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Your search keyword '"Santos, Erika Ferreira dos"' showing total 3 results
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3 results on '"Santos, Erika Ferreira dos"'

1. Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population

Author

Rodrigues, Fabíola Brasil Barbosa, primary, da Silva, Rosilene, additional, Santos, Erika Ferreira dos, additional, de Brito, Mioni Thieli Figueiredo Magalhães, additional, da Silva, Andréa Luciana Soares, additional, de Meira Leite, Mauro, additional, Póvoa da Costa, Flávia, additional, de Nazaré do Socorro de Almeida Viana, Maria, additional, de Sarges, Kevin Matheus Lima, additional, Cantanhede, Marcos Henrique Damasceno, additional, Veríssimo, Adriana de Oliveira Lameira, additional, Carvalho, Mayara da Silva, additional, Henriques, Daniele Freitas, additional, Silva, Carla Pinheiro da, additional, Costa, Igor Brasil, additional, Nunes, Juliana Abreu Lima, additional, Costa, Iran Barros, additional, Viana, Giselle Maria Rachid, additional, Queiroz, Maria Alice Freitas, additional, Lima, Sandra Souza, additional, Lopes, Jeferson da Costa, additional, Torres, Maria Karoliny da Silva, additional, Vallinoto, Izaura Maria Vieira Cayres, additional, Bichara, Carlos David Araújo, additional, Vallinoto, Antonio Carlos Rosário, additional, and Santos, Eduardo José Melo dos, additional

Published
2023
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2. Antibody Response to the SARS-CoV-2 Spike and Nucleocapsid Proteins in Patients with Different COVID-19 Clinical Profiles

Author

Soares, Sinei Ramos, primary, da Silva Torres, Maria Karoliny, additional, Lima, Sandra Souza, additional, de Sarges, Kevin Matheus Lima, additional, Santos, Erika Ferreira dos, additional, de Brito, Mioni Thieli Figueiredo Magalhães, additional, da Silva, Andréa Luciana Soares, additional, de Meira Leite, Mauro, additional, da Costa, Flávia Póvoa, additional, Cantanhede, Marcos Henrique Damasceno, additional, da Silva, Rosilene, additional, de Oliveira Lameira Veríssimo, Adriana, additional, Vallinoto, Izaura Maria Vieira Cayres, additional, Feitosa, Rosimar Neris Martins, additional, Quaresma, Juarez Antônio Simões, additional, Chaves, Tânia do Socorro Souza, additional, Viana, Giselle Maria Rachid, additional, Falcão, Luiz Fábio Magno, additional, Santos, Eduardo José Melo dos, additional, Vallinoto, Antonio Carlos Rosário, additional, and da Silva, Andréa Nazaré Monteiro Rangel, additional

Published
2023
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3. Association of the IFNG +874T/A Polymorphism with Symptomatic COVID-19 Susceptibility.

Author

Sarges KML, Póvoa da Costa F, Santos EFD, Cantanhede MHD, da Silva R, Veríssimo AOL, Viana MNDSA, Rodrigues FBB, Leite MM, Torres MKDS, Bentes da Silva C, Brito MTFM, Silva ALSD, Henriques DF, Vallinoto IMVC, Viana GMR, Queiroz MAF, Vallinoto ACR, and Santos EJMD

Subjects
Female, Humans, Male, Alleles, Cytokine Release Syndrome genetics, Gene Frequency, Polymorphism, Single Nucleotide, Tumor Necrosis Factor-alpha genetics, COVID-19 genetics, COVID-19 virology, Genetic Predisposition to Disease, Genotype, Interferon-gamma genetics, SARS-CoV-2 pathogenicity
Abstract

Tumor necrosis factor (TNF) and interferon-gamma (IFNγ) are important inflammatory mediators in the development of cytokine storm syndrome (CSS). Single nucleotide polymorphisms (SNPs) regulate the expression of these cytokines, making host genetics a key factor in the prognosis of COVID-19. In this study, we investigated the associations of the TNF -308G/A and IFNG +874T/A polymorphisms with COVID-19. We analyzed the frequencies of the two polymorphisms in the control groups (CG: TNF -308G/A, n = 497; IFNG +874T/A, n = 397), a group of patients with COVID-19 (CoV, n = 222) and among the subgroups of patients with nonsevere ( n = 150) and severe ( n = 72) COVID-19. We found no significant difference between the genotypic and allelic frequencies of TNF -308G/A in the groups analyzed; however, both the frequencies of the high expression genotype (TT) (CoV: 13.51% vs. CG: 6.30%; p = 0.003) and the *T allele (CoV: 33.56% vs. CG: 24. 81%; p = 0.001) of the IFNG +874T/A polymorphism were higher in the COVID-19 group than in the control group, with no differences between the subgroups of patients with nonsevere and severe COVID-19. The *T allele of IFNG +874T/A (rs2430561) is associated with susceptibility to symptomatic COVID-19. These SNPs provided valuables clues about the potential mechanism involved in the susceptibility to developing symptomatic COVID-19.

Published
2024
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