4 results on '"Michela Visani"'
Search Results
2. Molecular alterations in pancreatic tumors
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Annalisa Pession, Lidia Merlo, Antonio De Leo, Dario de Biase, Enrico Franceschi, Giorgia Acquaviva, Michele Masetti, Monica Di Battista, Sirio Fiorino, Viviana Sanza, Alba A. Brandes, Giovanni Tallini, Elio Jovine, Michela Visani, Thais Maloberti, Visani M., Acquaviva G., de Leo A., Sanza V., Merlo L., Maloberti T., Brandes A.A., Franceschi E., Di Battista M., Masetti M., Jovine E., Fiorino S., Pession A., Tallini G., and de Biase D.
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Molecular alteration ,DNA damage ,Review ,Molecular marker ,Biology ,Pancreatic ductal adenocarcinomas ,medicine.disease_cause ,law.invention ,Pancreatic ductal adenocarcinoma ,03 medical and health sciences ,Pancreatic tumor ,0302 clinical medicine ,law ,Genome maintenance ,medicine ,Humans ,Molecular alterations ,Pancreatic carcinoma ,Pancreatic lesion ,Endoscopic Ultrasound-Guided Fine Needle Aspiration ,Gene ,Oncogene ,Mutation ,Pancreatic tumors ,Intraductal papillary mucinous neoplasm ,Gastroenterology ,Molecular markers ,Oncogenes ,General Medicine ,medicine.disease ,Pancreatic Neoplasms ,030220 oncology & carcinogenesis ,Cancer research ,Suppressor ,030211 gastroenterology & hepatology ,Mutations ,Human ,Carcinoma, Pancreatic Ductal - Abstract
Genetic alterations in pancreatic tumors can usually be classified in: (1) Mutational activation of oncogenes; (2) Inactivation of tumor suppressor genes; and (3) Inactivation of genome maintenance genes controlling the repair of DNA damage. Endoscopic ultrasound-guided fine-needle aspiration has improved pre-operative diagnosis, but the management of patients with a pancreatic lesion is still challenging. Molecular testing could help mainly in solving these “inconclusive” specimens. The introduction of multi-gene analysis approaches, such as next-generation sequencing, has provided a lot of useful information on the molecular characterization of pancreatic tumors. Different types of pancreatic tumors (e.g., pancreatic ductal adenocarcinomas, intraductal papillary mucinous neoplasms, solid pseudopapillary tumors) are characterized by specific molecular alterations. The aim of this review is to summarize the main molecular alterations found in pancreatic tumors.
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- 2021
3. Possible association between hepatitis C virus and malignancies different from hepatocellular carcinoma: A systematic review
- Author
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Carlo Fabbri, Giorgia Acquaviva, Raffaele Lombardi, Laura Pontoriero, Fabio Grizzi, Andrea Cuppini, Elio Jovine, Luca Di Tommaso, Arrigo Bondi, Sergio Sabbatani, Michele Masetti, Michela Visani, Andrea Tura, Adele Fornelli, Annalisa Pession, Laura Mastrangelo, Matteo Zanello, Sirio Fiorino, Letizia Bacchi-Reggiani, Dario de Biase, Fiorino, Sirio, Bacchi Reggiani, Maria Letizia, De Biase, Dario, Fornelli, Adele, Masetti, Michele, Tura, Andrea, Grizzi, Fabio, Zanello, Matteo, Mastrangelo, Laura, Lombardi, Raffaele, Acquaviva, Giorgia, Di Tommaso, Luca, Bondi, Arrigo, Visani, Michela, Sabbatani, Sergio, Pontoriero, Laura, Fabbri, Carlo, Cuppini, Andrea, Pession, Annalisa, and Jovine, Elio
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Oncology ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Systematic Reviews ,Hepatocellular carcinoma ,Hepatitis C virus ,macromolecular substances ,Hepacivirus ,medicine.disease_cause ,Risk Assessment ,Cholangiocarcinoma ,Breast cancer ,Risk Factors ,Internal medicine ,Pancreatic cancer ,Neoplasms ,Medicine ,Humans ,Thyroid cancer ,Cancer ,business.industry ,Liver Neoplasms ,Gastroenterology ,virus diseases ,General Medicine ,Hepatitis C ,Extra-hepatic malignancie ,medicine.disease ,digestive system diseases ,Neoplasm ,Risk factor ,business ,Hepatitis C viru ,Kidney cancer - Abstract
AIM: To summarize the current knowledge about the potential relationship between hepatitis C virus (HCV) infection and the risk of several extra-liver cancers. METHODS: We performed a systematic review of the literature, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) Statement. We extracted the pertinent articles, published in MEDLINE and the Cochrane Library, using the following search terms: neoplasm/cancer/malignancy/tumor/carcinoma/adeno-carcinoma and non-Hodgkin lymphomas, kidney/renal-, cholangio-, pancreatic-, thyroid-, breast-,oral-, skin-, prostate-, lung-, colon-, stomach-, haematologic. Case series, case-series with control-group, case-control, cohort-studies as well as meta-analyses, written in English were collected. Some of the main characteristics of retrieved trials, which were designed to investigate the prevalence of HCV infection in each type of the above-mentioned human malignancies were summarised. A main table was defined and included a short description in the text for each of these tumours, whether at least five studies about a specific neoplasm, meeting inclusion criteria, were available in literature. According to these criteria, we created the following sections and the corresponding tables and we indicated the number of included or excluded articles, as well as of meta-analyses and reviews: (1) HCV and haematopoietic malignancies; (2) HCV and cholangiocarcinoma; (3) HCV and pancreatic cancer; (4) HCV and breast cancer; (5) HCV and kidney cancer; (6) HCV and skin or oral cancer; and (7) HCV and thyroid cancer. RESULTS: According to available data, a clear correlation between regions of HCV prevalence and risk of extra-liver cancers has emerged only for a very small group of types and histological subtypes of malignancies. In particular, HCV infection has been associated with: (1) a higher incidence of some B-cell Non-Hodgkin-Lymphoma types, in countries, where an elevated prevalence of this pathogen is detectable, accounting to a percentage of about 10%; (2) an increased risk of intra-hepatic cholangiocarcinoma; and (3) a correlation between HCV prevalence and pancreatic cancer (PAC) incidence. CONCLUSION: To date no definitive conclusions may be obtained from the analysis of relationship between HCV and extra-hepatic cancers. Further studies, recruiting an adequate number of patients are required to confirm or deny this association.
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- 2015
4. MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis B- and C-related-hepatocellular-carcinoma
- Author
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Laura Mastrangelo, Dario de Biase, Sirio Fiorino, Andrea Domanico, Michela Visani, Andrea Tura, Arrigo Bondi, Adele Fornelli, Giorgia Acquaviva, Luca Di Tommaso, Carlo Fabbri, Michele Masetti, Raffaele Lombardi, Paolo Leandri, Sergio Sabbatani, Matteo Zanello, Maria Letizia Bacchi-Reggiani, Elio Jovine, Fabio Grizzi, Annalisa Pession, Fiorino, Sirio, BACCHI REGGIANI, MARIA LETIZIA, Visani, Michela, Acquaviva, Giorgia, Fornelli, Adele, Masetti, Michele, Tura, Andrea, Grizzi, Fabio, Zanello, Matteo, Mastrangelo, Laura, Lombardi, Raffaele, DI TOMMASO, LUCA LUIGI, Bondi, Arrigo, Sabbatani, Sergio, Domanico, Andrea, Fabbri, Carlo, Leandri, Paolo, Pession, Annalisa, Jovine, Elio, and DE BIASE, Dario
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0301 basic medicine ,Oncology ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Hepatocellular carcinoma ,Prognosi ,Molecular Diagnostic Technique ,Hepatitis C virus ,Predictive Value of Test ,Review ,medicine.disease_cause ,03 medical and health sciences ,Predictive Value of Tests ,Internal medicine ,microRNA ,Biomarkers, Tumor ,medicine ,Humans ,Topic Highlight ,Early Detection of Cancer ,Hepatitis B virus ,business.industry ,Liver Neoplasms ,Gastroenterology ,MicroRNA ,Hepatitis B viru ,General Medicine ,Hepatitis C ,Hepatitis B ,Prognosis ,medicine.disease ,digestive system diseases ,MicroRNAs ,030104 developmental biology ,Systematic review ,Molecular Diagnostic Techniques ,Liver Neoplasm ,Predictive value of tests ,Hepatitis C viru ,business ,Liver disease ,Human - Abstract
Aim of the present review is to summarize the current knowledge about the potential relationship between miRNAs and hepatitis B virus (HBV)-hepatitis C virus (HCV) related liver diseases. A systematic computer-based search of published articles, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis Statement, was performed to identify relevant studies on usefulness of serum/plasma/urine miRNAs, as noninvasive biomarkers for early detection of HBV and HCV-induced hepatocellular carcinoma (HCC) development, as well as for its prognostic evaluation. The used Medical Subject Headings terms and keywords were: “HBV”, “HCV”, “hepatocellular carcinoma”, “microRNAs”, “miRNAs”, “diagnosis”, “prognosis”, “therapy”, “treatment”. Some serum/plasma miRNAs, including miR-21, miR-122, mi-125a/b, miR-199a/b, miR-221, miR-222, miR-223, miR-224 might serve as biomarkers for early diagnosis/prognosis of HCC, but, to date, not definitive results or well-defined panels of miRNAs have been obtained. More well-designed studies, focusing on populations of different geographical areas and involving larger series of patients, should be carried out to improve our knowledge on the potential role of miRNAs for HCC early detection and prognosis.
- Published
- 2016
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