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Asparagus africanusLam. (Asparagaceae) is a widely used plant in traditional medicine as an anti-inflammatory, antioxidant, for the treatment of nervous disorders and epilepsy. The objective of this work was to study the anticonvulsant effects ofA. africanusroot decoction in white mice (Mus musculusSwiss) induced by pilocarpine. The experimental induction of "status epilepticus" and the evaluation of the anticonvulsant effects ofA. africanusroot decoction on pilocarpine-induced clonic and tonic convulsions were carried out. Seizure severity, latency, duration and number of clonics and tonics convulsions were evaluated. Concentrations of GABA, GABA-T, TNF-α and stress markers in the brains of mice were also estimated.A. africanusdecreased the duration and number of clonic and tonic convulsions which increased the latency time of onset of clonic and tonic convulsions significantly and in a dose-dependent manner. GABA increased significantly in the brains of animals treated withA. africanusand a significant decrease of GABA-T and TNF-α.A. africanusalso showed antioxidant effects. These results show thatA. africanushas anticonvulsant effects.A. africanuswould thus contain beneficial antiradical constituents in the treatment of epilepsy. These constituents would thus oppose free radicals. These results would justify the use of this plant in traditional medicine in the treatment of epilepsy.