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Inoculation to children of live measles L-16 vaccine was found to cause changes in the content of the main serum classes of immunoglobulins, A, M and G, and synthesis of specific antibody of various physico-chemical nature. Between these two values only a relative correlation was observed at 10--14 and 28--32 days after vaccination. Changes in the synthesis of serum immunoglobulins in the majority of the children were not great and statistically insignificant. Only in 2 children with hypergammaglobulinemia inoculation of measles L-16 vaccine induced intensive (statistically significant) increase in serum M and G globulins. The results indicate the necessity of further study of the effects of live measles vaccine on the immunological status of children which could probably reveal the causes of occurrence of unusual postvaccination reactions and complications.

The dynamics of the total content of measles antibody with reference to their physico-chemical nature and the dynamics of the content of the main classes of serum immunoglobulins (A, M, G) in children previously vaccinated and not vaccinated with live measles vaccine who developed measles were studied. Measles in the vaccines was found to run a course of the type of primary and secondary infection. In the former case, the normal dynamics of specific antibody was found with timely change of synthesis of antibody of various physico-chemical nature. In the latter case, immunity to measles developed according to the secondary type and was characterized by the absence of IgM measles antibody. The secondary immunological response was also characterized by higher antibody titers in the first days of the disease and decreased content of IgG and IgM in sera in the convalescent stage. Besides, in such children, hyperthermia occurred 3 times less frequently.