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Background: In recent years, for the purpose of proper planning, the quality of life has been considered by researchers and clinical experts as one of the most important outcomes of chronic diseases. The aim of this study was to evaluate the quality of life and its dimensions in women and men with Human Immunodeficiency Virus (HIV) or Acquired Immunodeficiency Syndrome (AIDS) in the high-risk behaviors center of Shiraz. Methods: In this cross-sectional study, we selected 224 patients (112 man and 112 woman) with HIV / AIDS from Behavioral Counseling Center of Shiraz through convenience purposive sampling method; we gathered data using quality of life Short-Form 36 (SF36) and a demographic questionnaire. Data were analyzed using a t-test. Results: The mean score of general health (55.31±17.82) (P=0.367), physical health (287.85±81.16) (P=0.168), and psychological health of women (255.40±74.80) (P=0.207) was more than those with HIV/AIDS. The mean score of other quality of life dimensions in women was more than that of men; however, no significant differences were observed in other dimensions. Conclusion: The average score of quality of life in women was better than in men, hence the necessity of promoting calm adherence to treatment.