1. Dengue virus envelope protein domain III-elicited antibodies mediate cross-protection against Zika virus in a mouse model
- Author
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Yongchao Zhou, Weiwei Zou, Yanjun Zhang, Dong Chen, Lan Yang, Jinsheng Wen, and Zhiliang Duan
- Subjects
Male ,Cancer Research ,Cross Protection ,viruses ,T cell ,Protein domain ,Dengue virus ,Biology ,Antibodies, Viral ,medicine.disease_cause ,Zika virus ,Mice ,Protein Domains ,Viral Envelope Proteins ,Antigen ,Neutralization Tests ,Virology ,Chlorocebus aethiops ,medicine ,Animals ,Vero Cells ,Gene ,Zika Virus Infection ,Immunization, Passive ,virus diseases ,Zika Virus ,Dengue Virus ,biochemical phenomena, metabolism, and nutrition ,biology.organism_classification ,Antibodies, Neutralizing ,In vitro ,Mice, Inbred C57BL ,Disease Models, Animal ,Infectious Diseases ,medicine.anatomical_structure ,Animals, Newborn ,biology.protein ,Female ,Immunization ,Antibody ,Immunity, Maternally-Acquired - Abstract
Dengue virus (DENV) and Zika virus (ZIKV) are antigenically related mosquito-transmitted viruses which represent a big public health problem. Although the antigenic cross-reactivity between two viruses were intensively investigated at the antibody and T cell levels, how DENV envelope protein domain III (EDIII)-elicited antibodies (Abs) impact the outcome of ZIKV infection is uncertain. Here, our results show that the sera isolated from DENV-EDIII-immunized wild-type mice recognized ZIKV-EDIII and cross-neutralized ZIKV in vitro. Passive transfer of DENV-EDIII-immune sera protected 1-day-old mice against lethal ZIKV challenge. Finally, maternally acquired anti-DENV-EDIII Abs significantly increased the survival of 1-day-old mice born to DENV-EDIII-immunized mothers post ZIKV challenge. These results reveal that DENV-EDIII-induced Abs provide cross-protection against ZIKV and may not mediate the Ab-dependent enhancement of ZIKV infection at the concentration used here. The present study would contribute to the development and application of DENV-EDIII-based vaccines.
- Published
- 2020