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1. [Effect of alpha-tocopherol on the enzymatic activity of phospholipid biosynthesis and breakdown in burn injury].

Author

Mkhitarian VG, Agadzhanov MI, and Kazarian PA

Subjects
Animals, Brain metabolism, Burns metabolism, Enzyme Activation drug effects, Female, Lipid Peroxides metabolism, Liver metabolism, Rats, Time Factors, Burns drug therapy, Phospholipids metabolism, Vitamin E therapeutic use
Abstract

Burns affected the content of L-alpha-glycerophosphate /L-alpha-GP/ in rats; its level was reduced within 15 days after burns. Phasic changes in L-alpha-glycerophosphate dehydrogenase and glycerokinase activities in liver and brain tissues and phospholipase A in blood were also observed. Intraperitoneal administration of alpha-tocopheryl acetate into rats subjected to burns abolished the decrease in content of L-alpha-GP although the activity of the drug varied within this 15 day period. In brain the activity of these enzymes was increased 2-3-fold. The data obtained are in good agreement with those published previously and indicating loss of phospholipids in liver and brain tissus following burns.

Published
1979

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