1. [Relationship between NK Cell Reconstitution and aGVHD after Allo-HSCT]
- Author
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Lu-Lu, Wan, Jian-Lin, Chen, Chen, Xu, Bo-Tao, Li, Jiang-Wei, Hu, Xiao, Lou, Fan, Yang, Na, Liu, Yong-Feng, Su, San-Chun, Lan, Qing-Han, Wang, Zhuo-Qing, Qiao, Lei, Wang, Min, Jiang, Yu-Hang, Li, and Liang-Ding, Hu
- Subjects
Killer Cells, Natural ,Incidence ,Hematopoietic Stem Cell Transplantation ,Graft vs Host Disease ,Humans ,Disease-Free Survival - Abstract
To investigate the relationship between NK cell count/activity and acute graft-versus-host disease (aGVHD) in patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT).A total of 26 patients who had undergone allo-HSCT from January to July 2015 were enrolled in this study. The NK cell count/activity in the peripheral blood of recipients on day 30 after allo-HSCT were monitored by using 4-color flow cytometry. The incidence of aGVHD in patients was evaluated by clinical manifestation combinating with related pathologic indicators, and the relationship between NK cell count/activity and aGVHD were analyzed.In the aGVHD group and the no-aGVHD group, the NK cell count and activity on days 30 after allo-HSCT were 655±216 cells/µl vs 1169±372 cells/µl(P=0.002) and 7.3±3.6% vs 9.0±3.6% (P=0.008). In the II-IV grade aGVHD group and the 0-I grade aGVHD group, the NK cell count/activity were 617±220 cells/µl vs 1081±399 cells/µl (P=0.001) and 4.2±1.7% vs 8.3±3.5%(P=0.001). As compared with the 0-I grade aGVHD group, patients in the II-IV grade aGVHD group had higher relapse rate (57% vs 5%)(P=0.010) , lower 1-year progression-free survival(PFS) rate (43% vs 84%)(P=0.010).NK cell count/activity on day 30 after allo-HSCT were closely relates with aGVHD, which may be a potential marker for aGVHD and can provide a new target for aGVHD therapy.
- Published
- 2017