Search

Showing total 1 results

Refine your results

1 results

1. Prolonged SARS-CoV-2 Infection in Patients Receiving Anti-CD20 Monoclonal Antibodies: A Diagnostic Challenged by Negative Nasopharyngeal RT-PCR and Successful Treatment with COVID-19 High-Titer Convalescent Plasma.

Author

Da Silva, Léa, Klopfenstein, Timothée, Gendrin, Vincent, Clouet, Julien, Toko, Lynda, Richier, Quentin, Leriche, Thomas, Nicolas, Raoul, Queijo, Alexis, Sreiri, Nour, Lacombe, Karine, and Zayet, Souheil

Subjects
*CONVALESCENT plasma, *COVID-19 treatment, *SARS-CoV-2, *TREATMENT effectiveness, *MONOCLONAL antibodies, *REVERSE transcriptase polymerase chain reaction
Abstract

We highlighted in this current paper similar prolonged respiratory presentation with COVID-19 pneumonia in four severely immunocompromised patients currently being treated with anti-CD20 monoclonal antibodies (mAbs), such as ocrelizumab and rituximab, for multiple sclerosis or rheumatoid polyarthritis. Real-time reverse transcription-polymerase chain reaction on a nasopharyngeal swab specimen was negative in all patients. SARS-CoV-2 infection was confirmed from bronchoalveolar lavage fluid. A high titer of post-vaccine COVID-19 convalescent plasma was administered with complete recovery in all patients. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF