1. [Role of NF-κB inhibitor in Acute Myeloid Leukemia]
- Author
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Wei-Li, Wang, Qiao-Zhu, Xu, Xiao-Huan, Mu, Le, Wang, Li-Yan, Zhang, Jing, Xu, Ying-Dai, Gao, Tao, Cheng, and Wei-Ping, Yuan
- Subjects
Leukemia, Myeloid, Acute ,Mice ,Tumor Necrosis Factor Ligand Superfamily Member 14 ,Bone Marrow ,Cell Cycle ,NF-kappa B ,Transcription Factor RelA ,Animals ,Humans ,Apoptosis ,Hematopoietic Stem Cells ,Signal Transduction - Abstract
To investigate the role of NF-κB inhibitor in occurence and development of AML.AML and normal bone marrow samples were collected from 8 AML patients and 8 normal persons. The expression of NF-κB signaling pathway genes was detected by NF-κB PCR array. Then, AML mouse model was constructed to test the role of NF-κB inhibitor in AML.The NF-κB signal pathway was activated in AML patients. The up-regulated genes, EDARADD, TNFSF14, could activate the NF-κB signal pathway, IL6 could regulate the inflammatory signal. The down-regulated genes, TNFRSF 10B, TNFRSF1A, could lead to cell apoptosis. the AML mouse model was constructed successfully. Then administration of NF-κB inhibitor reduced the inhibition of leukemia niche to the normal hematopoietic stem cells (HSCs), promoted the HSC to enter into cell cycle.The NF-κB signal pathway is activated in AML cells. AML mouse model is constructed successfully. NF-κB inhibitor has a potential to treat AML and promotes the HSC to enrter into cell cycle.
- Published
- 2016