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Background: Quality of health care includes some degree of services provided to individuals and communities to increase the likelihood of desired results and are updated in accordance with professional knowledge. To assess the quality of services provided in hospitals, indicators and performance standards are needed to be identified, because these indicators are the structure of the hospital evaluation. This study aimed to determine the performance indicators in general- public hospitals in area of quality and effectiveness and prioritization of these indicators. Materials and Methods: This descriptive-qualitative and practical research was done through a systematic review of literature and data were obtained from the hospital authorities. In order to prioritize public hospital performance indicators, Analytic Hierarchy Process (AHP) was used and the results were analyzed by the Expert Choice software. Results: In the field of quality and effectiveness, 73 performance indicators were considering at various texts. Indicators such as the rate of hospital infections (100%), the incidence of hospital events (72%), Net hospital mortality(63%), Percentage of patients' satisfaction(53%) selected as key performance indicators. Conclusion: Performance indicators in the field of quality and effectiveness has important place in health system and hospital organization. By evaluating the quality of services in health centers, the problems and shortcomings can be seen, and consequently analyzing information can lead to a try to reduce them.