1. Choledochal cysts: Similarities and differences between Asian and Western countries.
- Author
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Baison GN, Bonds MM, Helton WS, and Kozarek RA
- Subjects
- Asian People statistics & numerical data, Biliary Tract Neoplasms pathology, Choledochal Cyst pathology, Choledochal Cyst surgery, Female, Gastroenterology standards, Humans, Male, Practice Guidelines as Topic, Prevalence, Sex Factors, Treatment Outcome, White People statistics & numerical data, Biliary Tract Neoplasms prevention & control, Cholangiopancreatography, Endoscopic Retrograde standards, Choledochal Cyst epidemiology
- Abstract
Choledochal cysts (CCs) are rare bile duct dilatations, intra-and/or extrahepatic, and have higher prevalence in the Asian population compared to Western populations. Most of the current literature on CC disease originates from Asia where these entities are most prevalent. They are thought to arise from an anomalous pancreaticobiliary junction, which are congenital anomalies between pancreatic and bile ducts. Some similarities in presentation between Eastern and Western patients exist such as female predominance, however, contemporary studies suggest that Asian patients may be more symptomatic on presentation. Even though CC disease presents with an increased malignant risk reported to be more than 10% after the second decade of life in Asian patients, this risk may be overstated in Western populations. Despite this difference in cancer risk, management guidelines for all patients with CC are based predominantly on observations reported from Asia where it is recommended that all CCs should be excised out of concern for the presence or development of biliary tract cancer., Competing Interests: Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors who contributed their efforts in this manuscript. more...
- Published
- 2019
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