1. Chemical composition of the essential oil of Phlomis linearis Boiss.Bal., and biological effects on the CAM-assay: a safety evaluation
- Author
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Mehmet Yaşar Dadandi, D. H. Paper, Kemal Hüsnü Can Başer, Betül Demirci, Gerhard Franz, Anadolu Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Demirci, Betül, and Başer, K. Hüsnü Can
- Subjects
Turkey ,General Biochemistry, Genetics and Molecular Biology ,Gas Chromatography-Mass Spectrometry ,law.invention ,Phlomis ,Sesquiterpenes, Germacrane ,law ,Allantois ,Botany ,Oils, Volatile ,Animals ,Phlomis Linearis ,Cam-Assay ,Chemical composition ,Phlomis linearis ,Essential oil ,Polycyclic Sesquiterpenes ,biology ,Traditional medicine ,Chemistry ,Anti-Inflammatory Agents, Non-Steroidal ,Biological activity ,Chorion ,biology.organism_classification ,Essential Oil ,Lamiaceae ,Cattle ,Gas chromatography–mass spectrometry ,Hydro distillation ,Cam assay ,Sesquiterpenes - Abstract
WOS: 000188262800014, PubMed ID: 14713159, Phlomis linearis Boiss. & Bal. of the Lamiaceae family growing in central, east and southeast Anatolia is an endemic species for Turkey. The essential oil obtained from the aerial parts by hydro distillation was subsequently analyzed by GC/MS. The main components of the oil were found as beta-caryophyllene (24.2%), germacrene D (22.3%) and caryophyllene oxide (9.2%), among 49 identified compounds, representing 94.5% of the total essential oil. The overall biological activity of the essential oil (100 mug/pellet) was tested on the chorioallantoic membrane (CAM) of the fertilized hen's egg in order to examine the anti-angiogenic and anti-inflammatory activity. None of the tests showed pronounced activity, toxicity or irritation at the tested concentration.
- Published
- 2004