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Your search keyword '"Shima N"' showing total 5 results
Start Over Author "Shima N" Journal xenobiotica
5 results on '"Shima N"'

1. Urinary excretion of the main metabolites of 3,4-methylenedioxymethamphetamine (MDMA), including the sulfate and glucuronide of 4-hydroxy-3-methoxymethamphetamine (HMMA), in humans and rats

Author

Shima, N., primary, Katagi, M., additional, Kamata, H., additional, Zaitsu, K., additional, Kamata, T., additional, Nishikawa, M., additional, Miki, A., additional, Tsuchihashi, H., additional, Sakuma, T., additional, and Nemoto, N., additional more...

Published
2008
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5. Urinary excretion of the main metabolites of methamphetamine, including p -hydroxymethamphetamine-sulfate and p -hydroxymethamphetamine-glucuronide, in humans and rats.

Author

Shima, N., Kamata, H. T., Katagi, M., and Tsuchihashi, H.

Subjects
*METHAMPHETAMINE, *EXCRETION, *METABOLITES, *LABORATORY rats, *URINALYSIS, *GLUCURONIDES, *MASS spectrometry, *SULFATES, *LIQUID chromatography
Abstract

The urinary concentrations of the main metabolites of methamphetamine (MA), specifically p -hydroxymethamphetamine-sulfate (   p -OHMA-Sul) and p -hydroxymethamphetamine-glucuronide (   p -OHMA-Glu), were directly measured in MA users and rats using an optimized LC-ESI MS method. The concentrations of the two conjugates in 50 MA human users’ urine ranged from 0.09 to 88.6  µM (0.02–21.7  µg  ml -1 ) for p -OHMA-Sul and from 99%) was excreted as the glucuronide in urine. These findings confirm that a large species variation exists in the conjugation of p -OHMA between humans and rats. [ABSTRACT FROM AUTHOR] more...

Published
2006
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