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2024 OCT 3 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Researchers detail new data in Nutritional and Metabolic Diseases and Conditions - Type 2 [...]

2024 OCT 3 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Data detailed on gestational diabetes have been presented. According to news reporting out of [...]

Researchers from Wuxi No.2 People's Hospital in China conducted a study on gestational diabetes, focusing on the potential biomarker miR-204-5p for diagnosing the condition and predicting poor maternal and infant outcomes. The study found that miR-204-5p expression was lower in gestational diabetes patients compared to healthy pregnant women, with a high diagnostic potential for distinguishing between the two groups. The researchers concluded that miR-204-5p could serve as a biomarker for the risk of gestational diabetes and its associated complications. [Extracted from the article]

A recent study conducted at Sorlandet Hospital HF focused on gestational diabetes and the use of glycated albumin (GA) in pregnancy. The research aimed to establish a reference interval for GA in gestational week 30 and assess its ability to detect gestational diabetes mellitus (GDM). The study concluded that GA alone cannot replace the oral glucose tolerance test (OGTT) for diagnosing GDM but combining GA with fasting glucose and BMI in early pregnancy could be a useful model to estimate the risk of GDM. The study was supported by the University of Agder and involved multiple researchers from Sorlandet Hospital HF in Norway. [Extracted from the article]

A recent study conducted at the University of Turku examined the incidence of gestational diabetes (GDM) and pregnancy outcomes in Kurdish, Somali, and general population women in Finland. The research found that Kurdish women had a higher incidence of GDM and less dietary treatment compared to the general population. Despite GDM status, Somali women had lower birth weights for their children. The study suggests that treatment for GDM should be tailored to better accommodate women from different cultural backgrounds. [Extracted from the article]

A recent study conducted at Hsinchu MacKay Memorial Hospital in Taiwan examined the risks associated with gestational diabetes mellitus (GDM) in primiparous women. The study found that women with GDM had a higher likelihood of emergency C-sections, infant health conditions, and postpartum complications compared to those without GDM. These adverse outcomes included fetal distress, malpresentation, pre-maturity, post-maturity, jaundice, perinatal infections, and postpartum complications such as perineum laceration and mastitis. The research concluded that GDM is linked to increased risks for both mothers and infants in this population. [Extracted from the article]

A recent study conducted at the University of South Dakota explored the impact of gestational diabetes on mitochondrial function and fatty acid uptake in human trophoblasts. The research found that exposure to high glucose and lipid conditions led to impaired mitochondrial function and decreased fatty acid uptake in trophoblasts, potentially increasing the risk of adverse outcomes for both placental and neonatal health. This study sheds light on how gestational diabetes affects the transport of essential fatty acids, highlighting the importance of understanding these mechanisms for maternal and fetal health. [Extracted from the article]

A recent study conducted by researchers at the University of Siena analyzed the correlation between socio-demographic variables and pathologies encountered by women during pregnancy, focusing on gestational diabetes, hypertension, and hospitalizations. The study found that the risk of gestational diabetes was significantly higher among mothers over 40 years old, with citizenship in certain countries, lower educational levels, and obesity. Additionally, the risk of gestational hypertension was higher among older mothers, obese mothers, and nulliparous mothers. The study concluded that early interventions and focusing on Early Childhood Development could improve children's health and well-being. [Extracted from the article]

A recent study conducted at Hainan Medical University in Haikou, People's Republic of China, focused on the impact of hemoglobin A1c (HbA1c), fasting blood glucose (FBG), 2-hours postprandial blood glucose (2hPBG), and fasting insulin (FINS) levels on pregnancy outcomes in patients with gestational diabetes mellitus (GDM). The research found that higher levels of these indicators were associated with adverse pregnancy outcomes in GDM patients. The study concluded that combined detection of these serum indicators could predict pregnancy outcomes in GDM patients more effectively than individual indicators alone. [Extracted from the article]

A recent study conducted by the Department of Biostatistics focused on the early prediction of gestational diabetes mellitus (GDM) using pregnancy-associated plasma protein-A (PAPP-A) in the first trimester of pregnancy. The research involved 344 pregnant women and found that PAPP-A showed promising accuracy in predicting GDM, with a sensitivity of 92% and specificity of 81%. The study concluded that PAPP-A could potentially be used as a screening tool for identifying GDM in the early stages of pregnancy. [Extracted from the article]

A recent study conducted by researchers at the University of Ruhuna in Sri Lanka focused on the utilization of gestational diabetes screening services among antenatal mothers in the region. The study found that there was a high utilization rate of screening tests, with coverage rates of 91.4% and 94.5% for the first and second screenings, respectively. Factors such as higher income, planned pregnancy, primiparity, and proximity to the nearest laboratory were associated with the utilization of screening services. The researchers concluded that while there was high utilization, efforts should be made to ensure timely screenings through improved availability and accessibility of screening facilities. [Extracted from the article]

A recent study from Newcastle University explores the effectiveness of psychoeducation interventions for pregnant women with gestational diabetes mellitus. The research highlights the high levels of stress and anxiety experienced by pregnant women diagnosed with gestational diabetes and emphasizes the importance of identifying interventions to help them cope. The study found that psychoeducational interventions focusing on informational and motivational support may enhance self-care behaviors, improve self-efficacy, and reduce stress and depression for women with gestational diabetes mellitus. Nurses and midwives are identified as key players in providing comprehensive care through these interventions. [Extracted from the article]

A study conducted by researchers from the Global Centre for Asian Women's Health found that breastfeeding is associated with lower rates of cardiovascular disease in women with type 2 diabetes or gestational diabetes. The study also revealed that a healthy Mediterranean diet with low exposure to persistent organic pollutants can lower the risk of gestational diabetes. The findings emphasize the importance of nutrition in managing the risks of non-communicable diseases and highlight the need for culturally sensitive dietary interventions for Asian women. The study aims to provide valuable insights to reduce the risk of cardio-metabolic disorders for women and their families, emphasizing the importance of international collaboration and dialogue in addressing diverse health challenges faced by women in Asia. [Extracted from the article]

A recent study conducted at Aarhus University focused on the care of pregnant women with diabetes in socially vulnerable positions, highlighting the complex medical, social, and psychological risks they face. The research emphasized the need for flexible and dynamic care that adjusts to the unique needs of these women, including monitoring insulin dosages, fetal weight, and coordinating social initiatives. The study concluded that care for these women is characterized by "if-then" scenarios, requiring continuous adaptation and adjustment to meet their diverse needs. For more information, the research article can be accessed in the European Journal of Public Health. [Extracted from the article]

A patent was issued for intelligent medication delivery systems and methods for medicine dose calculation and reporting by inventors Mensinger and Saint, assigned to Medtronic MiniMed Inc. The patent focuses on administering and tracking medicine for patients, providing health management capabilities for patients and caregivers. The system includes a smart insulin injection pen in wireless communication with a companion device, operating a software application that calculates and recommends medicine doses based on retrospective and predictive data. This innovation aims to enhance healthcare technology for women's health, particularly in managing conditions like gestational diabetes. [Extracted from the article]

The patent application titled "Systems And Methods For Assessing Sensor Surface Area Encapsulation In Vitro And In Vivo" discusses the development of a glucose sensor system to monitor glucose levels in users and adjust insulin injection accordingly. The system involves measuring electrode current signal values, generating Electrochemical Impedance Spectroscopy parameter values, estimating reaction surface area of the sensor, and adjusting calibration factors based on the comparison of estimated and expected reaction surface areas. This technology aims to improve the accuracy and efficiency of glucose monitoring for individuals with diabetes, including gestational diabetes during pregnancy. [Extracted from the article]

A study conducted at Sun Yat-sen University in Guangzhou, China, explored the association between diet quality during pregnancy and maternal glucose metabolism in Chinese women. The research found that excessive total food intake was linked to higher postprandial glucose levels, while lower compliance with dietary guidelines for animal food was associated with increased risk of gestational diabetes. The study highlights the importance of adhering to dietary guidelines during pregnancy to maintain healthy glucose levels. [Extracted from the article]

Researchers at the University of California Los Angeles (UCLA) have conducted a study on the risks of developing type 2 diabetes and cardiovascular diseases after gestational diabetes mellitus (GDM). The study found that individuals with GDM have an increased risk of developing type 2 diabetes, hypertension, and cardiovascular events compared to those without GDM. Racial and ethnic disparities exist in the progression from GDM to these health conditions, and further research is needed to inform tailored interventions for high-risk subpopulations. The study emphasizes the importance of early and frequent screening for diabetes and cardiovascular risks among individuals with GDM to prevent long-term health complications. [Extracted from the article]

A recent study conducted in Izmir, Turkey, explored the relationship between maternal plasma zonulin levels and gestational diabetes mellitus (GDM) and its perinatal outcomes. The research involved 100 pregnant women, with findings indicating that plasma zonulin levels were significantly higher in pregnant women with GDM in all trimesters. The study suggests that zonulin may serve as a potential marker for predicting GDM risk and perinatal outcomes, particularly in cases where women have an overweight body mass index (BMI). [Extracted from the article]

Researchers from Johns Hopkins University School of Medicine conducted a study on the association between ideal cardiovascular health (CVH) and history of gestational diabetes mellitus (GDM) in women. The study analyzed data from the National Health Examination and Nutrition Survey from 2007-2018 and found that women with higher ideal CVH scores had lower odds of past GDM history. The research highlights the importance of optimizing cardiometabolic health in women with a history of GDM. The study was supported by the American Heart Association and has been peer-reviewed. [Extracted from the article]

A recent qualitative study conducted by the Norwegian University of Science and Technology (NTNU) explored the experiences of postpartum follow-up and participation in a lifestyle intervention after gestational diabetes. The study involved in-depth interviews with 22 women in Norway who had gestational diabetes, focusing on factors that could improve intervention programs and postpartum support. The findings highlighted the importance of adequate information, individualized help, and support from others in motivating women to make and maintain healthy lifestyle changes. This research aims to inform the development of future intervention programs for women who have experienced gestational diabetes. [Extracted from the article]

Researchers from Duzce University conducted a case-control study on the role of incretins in gestational diabetes, focusing on the impact of obesity. The study included 96 pregnant women and found that impaired secretion of GLP-1, GLP-2, and GIP may contribute to the pathogenesis of gestational diabetes. GLP-1 was identified as a potential biomarker for diagnosing gestational diabetes. The findings suggest a potential link between incretins and gestational diabetes, particularly in obese individuals. [Extracted from the article]

A study conducted by Mazandaran University of Medical Sciences in Sari, Iran, aimed to evaluate the incidence of gestational diabetes mellitus and other pregnancy outcomes in women with abnormal fasting plasma glucose levels in the first trimester of pregnancy. The study found a significant relationship between impaired oral glucose tolerance tests and abnormal fasting plasma glucose levels, as well as associations with cesarean delivery type, insulin intake, and gestational age at delivery. The results suggest that fasting plasma glucose levels in the first trimester can serve as a simple and cost-effective screening test to identify pregnancies at risk of gestational diabetes and adverse pregnancy outcomes. [Extracted from the article]

A recent study conducted at Shahid Beheshti University of Medical Sciences in Tehran, Iran, compared the maternal and fetal outcomes of Iranian women with gestational diabetes treated with either metformin or insulin. The study found that both metformin and insulin were equally effective in controlling blood sugar levels and had comparable effects on maternal and neonatal outcomes. While there were some differences in outcomes between the two groups, such as slightly higher rates of respiratory distress in the metformin group and higher rates of preeclampsia in the insulin group, these differences were not statistically significant. The study concluded that metformin is a viable alternative to insulin for managing gestational diabetes in Iranian women. [Extracted from the article]

A study from the National Medical Research Center for Therapy and Preventive Medicine focuses on gender-specific characteristics of heart failure with preserved ejection fraction (HFpEF) in women, particularly related to pregnancy factors. The research highlights the association between pregnancy complications, such as hypertensive disorders and gestational diabetes mellitus, and the development of HFpEF in postmenopausal women. The study emphasizes the need for further investigation into these associations to identify new mechanisms for HFpEF development in women. [Extracted from the article]

A recent study conducted at Christian Medical College in Tamil Nadu, India, focused on the impact of obesity on pregnancy outcomes. The study found that overweight and obese pregnant women had increased odds of developing gestational diabetes mellitus and undergoing a cesarean section. Additionally, excess weight gain during pregnancy was associated with various complications, highlighting the importance of educating women on acceptable weight gain during pregnancy. The study underscores the need for healthcare providers to address weight management in pregnant women to improve maternal and neonatal health outcomes. [Extracted from the article]

A study conducted in India by the Gokhale Institute of Politics and Economics examined the prevalence of anemia, hypertension, and diabetes among pregnant women using data from the National Family Health Survey-4. The research found that 25.9% of pregnant women had anemia, while 4.4% had hypertension and 2.4% had diabetes. Socio-economic factors were identified as significant determinants of these conditions, with older women and those from lower wealth quintiles being at higher risk. The study emphasized the importance of early screening and tailored management strategies to reduce maternal and reproductive complications. [Extracted from the article]

The article discusses a study on markers of placental inflammation in pregnant women with gestational diabetes. The study focused on analyzing the levels of certain inflammatory markers in different compartments of pregnant women, including maternal serum, fetal serum, and amniotic membrane culture supernatant. The researchers found a higher production of IL-6 in the culture supernatant of the amniotic membrane of obese pregnant women and significantly more in pregnant women with gestational diabetes. The study did not observe a correlation between the levels of mediators detected in the three compartments. [Extracted from the article]

The article discusses the EAGER pilot trial, which aims to assess the feasibility of inducing labor at 38 weeks compared to expectant management for individuals with gestational diabetes mellitus (GDM). The trial will recruit 260 participants from Canadian sites and evaluate perinatal outcomes. The study will collect baseline data, assess glycemic control, and follow participants through delivery and postpartum. Findings from this pilot will inform the design of a future full-scale randomized controlled trial. [Extracted from the article]

A recent study conducted at Charite University Hospital and School of Medicine in Berlin, Germany, explored the predictive value of estradiol (E2) related parameters on the incidence of gestational diabetes mellitus (GDM) in women undergoing fresh embryo transfer. The study identified an optimal E2/follicle (E2/F) ratio threshold of 246.03 pg/ml on the day of human chorionic gonadotropin (hCG) administration, which was associated with lower rates of GDM and ovarian hyperstimulation syndrome (OHSS). The research concluded that an E2/F ratio over 246.03 pg/ml is significantly linked to a reduced risk of both GDM and OHSS, making it a superior predictive biomarker compared to other E2-related parameters. [Extracted from the article]

Researchers from the Medical College of Wisconsin have highlighted the increasing incidence of gestational diabetes mellitus (GDM) in the United States and globally. While diet and exercise are the first-line treatments for GDM, approximately 30% of patients may require pharmacotherapy. The study aims to summarize recent and ongoing trials focusing on GDM pharmacotherapy, addressing controversies surrounding glycemic threshold values and treatment intensity. This research, supported by the U.S. Department of Health and Human Services, National Institutes of Health, emphasizes the need for further exploration of pharmacological treatments for gestational diabetes. [Extracted from the article]

Researchers from Virgen de la Victoria University Hospital conducted a study on gestational diabetes, focusing on the impact of insulin treatment on DNA methylation in genes related to vitamin D metabolism. The study involved 32 pregnant women, half of whom had gestational diabetes and were divided into insulin-treated and lifestyle groups. The findings suggested that insulin treatment in gestational diabetes could influence DNA methylation in genes involved in vitamin D metabolism, affecting vitamin D levels during and after pregnancy. Further research is needed to explore the clinical implications of these findings. [Extracted from the article]

A recent study conducted at the University of California explored the association between microbiome-derived metabolites in early to mid-pregnancy and the risk of gestational diabetes (GDM). The research involved a diverse population and found that certain microbiome-derived metabolites were positively associated with GDM risk. The study concluded that dysbiosis in microbiome-derived metabolites is present early in pregnancy among individuals progressing to GDM. More information on this research can be found in the BMC Medicine journal article. [Extracted from the article]

Researchers from Fujian Medical University conducted a study to explore the risk factors for low-birth-weight infants born to pregnant women with gestational diabetes mellitus (GDM). The study included 386 diabetic mothers and infants, with statistically significant factors such as maternal age over 36 years, junior high school education, and gestational hypertension. The researchers developed a prediction model and nomogram to help identify the risk of low birth weight in newborns, aiming to improve personalized treatment for pregnant women with GDM and enhance infant outcomes. [Extracted from the article]

A recent cohort study conducted at the University of Southern Santa Catarina in Brazil examined the impact of gestational diabetes mellitus (GDM) on pregnancy outcomes for women and their offspring. The study found that pregnant women with GDM had a higher risk of complications during childbirth and cesarean birth compared to those without GDM. Additionally, newborns born to mothers with GDM had a higher risk of being large for gestational age, having low Apgar scores, and experiencing birth asphyxia. The research highlights the importance of managing GDM to prevent adverse outcomes for both mothers and babies. [Extracted from the article]

A recent study conducted by Nanjing Medical University focused on the fluctuation trend of inflammatory indexes related to gestational diabetes mellitus (GDM) from the second trimester to the third trimester of pregnancy. The study involved 65 pregnant women diagnosed with GDM and 65 pregnant women without GDM. Results showed significant changes in the levels of NLRP3, IL-1Ra, and TBP-2 in GDM patients, with NLRP3 identified as an independent factor influencing GDM. The study concluded that these inflammatory indexes play a crucial role in predicting the occurrence of GDM and the weight of newborns. [Extracted from the article]

A study conducted at Tianjin Medical University in China analyzed the association between serum concentrations of per- and polyfluoroalkyl substances (PFASs) in early pregnancy and the risk of gestational diabetes mellitus (GDM) among pregnant women. The research found that exposure to PFAS in early pregnancy is linked to the occurrence of GDM, with PFNA, PFOA, and PFPeS identified as risk factors for GDM. This study provides insights for the prevention and control of GDM and the development of related environmental health policies. [Extracted from the article]

Researchers at the University of Santo Tomas conducted a study on gestational diabetes, aiming to identify potential early biomarkers for the condition among Filipino pregnant women. The study analyzed gene expressions of Protein Tyrosine Phosphatase Receptor-type Gamma (PTPRG) and Immunoglobulin Kappa Variable 2D-28 (IGKV2D-28) in first-trimester blood samples from GDM and non-GDM patients. The findings showed elevated expression levels of PTPRG and IGKV2D-28 in the GDM cohort, with PTPRG exhibiting a sensitivity of 83% and IGKV2D-28 demonstrating a specificity of 94%. Further validation studies are needed to confirm these results and explore additional biomarkers for improved diagnostic precision in GDM pregnancies. [Extracted from the article]

A study conducted by the Department of Obstetrics and Gynecology explored the association between body mass index (BMI) and perinatal outcomes of women delivering at advanced maternal age (AMA). The research included 261 Chinese women aged 35 and above who delivered at Shanghai Putuo Maternity and Infant Health Hospital. The study found that overweight women had a higher risk of gestational diabetes mellitus (GDM) and cesarean section (CS) compared to women in the normal BMI group. Effective weight management during pregnancy may help reduce adverse perinatal complications in AMA women. [Extracted from the article]