncology & carcinogenesis ,Cadaveric spasm ,Nuclear medicine ,business - Abstract
Objective To compare the effectiveness of four different intestinal anastomosis techniques at preventing leakage after enterectomy. Study design Experimental study. Sample population Grossly normal jejunal segments (N = 70) from three fresh canine cadavers. Methods Eight-centimeter cooled canine cadaveric jejunal segments were randomly assigned to a control group (six segments) and four treatment groups (16 segments each [two segments/anastomotic construct]): (1) handsewn anastomosis (HSA), (2) barbed suture anastomosis (B-HSA), (3) stapled functional end-to-end anastomosis (SFEEA), and (4) stapled functional end-to-end anastomosis with an oversew (SFEEA-O). Control segments and anastomotic constructs were infused intraluminally to the point of leakage. Initial leak pressures were recorded and compared. Results Initial leak pressures (median + range) for jejunal control segments, HSA, B-HSA, SFEEA, and SFEEA-O were 331.88 mmHg (range, 315.34-346.64), 35.17 (20.29-56.24), 24.99 (6.08-38.64), 28.77 (18.80-85.09), and 35.92 (12.05-80.71), respectively. No difference was detected between leak pressures of anastomosed segments (P = .35), all of which were more variable and lower than those of intact segments. Conclusion No difference in initial leak pressures was detected between the four anastomosis techniques tested in cooled canine cadaveric jejunum. Clinical significance All four anastomosis techniques evaluated in this study may be suitable in dogs.
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- 2020
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7. Vascular ring anomalies in cats: 20 cases (2000‐2018)
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Ameet Singh, Kathleen Ham, Penny J. Regier, James A. Flanders, J. Brad Case, Ana Luisa Bascuñán, Kelley Thieman-Mankin, and Ingrid M. Balsa
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Male ,medicine.medical_specialty ,040301 veterinary sciences ,Cardiovascular Abnormalities ,Subclavian Artery ,Cat Diseases ,0403 veterinary science ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Animals ,Abnormalities, Multiple ,Medical history ,Clinical significance ,Survival rate ,Retrospective Studies ,CATS ,General Veterinary ,business.industry ,Medical record ,Megaesophagus ,Vascular ring ,Retrospective cohort study ,04 agricultural and veterinary sciences ,medicine.disease ,Vascular Ring ,Surgery ,030220 oncology & carcinogenesis ,Cats ,Female ,business - Abstract
Objective To report the clinical characteristics, types of vascular ring anomalies (VRA), operative findings, complications, and survival after surgical treatment of cats with VRA. Study design Retrospective, multi-institutional case series. Animals Client- or shelter-owned cats presenting to academic, referral veterinary institutions. Methods Medical records of cats with VRA that underwent surgical treatment were reviewed. Signalment, relevant medical history, clinical signs, diagnostic imaging, surgical findings, complications, and survival were recorded. Results Twenty cats with VRA were included. Vascular ring anomalies were most commonly (75% [15/20]) diagnosed in cats less than 1 year old, with no breed or sex predilection. Regurgitation was the most common clinical sign, present in 18 of 20 (90%) cats. A persistent right aortic arch was diagnosed in 17 of 20 (85%) cats, with concurrent aberrant left subclavian artery in four of the cats. Surgical treatment was associated with survival to discharge in 18 of 20 (90%) cats. Persistent clinical signs were reported in nine of 13 (69%) cats, and radiographic evidence of megaesophagus persisted in four of 13 (31%) cats, with a median follow-up of 275 days after discharge. Conclusion Persistent right aortic arch was the most commonly diagnosed VRA in cats in this series, although multiple anomalies were observed. Surgical treatment of VRA in cats was associated with a high survival to discharge, although persistence of clinical signs and megaesophagus was noted in 69% and 31% of the cats, respectively. Clinical significance Surgical treatment of VRA in cats is associated with a high survival rate; however, persistence of clinical signs is an expected outcome.
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- 2019
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8. Intestinal surgery in small animals: historical foundations, current thinking, and future horizons
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Gary W. Ellison, Penny J. Regier, and J. Brad Case
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medicine.medical_specialty ,040301 veterinary sciences ,Anastomosis ,Dehiscence ,Enterotomy ,0403 veterinary science ,Sepsis ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Suture (anatomy) ,medicine ,Animals ,Hypoalbuminemia ,Digestive System Surgical Procedures ,General Veterinary ,business.industry ,Suture Techniques ,04 agricultural and veterinary sciences ,medicine.disease ,Surgery ,Intestinal Diseases ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Abdomen ,Cadaveric spasm ,business - Abstract
Intestinal wounds require precise closure after intestinal biopsy, enterotomy, or enterectomy in small animals. Preexisting factors such as intra-abdominal sepsis and hypoalbuminemia as well as poor surgical technique increase the risk of intestinal dehiscence, with considerable negative impact on patient morbidity and mortality. Live dog studies have demonstrated the dangers of mucosal eversion especially in the septic abdomen. Approximating patterns preserve luminal diameter, heal optimally, and have equal bursting strength compared with inverting patterns after 24 hours. Simple interrupted and simple continuous suture patterns and disposable skin staples are established alternatives for manual wound closure. Knotless quilled suture currently used in laparoscopic gastropexy techniques shows bursting strength equal to monofilament sutures in dog cadaveric intestine. Dehiscence rates with hand sewn vs titanium automated stapling anastomosis are similar in uncomplicated cases; however, auto stapling devices may be the preferred method of anastomosis when preexisting abdominal sepsis is present and when patient size allows it. Regardless of the technique, current standard of care involves leak testing and omental wrapping, followed by early postoperative feeding. The past decade has ushered in an exciting new era of laparoscopic assisted techniques that have the potential to reduce postoperative pain and patient morbidity. An understanding of these applications will establish the future of minimally invasive small animal intestinal surgery for veterinary specialists. In summary, surgeons have a variety of methods at their disposal for optimal clinical outcome in small animal intestinal surgery.
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- 2019
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9. Feasibility of laparoscopic liver lobectomy in dogs
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J. Brad Case, Philipp D. Mayhew, Jeffrey J. Runge, Federico Massari, Aleisha E. Michael, Michelle A. Giuffrida, Jose L. Carvajal, Penny J. Regier, and Ameet Singh
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medicine.medical_specialty ,Adenoma ,040301 veterinary sciences ,medicine.medical_treatment ,Biliary Cyst ,0403 veterinary science ,03 medical and health sciences ,Liver disease ,Dogs ,0302 clinical medicine ,Interquartile range ,Cadaver ,Laparotomy ,medicine ,Animals ,Hepatectomy ,Dog Diseases ,General Veterinary ,business.industry ,Liver Neoplasms ,04 agricultural and veterinary sciences ,medicine.disease ,Surgery ,Liver ,Liver Lobe ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Feasibility Studies ,Laparoscopy ,business - Abstract
Objective To determine the feasibility of laparoscopic liver lobectomy (LLL) in dogs by using canine cadavers and to describe the clinical application in dogs with liver disease. Study design Ex vivo experiment and descriptive case series. Sample population Twelve canine cadavers and six client-owned dogs. Methods Cadavers underwent LLL with an endoscopic stapler. The percentage of liver lobe resected was determined by volume. The distance from the staple line to hilus was measured. Medical records of dogs undergoing LLL were reviewed. Results In cadavers ≤15 kg, left lateral lobectomy completeness was 87.3% (84.6%-96.6%), and remaining median (interquartile range) hilar length was 1 cm (0.25-1.75). Left medial lobectomy completeness was 72.5% (66.7%-80%), and remaining hilar length was 1.6 cm (0.47-1.75). Central division resection completeness was 68.3% (60%-92.9%), and remaining hilar length was 2.7 cm (0.8-5). Laparoscopic liver lobectomy was not feasible for right division lobes and in cadavers >15 kg. Five dogs with peripheral quadrate or left lateral lobe masses underwent stapled, partial laparoscopic lobectomy (30%-90%). One dog underwent stapled, left lateral lobectomy (90%) after open procedure conversion. Histopathological diagnoses included hepatocellular carcinoma (3), nodular hyperplasia (1), biliary cyst adenoma (1), and fibrosis (1). Conclusion Laparoscopic liver lobectomy of the left and central divisions is feasible in cadavers ≤15 kg with an endoscopic stapler. Partial LLL of the left and central divisions is feasible in select dogs with liver disease. Clinical significance Laparoscopic liver lobectomy may be a viable alternative to laparotomy in small-to-medium size dogs with peripheral liver masses of the left and central divisions.
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- 2021
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10. Ligation of the ligamentum arteriosum and aberrant left subclavian artery in five dogs in which persistent right aortic arch had been diagnosed
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J. Brad Case, Penny J. Regier, and W. Alexander Fox-Alvarez
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medicine.medical_specialty ,Surgical approach ,General Veterinary ,Ligamentum arteriosum ,medicine.diagnostic_test ,040301 veterinary sciences ,Aberrant left subclavian artery ,business.industry ,medicine.medical_treatment ,04 agricultural and veterinary sciences ,Regurgitation (circulation) ,Surgery ,0403 veterinary science ,03 medical and health sciences ,0302 clinical medicine ,Persistent right aortic arch ,030220 oncology & carcinogenesis ,medicine.ligament ,medicine ,Thoracoscopy ,Thoracotomy ,Ligation ,business - Abstract
Objective To determine and report the diagnosis, treatment, and outcome in dogs with persistent right aortic arch (PRAA) with an aberrant left subclavian artery (ALS) that underwent thoracoscopic surgery. Animals Dogs with PRAA and an ALS (n = 5). Study design Short case series. Methods Medical records were reviewed from 2014 to 2019. Dogs that underwent thoracoscopy for PRAA with an ALS at an academic referral hospital were included. Signalment, clinical signs, diagnostic imaging, surgical approach, complications, and short- and long-term outcomes were recorded. Results Persistent right aortic arch with an ALS was identified in five dogs. Dogs initially underwent a three-port intercostal thoracoscopic approach, and an intercostal thoracotomy was performed in converted cases. In all five dogs, the ligamentum arteriosum (LA) and ALS were divided; three were performed by a thoracoscopy alone. Two cases were converted because of poor exposure (1) and requirement to temporary occlude an ALS (1). The ALS was ligated and divided in all dogs without apparent negative effects. No intraoperative or postoperative complications occurred. Four dogs had resolution of regurgitation, three of which required diet modification. One dog had reported regurgitation when it was excited. Median follow-up was 188 days (range, 150-1133). Conclusion Ligation and division of both the LA and the ALS in all dogs in this case series was safe and allowed for improvement in clinical signs and good to excellent long-term outcomes. In addition, both thoracoscopy and thoracotomy were used safely and successfully for ligation and transection of the LA and ALS in all dogs.
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- 2021
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11. Frequency of Dehiscence in Hand-Sutured and Stapled Intestinal Anastomoses in Dogs
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Jill K. Luther, Jessica J. Leeman, Mark C. Rochat, Jason R. Duell, Christine M. Budke, Michael Mison, Kelley M. Thieman Mankin, Ameet Singh, and Penny J. Regier
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medicine.medical_specialty ,General Veterinary ,040301 veterinary sciences ,business.industry ,Significant difference ,Peritonitis ,04 agricultural and veterinary sciences ,Anastomosis ,Dehiscence ,medicine.disease ,Confidence interval ,Resection ,Surgery ,0403 veterinary science ,Surgical Wound Dehiscence ,03 medical and health sciences ,0302 clinical medicine ,Anesthesia ,medicine ,030211 gastroenterology & hepatology ,business ,Cohort study - Abstract
Objective To determine the frequency of dehiscence of hand-sutured and stapled intestinal anastomoses in the dog and compare the surgery duration for the methods of anastomosis. Study Design Historical cohort study. Sample Population Two hundred fourteen client-owned dogs undergoing hand-sutured (n = 142) or stapled (n = 72) intestinal anastomoses. Methods Medical records from 5 referral institutions were searched for dogs undergoing intestinal resection and anastomosis between March 2006 and February 2014. Demographic data, presence of septic peritonitis before surgery, surgical technique (hand-sutured or stapled), surgery duration, surgeon (resident versus faculty member), indication for surgical intervention, anatomic location of resection and anastomosis, and if dehiscence was noted postoperatively were retrieved. Estimated frequencies were summarized and presented as proportions and 95% confidence intervals (CI) and continuous outcomes as mean (95% CI). Comparisons were made across methods of anastomosis. Results Overall, 29/205 dogs (0.14, 95% CI 0.10–00.19) had dehiscence, including 21/134 dogs (0.16, 0.11–0.23) undergoing hand-sutured anastomosis and 8/71 dogs (0.11, 0.06–0.21) undergoing stapled anastomosis. There was no significant difference in the frequency of dehiscence across anastomosis methods (χ2, P = .389). The mean (95% CI) surgery duration of 140 minutes (132–147) for hand- sutured anastomoses and 108 minutes (99–119) for stapled anastomoses was significantly different (t-test, P
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- 2016
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