Search

Your search keyword '"Peter K Joshi"' showing total 3 results
Start Over Author "Peter K Joshi" Journal wellcome open research
3 results on '"Peter K Joshi"'

1. Variants associated with HHIP expression have sex-differential effects on lung function [version 2; peer review: 2 approved]

Author

Katherine A. Fawcett, Ma'en Obeidat, Carl Melbourne, Nick Shrine, Anna L. Guyatt, Catherine John, Jian'an Luan, Anne Richmond, Marta R. Moksnes, Raquel Granell, Stefan Weiss, Medea Imboden, Sebastian May-Wilson, Pirro Hysi, Thibaud S. Boutin, Laura Portas, Claudia Flexeder, Sarah E. Harris, Carol A. Wang, Leo-Pekka Lyytikäinen, Teemu Palviainen, Rachel E. Foong, Dirk Keidel, Cosetta Minelli, Claudia Langenberg, Yohan Bossé, Maarten Van den Berge, Don D. Sin, Ke Hao, Archie Campbell, David Porteous, Sandosh Padmanabhan, Blair H. Smith, David M. Evans, Sue Ring, Arnulf Langhammer, Kristian Hveem, Cristen Willer, Ralf Ewert, Beate Stubbe, Nicola Pirastu, Lucija Klaric, Peter K. Joshi, Karina Patasova, Mangino Massimo, Ozren Polasek, John M. Starr, Stefan Karrasch, Konstantin Strauch, Thomas Meitinger, Igor Rudan, Taina Rantanen, Kirsi Pietiläinen, Mika Kähönen, Olli T. Raitakari, Graham L. Hall, Peter D. Sly, Craig E. Pennell, Jaakko Kaprio, Terho Lehtimäki, Veronique Vitart, Ian J. Deary, Debbie Jarvis, James F. Wilson, Tim Spector, Nicole Probst-Hensch, Nicholas J. Wareham, Henry Völzke, John Henderson, David P. Strachan, Ben M. Brumpton, Caroline Hayward, Ian P. Hall, Martin D. Tobin, and Louise V. Wain

Subjects
Science, Medicine
Abstract

Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females. Methods: We tested for interactions between 7,745,864 variants and sex on spirometry-based measures of lung function in UK Biobank (N=303,612), and sought replication in 75,696 independent individuals from the SpiroMeta consortium. Results: Five independent single-nucleotide polymorphisms (SNPs) showed genome-wide significant (P

Published
2021

2. Variants associated with

Author

Katherine A, Fawcett, Ma'en, Obeidat, Carl, Melbourne, Nick, Shrine, Anna L, Guyatt, Catherine, John, Jian'an, Luan, Anne, Richmond, Marta R, Moksnes, Raquel, Granell, Stefan, Weiss, Medea, Imboden, Sebastian, May-Wilson, Pirro, Hysi, Thibaud S, Boutin, Laura, Portas, Claudia, Flexeder, Sarah E, Harris, Carol A, Wang, Leo-Pekka, Lyytikäinen, Teemu, Palviainen, Rachel E, Foong, Dirk, Keidel, Cosetta, Minelli, Claudia, Langenberg, Yohan, Bossé, Maarten, Van den Berge, Don D, Sin, Ke, Hao, Archie, Campbell, David, Porteous, Sandosh, Padmanabhan, Blair H, Smith, David M, Evans, Sue, Ring, Arnulf, Langhammer, Kristian, Hveem, Cristen, Willer, Ralf, Ewert, Beate, Stubbe, Nicola, Pirastu, Lucija, Klaric, Peter K, Joshi, Karina, Patasova, Mangino, Massimo, Ozren, Polasek, John M, Starr, Stefan, Karrasch, Konstantin, Strauch, Thomas, Meitinger, Igor, Rudan, Taina, Rantanen, Kirsi, Pietiläinen, Mika, Kähönen, Olli T, Raitakari, Graham L, Hall, Peter D, Sly, Craig E, Pennell, Jaakko, Kaprio, Terho, Lehtimäki, Veronique, Vitart, Ian J, Deary, Debbie, Jarvis, James F, Wilson, Tim, Spector, Nicole, Probst-Hensch, Nicholas J, Wareham, Henry, Völzke, John, Henderson, David P, Strachan, Ben M, Brumpton, Caroline, Hayward, Ian P, Hall, Martin D, Tobin, and Louise V, Wain

Subjects
genome-wide interaction study, HHIP, expression, sex, lung function, Articles, Research Article
Abstract

Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females. Methods: We tested for interactions between 7,745,864 variants and sex on spirometry-based measures of lung function in UK Biobank (N=303,612), and sought replication in 75,696 independent individuals from the SpiroMeta consortium. Results: Five independent single-nucleotide polymorphisms (SNPs) showed genome-wide significant (P

Published
2020

3. Variants associated with HHIP expression have sex-differential effects on lung function [version 1; peer review: 2 approved]

Author

Katherine A. Fawcett, Ma'en Obeidat, Carl Melbourne, Nick Shrine, Anna L. Guyatt, Catherine John, Jian'an Luan, Anne Richmond, Marta R. Moksnes, Raquel Granell, Stefan Weiss, Medea Imboden, Sebastian May-Wilson, Pirro Hysi, Thibaud S. Boutin, Laura Portas, Claudia Flexeder, Sarah E. Harris, Carol A. Wang, Leo-Pekka Lyytikäinen, Teemu Palviainen, Rachel E. Foong, Dirk Keidel, Cosetta Minelli, Claudia Langenberg, Yohan Bossé, Maarten Van den Berge, Don D. Sin, Ke Hao, Archie Campbell, David Porteous, Sandosh Padmanabhan, Blair H. Smith, David M. Evans, Sue Ring, Arnulf Langhammer, Kristian Hveem, Cristen Willer, Ralf Ewert, Beate Stubbe, Nicola Pirastu, Lucija Klaric, Peter K. Joshi, Karina Patasova, Mangino Massimo, Ozren Polasek, John M. Starr, Stefan Karrasch, Konstantin Strauch, Thomas Meitinger, Igor Rudan, Taina Rantanen, Kirsi Pietiläinen, Mika Kähönen, Olli T. Raitakari, Graham L. Hall, Peter D. Sly, Craig E. Pennell, Jaakko Kaprio, Terho Lehtimäki, Veronique Vitart, Ian J. Deary, Debbie Jarvis, James F. Wilson, Tim Spector, Nicole Probst-Hensch, Nicholas J. Wareham, Henry Völzke, John Henderson, David P. Strachan, Ben M. Brumpton, Caroline Hayward, Ian P. Hall, Martin D. Tobin, and Louise V. Wain

Subjects
Medicine, Science
Abstract

Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females. Methods: We tested for interactions between 7,745,864 variants and sex on spirometry-based measures of lung function in UK Biobank (N=303,612), and sought replication in 75,696 independent individuals from the SpiroMeta consortium. Results: Five independent single-nucleotide polymorphisms (SNPs) showed genome-wide significant (P

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results