1. Genetic mutations in influenza H3N2 viruses from a 2012 epidemic in Southern China
- Author
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Lirong Zou, Ping Huang, Lijun Liang, Jin Yan, Jing Zhong, Shouyi Yu, Xin Zhang, Xiaolan Zhu, Hanzhong Ni, and Yonghui Zhang
- Subjects
China ,Genotype ,Molecular Sequence Data ,Neuraminidase ,Epidemic ,Hemagglutinin (influenza) ,Hemagglutinin Glycoproteins, Influenza Virus ,Biology ,medicine.disease_cause ,Antigenic drift ,Viral Proteins ,Phylogenetics ,Virology ,Influenza, Human ,medicine ,Cluster Analysis ,Humans ,Epidemics ,Gene ,Phylogeny ,Genetics ,Mutation ,Influenza A Virus, H3N2 Subtype ,Research ,Strain (biology) ,Genetic Drift ,virus diseases ,Sequence Analysis, DNA ,H3N2 ,Influenza ,respiratory tract diseases ,Infectious Diseases ,Southern china ,biology.protein ,RNA, Viral - Abstract
Background An influenza H3N2 epidemic occurred throughout Southern China in 2012. Methods We analyzed the hemagglutinin (HA) and neuraminidase (NA) genes of influenza H3N2 strains isolated between 2011–2012 from Guangdong. Mutation sites, evolutionary selection, antigenic sites, and N-glycosylation within these strains were analyzed. Results The 2011–2012 Guangdong strains contained the HA-A214S, HA-V239I, HA-N328S, NA-L81P, and NA-D93G mutations, similar to those seen in the A/ Perth/16/2009 influenza strain. The HA-NSS061–063 and NNS160–162 glycosylation sites were prevalent among the 2011–2012 Guangdong strains but the NA-NRS402–404 site was deleted. Antigenically, there was a four-fold difference between A/Perth/16/2009 -like strains and the 2011–2012 Guangdong strains. Conclusion Antigenic drift of the H3N2 subtype contributed to the occurrence of the Southern China influenza epidemic of 2012.
- Published
- 2013