18 results on '"Mu, Xin"'
Search Results
2. Effects of early enteral nutrition on Th17/Treg cells and IL-23/IL-17 in septic patients
- Author
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Sun, Jia-Kui, primary, Zhang, Wen-Hao, additional, Chen, Wen-Xiu, additional, Wang, Xiang, additional, and Mu, Xin-Wei, additional
- Published
- 2019
- Full Text
- View/download PDF
3. Histological changes of gastric mucosa after Helicobacter pylori eradication: a systematic review and meta-analysis
- Author
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Hong-Gang Yi, Mu-Xin Wei, Yan-Jun Kong, and Jun-Cheng Dai
- Subjects
Gastritis, Atrophic ,medicine.medical_specialty ,Stomach Diseases ,macromolecular substances ,Comorbidity ,Gastroenterology ,Helicobacter Infections ,Internal medicine ,Gastric mucosa ,Medicine ,Humans ,Antrum ,Metaplasia ,biology ,Helicobacter pylori ,business.industry ,Stomach ,digestive, oral, and skin physiology ,Intestinal metaplasia ,General Medicine ,Publication bias ,biology.organism_classification ,Random effects model ,medicine.disease ,bacterial infections and mycoses ,digestive system diseases ,Anti-Bacterial Agents ,Intestinal Diseases ,medicine.anatomical_structure ,Gastric Mucosa ,Meta-analysis ,Disease Progression ,sense organs ,business ,Meta-Analysis - Abstract
AIM: To systematically review pathological changes of gastric mucosa in gastric atrophy (GA) and intestinal metaplasia (IM) after Helicobacter pylori (H. pylori) eradication. METHODS: A systematic search was made of PubMed, Web of Science, EMBASE, ClinicalTrials.gov, OVID and the Cochran Library databases for articles published before March 2013 pertaining to H. pylori and gastric premalignant lesions. Relevant outcomes from articles included in the meta-analysis were combined using Review Manager 5.2 software. A Begg’s test was applied to test for publication bias using STATA 11 software. χ2 and I2 analyses were used to assess heterogeneity. Analysis of data with no heterogeneity (P > 0.1, I2 < 25%) was carried out with a fixed effects model, otherwise the causes of heterogeneity were first analyzed and then a random effects model was applied. RESULTS: The results of the meta-analysis showed that the pooled weighted mean difference (WMD) with 95%CI was 0.23 (0.18-0.29) between eradication and non-eradication of H. pylori infection in antral IM with a significant overall effect (Z = 8.19; P
- Published
- 2013
4. Effects of Chinese herbs on salivary fluid secretion by isolated and perfused rat submandibular glands
- Author
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Qian-De Zhang, Wei Ding, Masataka Murakami, and Mu-Xin Wei
- Subjects
medicine.medical_specialty ,Saliva ,Carbachol ,Submandibular Gland ,Saliva secretion ,Stimulation ,Cholinergic Agonists ,complex mixtures ,Xerostomia ,stomatognathic system ,Internal medicine ,medicine ,Animals ,Secretion ,Medicine, Chinese Traditional ,Rats, Wistar ,skin and connective tissue diseases ,Salivary gland ,integumentary system ,business.industry ,Gastroenterology ,General Medicine ,Submandibular gland ,Rats ,Brief Articles ,stomatognathic diseases ,Endocrinology ,medicine.anatomical_structure ,business ,Perfusion ,medicine.drug ,Drugs, Chinese Herbal - Abstract
AIM: To determine whether Chinese herbs (CHs) relieve xerostomia (dry mouth) by increasing salivary secretion. METHODS: The submandibular glands of Wistar rats were surgically isolated and perfused arterially with buffered salt solution. After control perfusion, recording started 5 min prior to the start of stimulation. After fluid secretion was induced by 0.2 μmol/L carbamylcholine (CCh) in the perfusate for 10 min, Chinese herb (CH) was added in the perfusion for 5 min. CCh was then overloaded at 0.2 μmol/L in the perfusion for 20 min. The volume of salivary fluid secretion was recorded by a computer-controlled balance system. RESULTS: Saliva secretion formed an initial ephemeral peak at 30 s followed by a gradual increase to a sustained level. CH alone induced no or little saliva in all types of CH selected. During perfusion with CH, overloading of CCh promoted fluid secretion in 15 of 20 CHs. This promotion was classified into four patterns, which were eventually related to the categories of CH: Overall sustained phase was continuously raised (Yin-nourishing, fluid production-promoting and heat-clearing agents); The sustained secretion rose to reach a maximum then decreased (Qi-enhancing agent); Sustained secretion rose to reach the highest maximum and was then sustained with a slight decline (swelling-reducing, phlegm-resolving and pus-expelling agents); Stimulation of salivary secretion without any added stimulants. Addition of CCh raised the fluid secretion to reach the highest maximum then sharply decreased to a lower sustained level (blood activating agent). CONCLUSION: The present findings lead to the conclusion that various CHs have different promotional effects directly on the salivary gland.
- Published
- 2009
5. Mechanism involved in Danshen-induced fluid secretion in salivary glands
- Author
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Mu-Xin Wei, Fei Wei, and Masataka Murakami
- Subjects
Male ,medicine.medical_specialty ,Saliva ,Time Factors ,Submandibular Gland ,Salvia miltiorrhiza ,Stimulation ,Plant Roots ,Ouabain ,Oxygen Consumption ,Phentolamine ,stomatognathic system ,Internal medicine ,Muscarinic acetylcholine receptor ,otorhinolaryngologic diseases ,medicine ,Animals ,Solute Carrier Family 12, Member 2 ,Rats, Wistar ,Plants, Medicinal ,Dose-Response Relationship, Drug ,Chemistry ,Gastroenterology ,Muscarinic acetylcholine receptor M3 ,General Medicine ,Basic Study ,Submandibular gland ,stomatognathic diseases ,Endocrinology ,medicine.anatomical_structure ,Calcium ,Sodium-Potassium-Exchanging ATPase ,Salivation ,Bumetanide ,Drugs, Chinese Herbal ,Phytotherapy ,Signal Transduction ,medicine.drug - Abstract
AIM: Danshen’s capability to induce salivary fluid secretion and its mechanisms were studied to determine if it could improve xerostomia. METHODS: Submandibular glands were isolated from male Wistar rats under systemic anesthesia with pentobarbital sodium. The artery was cannulated and vascularly perfused at a constant rate. The excretory duct was also cannulated and the secreted saliva was weighed in a cup on an electronic balance. The weight of the accumulated saliva was measured every 3 s and the salivary flow rate was calculated. In addition, the arterio-venous difference in the partial oxygen pressure was measured as an indicator of oxygen consumption. In order to assess the mechanism involved in Danshen-induced fluid secretion, either ouabain (an inhibitor of Na+/K+ ATPase) or bumetanide (an inhibitor of NKCC1) was additionally applied during the Danshen stimulation. In order to examine the involvement of the main membrane receptors, atropine was added to block the M3 muscarinic receptors, or phentolamine was added to block the α1 adrenergic receptors. In order to examine the requirement for extracellular Ca2+, Danshen was applied during the perfusion with nominal Ca2+ free solution. RESULTS: Although Danshen induced salivary fluid secretion, 88.7 ± 12.8 μL/g-min, n = 9, (the highest value around 20 min from start of DS perfusion was significantly high vs 32.5 ± 5.3 μL/g-min by carbamylcholine, P = 0.00093 by t-test) in the submandibular glands, the time course of that secretion differed from that induced by carbamylcholine. There was a latency associated with the fluid secretion induced by Danshen, followed by a gradual increase in the secretion to its highest value, which was in turn followed by a slow decline to a near zero level. The application of either ouabain or bumetanide inhibited the fluid secretion by 85% or 93%, and suppressed the oxygen consumption by 49% or 66%, respectively. These results indicated that Danshen activates Na+/K+ ATPase and NKCC1 to maintain Cl- release and K+ release for fluid secretion. Neither atropine or phentolamine inhibited the fluid secretion induced by Danshen (263% ± 63% vs 309% ± 45%, 227% ± 63% vs 309% ± 45%, P = 0.899, 0.626 > 0.05 respectively, by ANOVA). Accordingly, Danshen does not bind with M3 or α1 receptors. These characteristics suggested that the mechanism involved in DS-induced salivary fluid secretion could be different from that induced by carbamylcholine. Carbamylcholine activates the M3 receptor to release inositol trisphosphate (IP3) and quickly releases Ca2+ from the calcium stores. The elevation of [Ca2+]i induces chloride release and quick osmosis, resulting in an onset of fluid secretion. An increase in [Ca2+]i is essential for the activation of the luminal Cl- and basolateral K+ channels. The nominal removal of extracellular Ca2+ totally abolished the fluid secretion induced by Danshen (1.8 ± 0.8 μL/g-min vs 101.9 ± 17.2 μL/g-min, P = 0.00023 < 0.01, by t-test), suggesting the involvement of Ca2+ in the activation of these channels. Therefore, IP3-store Ca2+ release signalling may not be involved in the secretion induced by Danshen, but rather, there may be a distinct signalling process. CONCLUSION: The present findings suggest that Danshen can be used in the treatment of xerostomia, to avoid the systemic side effects associated with muscarinic drugs.
- Published
- 2015
6. Possible key residues that determine left gastric artery blood flow response to PACAP in dogs
- Author
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Wei, Mu-Xin, primary
- Published
- 2010
- Full Text
- View/download PDF
7. Effects of Chinese herbs on salivary fluid secretion by isolated and perfused rat submandibular glands
- Author
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Murakami, Masataka, primary, Wei, Mu-Xin, additional, Ding, Wei, additional, and Zhang, Qian-De, additional
- Published
- 2009
- Full Text
- View/download PDF
8. Possible key residues that determine left gastric artery blood flow response to PACAP in dogs
- Author
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Kiyoshi Nokihara, Ping Hu, Ping Wang, Victor Wray, Satoru Naruse, Mu-Xin Wei, and Tsuyoshi Ozaki
- Subjects
medicine.medical_specialty ,Brief Article ,Left gastric artery ,Molecular Sequence Data ,Vasoactive intestinal peptide ,Adenylate kinase ,Hemodynamics ,Dogs ,Internal medicine ,medicine.artery ,Animals ,Medicine ,Amino Acid Sequence ,Receptor ,business.industry ,Stomach ,Gastroenterology ,Arteries ,General Medicine ,Blood flow ,Endocrinology ,medicine.anatomical_structure ,Regional Blood Flow ,Pituitary Adenylate Cyclase-Activating Polypeptide ,Peptides ,business ,Vasoactive Intestinal Peptide - Abstract
To determine the effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on left gastric artery (LGA) flow and to unveil the structural or functional important sites that may be critical for discrimination of different receptor subtypes.Peptides, including PACAP-27, PACAP-38, amino acid substituted PACAP-27 and C-terminus truncated analogues PACAP (27-38), were synthesized by a simultaneous multiple solid-phase peptide synthesizer. Flow probes of an ultrasound transit-time blood flowmeter were placed around the LGA of beagle dogs. When peptides were infused intravenously, the blood flow was measured.[Ala4, Val5]-PACAP-27 caused a concentration-dependent vasodepressor action which was similar to that caused by PACAP-27. The LGA blood flow response to [Ala4, Val5]-PACAP-27 was significantly higher than that to PACAP-27, which was similar to that to vasoactive intestinal polypeptide (VIP) at the same dose. [Ala6]-PACAP-27 did not increase the peak LGA flow. [Gly8]-PACAP-27 showed a similar activity to VIP. [Asn24, Ser25, Ile26]-PACAP-27 did not change the activity of peptides at all doses.NH2 terminus is more important to biological activity of peptides and specific receptor recognition than COOH-terminus.
- Published
- 2010
9. Comparative analysis of common CFTR polymorphisms poly-T, TG-repeats and M470V in a healthy Chinese population
- Author
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Huang, Qin, primary, Ding, Wei, additional, and Wei, Mu-Xin, additional
- Published
- 2008
- Full Text
- View/download PDF
10. Comparative analysis of common CFTR polymorphisms poly-T, TG-repeats and M470V in a healthy Chinese population
- Author
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Mu-Xin Wei, Qin Huang, and Wei Ding
- Subjects
Adult ,Male ,congenital, hereditary, and neonatal diseases and abnormalities ,China ,Adolescent ,DNA Mutational Analysis ,Cystic Fibrosis Transmembrane Conductance Regulator ,Biology ,White People ,Random Allocation ,Asian People ,Gene Frequency ,Humans ,Alleles ,Aged ,Aged, 80 and over ,Genetics ,Chinese population ,Polymorphism, Genetic ,Incidence (epidemiology) ,Haplotype ,Gastroenterology ,General Medicine ,Middle Aged ,Haplotypes ,Female ,Rapid Communication - Abstract
To investigate the three important cystic fibrosis transmembrane conductance regulator (CFTR) haplotypes poly-T, TG-repeats and the M470V polymorphisms in the Chinese population, and to compare their distribution with that in Caucasians and other Asian populations.Genomic DNA was extracted from blood leukocytes. Exons 9 and 10 of the CFTR gene were obtained through polymerase chain reaction (PCR). Exon 9 DNA sequences were directly detected by an automated sequencer and poly-T and TG-repeats were identified by direct sequence analysis. Pure exon 10 PCR-amplified products were digested by HphI restriction enzyme and the M470V mutation was detected by the AGE photos of digestion products.T7 was the most common (93.6%) haplotype and the (TG)11 frequency of 57.2% and (TG)12 frequency of 40.9% were dominant haplotypes in the junction of intron 8 (IVS-8) and exon 9. The frequency of T5 was 3.8% and all T5 allele tracts (10 alleles) were joined with (TG)12. Four new alleles of T6 (1.5%) were found in three healthy individuals. In exon 10, the V allele (56.1%) was slightly more frequent than the M allele (43.9%), and the M/V (45.5%) was the dominant genotype in these individuals. The three major haplotypes T7-(TG)11-V470, T7-(TG)12-M470 and T7-TG11-M470 were related to nearly 86.0% of the population.The polymorphisms of poly-T, TG-repeats, and M470V distribution were similar to those in other East Asians, but they had marked differences in frequency from those single haplotype polymorphisms or linkage haplotypes in Caucasians. Thus, they may be able to explain the low incidence of CF and CF-like diseases in Asians.
- Published
- 2008
11. Structure-activity relationship of pituitary adenylate cyclase activating polypeptide
- Author
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Wei, Mu-Xin, primary, Naruse, S, additional, Nokihara, K, additional, Ozaki, T, additional, Ando, E, additional, and Wray, V, additional
- Published
- 1996
- Full Text
- View/download PDF
12. Structure-activity relationship of pituitary adenylate cyclase activating polypeptide
- Author
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Eiji Ando, Victor Wray, Kiyoshi Nokihara, Mu-Xin Wei, Tsuyoshi Ozaki, and Satoru Naruse
- Subjects
Biochemistry ,Chemistry ,Gastroenterology ,Structure–activity relationship ,Adenylate kinase ,General Medicine ,Cyclase - Published
- 1996
13. Study of celiac artery variations and related surgical techniques in gastric cancer.
- Author
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Huang Y, Mu GC, Qin XG, Chen ZB, Lin JL, and Zeng YJ
- Subjects
- Adult, Aged, Blood Loss, Surgical, Celiac Artery abnormalities, Celiac Artery diagnostic imaging, Drainage, Equipment Design, Female, Gastrectomy adverse effects, Gastrectomy instrumentation, Humans, Length of Stay, Lymph Node Excision, Male, Middle Aged, Multidetector Computed Tomography, Operative Time, Retrospective Studies, Risk Factors, Stomach Neoplasms pathology, Surgical Instruments, Time Factors, Treatment Outcome, Ultrasonic Surgical Procedures adverse effects, Ultrasonic Surgical Procedures instrumentation, Vascular Malformations diagnosis, Celiac Artery surgery, Gastrectomy methods, Stomach Neoplasms surgery, Ultrasonic Surgical Procedures methods, Vascular Malformations complications
- Abstract
Aim: To investigate celiac artery variations in gastric cancer patients and the impact on gastric cancer surgery, and also to discuss the value of the ultrasonic knife in reducing the risk caused by celiac artery variations., Methods: A retrospective analysis was conducted to investigate the difference in average operation time, intraoperative blood loss, number of harvested lymph nodes, average postoperative drainage within 3 d, and postoperative hospital stay between the group with vascular variations and no vascular variations, and between the ultrasonic harmonic scalpel and conventional electric scalpel surgery group., Results: One hundred and fifty-eight cases presented with normal celiac artery, and 80 presented with celiac artery variation (33.61%). The average operation time, blood loss, average drainage within 3 d after surgery in the celiac artery variation group were significantly more than in the no celiac artery variation group (215.7 ± 32.7 min vs 204.2 ± 31.3 min, 220.0 ± 56.7 mL vs 163.1 ± 52.3 mL, 193.6 ± 41.4 mL vs 175.3 ± 34.1 mL, respectively, P < 0.05). In celiac artery variation patients, the average operation time, blood loss, average drainage within 3 d after surgery in the ultrasonic harmonic scalpel group were significantly lower than in the conventional electric scalpel surgery group (209.5 ± 34.9 min vs 226.9 ± 29.4 min, 207.5 ± 57.1 mL vs 235.6 ± 52.9 mL, 184.4 ± 38.2 mL vs 205.0 ± 42.9 mL, respectively, P < 0.05), and the number of lymph node dissections was significantly higher than in the conventional surgery group (25.5 ± 9.2 vs 19.9 ± 7.8, P < 0.05)., Conclusion: Celiac artery variation increases the difficulty and risk of radical gastrectomy. Preoperative imaging evaluation and the application of ultrasonic harmonic scalpel are conducive to radical gastrectomy.
- Published
- 2015
- Full Text
- View/download PDF
14. Mechanism involved in Danshen-induced fluid secretion in salivary glands.
- Author
-
Wei F, Wei MX, and Murakami M
- Subjects
- Animals, Calcium metabolism, Dose-Response Relationship, Drug, Male, Oxygen Consumption drug effects, Phytotherapy, Plant Roots, Plants, Medicinal, Rats, Wistar, Signal Transduction drug effects, Sodium-Potassium-Exchanging ATPase metabolism, Solute Carrier Family 12, Member 2 metabolism, Submandibular Gland metabolism, Time Factors, Drugs, Chinese Herbal pharmacology, Saliva metabolism, Salivation drug effects, Salvia miltiorrhiza, Submandibular Gland drug effects
- Abstract
Aim: Danshen's capability to induce salivary fluid secretion and its mechanisms were studied to determine if it could improve xerostomia., Methods: Submandibular glands were isolated from male Wistar rats under systemic anesthesia with pentobarbital sodium. The artery was cannulated and vascularly perfused at a constant rate. The excretory duct was also cannulated and the secreted saliva was weighed in a cup on an electronic balance. The weight of the accumulated saliva was measured every 3 s and the salivary flow rate was calculated. In addition, the arterio-venous difference in the partial oxygen pressure was measured as an indicator of oxygen consumption. In order to assess the mechanism involved in Danshen-induced fluid secretion, either ouabain (an inhibitor of Na(+)/K(+) ATPase) or bumetanide (an inhibitor of NKCC1) was additionally applied during the Danshen stimulation. In order to examine the involvement of the main membrane receptors, atropine was added to block the M₃ muscarinic receptors, or phentolamine was added to block the α₁ adrenergic receptors. In order to examine the requirement for extracellular Ca(2+), Danshen was applied during the perfusion with nominal Ca(2+) free solution., Results: Although Danshen induced salivary fluid secretion, 88.7 ± 12.8 μL/g-min, n = 9, (the highest value around 20 min from start of DS perfusion was significantly high vs 32.5 ± 5.3 μL/g-min by carbamylcholine, P = 0.00093 by t-test) in the submandibular glands, the time course of that secretion differed from that induced by carbamylcholine. There was a latency associated with the fluid secretion induced by Danshen, followed by a gradual increase in the secretion to its highest value, which was in turn followed by a slow decline to a near zero level. The application of either ouabain or bumetanide inhibited the fluid secretion by 85% or 93%, and suppressed the oxygen consumption by 49% or 66%, respectively. These results indicated that Danshen activates Na(+)/K(+) ATPase and NKCC1 to maintain Cl(-) release and K(+) release for fluid secretion. Neither atropine or phentolamine inhibited the fluid secretion induced by Danshen (263% ± 63% vs 309% ± 45%, 227% ± 63% vs 309% ± 45%, P = 0.899, 0.626 > 0.05 respectively, by ANOVA). Accordingly, Danshen does not bind with M₃ or α₁ receptors. These characteristics suggested that the mechanism involved in DS-induced salivary fluid secretion could be different from that induced by carbamylcholine. Carbamylcholine activates the M₃ receptor to release inositol trisphosphate (IP3) and quickly releases Ca(2+) from the calcium stores. The elevation of [Ca(2+)]i induces chloride release and quick osmosis, resulting in an onset of fluid secretion. An increase in [Ca(2+)]i is essential for the activation of the luminal Cl(-) and basolateral K(+) channels. The nominal removal of extracellular Ca(2+) totally abolished the fluid secretion induced by Danshen (1.8 ± 0.8 μL/g-min vs 101.9 ± 17.2 μL/g-min, P = 0.00023 < 0.01, by t-test), suggesting the involvement of Ca(2+) in the activation of these channels. Therefore, IP₃-store Ca(2+) release signalling may not be involved in the secretion induced by Danshen, but rather, there may be a distinct signalling process., Conclusion: The present findings suggest that Danshen can be used in the treatment of xerostomia, to avoid the systemic side effects associated with muscarinic drugs.
- Published
- 2015
- Full Text
- View/download PDF
15. Histological changes of gastric mucosa after Helicobacter pylori eradication: a systematic review and meta-analysis.
- Author
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Kong YJ, Yi HG, Dai JC, and Wei MX
- Subjects
- Anti-Bacterial Agents therapeutic use, Comorbidity, Disease Progression, Gastritis, Atrophic pathology, Helicobacter pylori, Humans, Intestinal Diseases pathology, Metaplasia pathology, Stomach microbiology, Stomach Diseases pathology, Gastric Mucosa microbiology, Helicobacter Infections drug therapy, Helicobacter Infections microbiology, Intestinal Diseases microbiology, Metaplasia microbiology, Stomach Diseases microbiology
- Abstract
Aim: To systematically review pathological changes of gastric mucosa in gastric atrophy (GA) and intestinal metaplasia (IM) after Helicobacter pylori (H. pylori) eradication., Methods: A systematic search was made of PubMed, Web of Science, EMBASE, ClinicalTrials.gov, OVID and the Cochran Library databases for articles published before March 2013 pertaining to H. pylori and gastric premalignant lesions. Relevant outcomes from articles included in the meta-analysis were combined using Review Manager 5.2 software. A Begg's test was applied to test for publication bias using STATA 11 software. χ(2) and I(2) analyses were used to assess heterogeneity. Analysis of data with no heterogeneity (P > 0.1, I (2) < 25%) was carried out with a fixed effects model, otherwise the causes of heterogeneity were first analyzed and then a random effects model was applied., Results: The results of the meta-analysis showed that the pooled weighted mean difference (WMD) with 95%CI was 0.23 (0.18-0.29) between eradication and non-eradication of H. pylori infection in antral IM with a significant overall effect (Z = 8.19; P <0.00001) and no significant heterogeneity (χ(2) = 27.54, I(2) = 16%). The pooled WMD with 95%CI was -0.01 (-0.04-0.02) for IM in the corpus with no overall effect (Z = 0.66) or heterogeneity (χ(2) = 14.87, I(2) =0%) (fixed effects model). In antral GA, the pooled WMD with 95% CI was 0.25 (0.15-0.35) with a significant overall effect (Z = 4.78; P < 0.00001) and significant heterogeneity (χ(2) = 86.12, I(2) = 71%; P < 0.00001). The pooled WMD with 95% CI for GA of the corpus was 0.14 (0.04-0.24) with a significant overall effect (Z = 2.67; P = 0.008) and significant heterogeneity (χ(2) = 44.79, I(2) = 62%; P = 0.0003) (random effects model)., Conclusion: H. pylori eradication strongly correlates with improvement in IM in the antrum and GA in the corpus and antrum of the stomach.
- Published
- 2014
- Full Text
- View/download PDF
16. Effects of early enteral nutrition on immune function of severe acute pancreatitis patients.
- Author
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Sun JK, Mu XW, Li WQ, Tong ZH, Li J, and Zheng SY
- Subjects
- Acute Disease, Adult, Biomarkers blood, C-Reactive Protein metabolism, CD4-CD8 Ratio, Chi-Square Distribution, China, Enteral Nutrition adverse effects, Enteral Nutrition mortality, Female, HLA-DR Antigens blood, Hospital Mortality, Humans, Immunocompetence, Immunocompromised Host, Immunoglobulin A blood, Immunoglobulin G blood, Inflammation Mediators blood, Male, Middle Aged, Pancreatitis blood, Pancreatitis diagnosis, Pancreatitis immunology, Pancreatitis mortality, Prospective Studies, Severity of Illness Index, Time Factors, Treatment Outcome, Enteral Nutrition methods, Pancreatitis therapy
- Abstract
Aim: To investigate the effects of early enteral nutrition (EEN) on the immune function and clinical outcome of patients with severe acute pancreatitis (SAP)., Methods: Patients were randomly allocated to receive EEN or delayed enteral nutrition (DEN). Enteral nutrition was started within 48 h after admission in EEN group, whereas from the 8(th) day in DEN group. All the immunologic parameters and C-reactive protein (CRP) levels were collected on days 1, 3, 7 and 14 after admission. The clinical outcome variables were also recorded., Results: Sixty SAP patients were enrolled to this study. The CD4+ T-lymphocyte percentage, CD4+/CD8+ ratio, and the CRP levels in EEN group became significantly lower than in DEN group from the 7(th) day after admission. In contrast, the immunoglobulin G (IgG) levels and human leukocyte antigen-DR expression in EEN group became significantly higher than in DEN group from the 7(th) day after admission. No difference of CD8+ T-lymphocyte percentage, IgM and IgA levels was found between the two groups. The incidences of multiple organ dysfunction syndrome, systemic inflammatory response syndrome, and pancreatic infection as well as the duration of intensive care unit stay were significantly lower in EEN group than in DEN group. However, there was no difference of hospital mortality between the two groups., Conclusion: EEN moderates the excessive immune response during the early stage of SAP without leading to subsequent immunosuppression. EEN can improve the clinical outcome, but not decrease the hospital mortality of SAP patients.
- Published
- 2013
- Full Text
- View/download PDF
17. Characteristics of saliva secreted by patients with TCM-Piyinxu.
- Author
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Guan XZ, Wei MX, Chen DZ, Gu YC, Sun ZH, and Bei SY
- Abstract
Aim: To investigate various characteristics of saliva secreted by patients with TCM-Piyinxu (Spleen-yin deficiency)., Methods: Twenty-five individuals with Piyinxu (15 males and 10 females; age range 26-70 years, mean age = 45 years) diagnosed based on criteria used in traditional Chinese medicine, were compared with 20 individuals with Shenyinxu (Kidney-yin deficiency) (11 males, 9 females; age range 35-75 years, mean age = 50) and 30 normal individuals (17 males, 13 females; age range 35-65 years, mean age = 49 years). After acid stimulation, the saliva flow in each group was measured, and the levels of amylase and protein in saliva were determined using an automatic biochemical analyzer. The resultant data were analyzed using the Kruskal-Wallis test and one-way factorial ANOVA test., Results: The flow rates of saliva and amylase in Piyinxu patients (0.27 ± 0.016 mL/min and 2134.13 ± 343.51 IU/min, respectively) were lower than those in normal subjects (0.46 ± 0.027 mL/min and 3501.63 ± 1099.63 IU/min, respectively, P < 0.01), but higher than those in the Shenyinxu group (0.13 ± 0.051 mL/min and 951.62 ± 383.17 IU/min, respectively, P < 0.01). The three groups showed no significant difference in their level of total salivary protein (Piyinxu group, 3.07 ± 0.60 g/L; Shenyinxu group, 3.01 ± 0.90 g/L, and control group, 2.94 ± 1.13 g/L, P = 0.869), amount of amylase per saliva volume, or their ratio of amylase to protein in secreted saliva (P = 0.173 and P = 0.436, respectively)., Conclusion: Piyinxu patients showed altered rates of saliva and amylase secretion when compared with those parameters in patients with Shenyinxu and normal subjects.
- Published
- 1997
- Full Text
- View/download PDF
18. Preliminary study on the pathological model of Piyinxu in rats.
- Author
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Chen DZ and Wei MX
- Abstract
Aim: To study the method of constructing a pathological model of Piyinxu (spleen-yin deficiency) using Sprague-Dawley rats and to make preliminary observations., Methods: Folium sennae (0.8 g) and tabellae thyroidei (80 mg) were given daily by stomach feeding to each rat for 12 d to establish the pathological model of Piyinxu. The activity of the rats and the characteristics of their stool were observed., Results: We observed not only the symptoms of Pixu, such as diarrhea, poor appetite, abdominal distention, weight loss, but also Yinxuneire (endogenous heat), such as increase in water drinking, nervousness, and restlessness. These symptoms were all different from that of the control group of Piyangxu (spleen-yang deficiency)., Conclusion: Combining folium sennae and tabellae thyroidei is an effective method for establishing a pathological model of Piyinxu.
- Published
- 1997
- Full Text
- View/download PDF
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