1. Screening programs for renal cell carcinoma: a systematic review by the EAU young academic urologists renal cancer working group.
- Author
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Diana, Pietro, Klatte, Tobias, Amparore, Daniele, Bertolo, Riccardo, Carbonara, Umberto, Erdem, Selcuk, Ingels, Alexandre, Kara, Onder, Marandino, Laura, Marchioni, Michele, Muselaers, Stijn, Pavan, Nicola, Pecoraro, Angela, Pecoraro, Alessio, Roussel, Eduard, and Campi, Riccardo
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MEDICAL screening , *RENAL cancer , *RENAL cell carcinoma , *UROLOGISTS , *CANCER education , *MEDICAL literature - Abstract
Purpose: To systematically review studies focused on screening programs for renal cell carcinoma (RCC) and provide an exhaustive overview on their clinical impact, potential benefits, and harms. Methods: A systematic review of the recent English-language literature was conducted according to the European Association of Urology guidelines and the PRISMA statement recommendations (PROSPERO ID: CRD42021283136) using the MEDLINE, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov databases. Risk-of-bias assessment was performed according to the QUality In Prognosis Studies (QUIPS) tool. Results: Overall, nine studies and one clinical trials were included. Eight studies reported results from RCC screening programs involving a total of 159 136 patients and four studies reported screening cost-analysis. The prevalence of RCC ranged between 0.02 and 0.22% and it was associated with the socio-demographic characteristics of the subjects; selection of the target population decreased, overall, the screening cost per diagnosis. Conclusions: Despite an increasing interest in RCC screening programs from patients and clinicians there is a relative lack of studies reporting the efficacy, cost-effectiveness, and the optimal modality for RCC screening. Targeting high-risk individuals and/or combining detection of RCC with other health checks represent pragmatic options to improve the cost-effectiveness and reduce the potential harms of RCC screening. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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