1. [Effects of aqueous extract of Hedysarum austrosibiricum on metabolism of oxyen free radicals in subacute aging mice caused by D-galactose].
- Author
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Hailiqian T, Kang JS, and Sun L
- Subjects
- Aging metabolism, Animals, Antioxidants isolation & purification, Brain drug effects, Brain metabolism, Drugs, Chinese Herbal isolation & purification, Female, Free Radical Scavengers isolation & purification, Free Radicals metabolism, Galactose toxicity, Glutathione Peroxidase metabolism, Liver drug effects, Liver metabolism, Malondialdehyde metabolism, Mice, Monoamine Oxidase metabolism, Plant Extracts isolation & purification, Plant Extracts pharmacology, Plant Roots chemistry, Random Allocation, Superoxide Dismutase metabolism, Aging drug effects, Antioxidants pharmacology, Drugs, Chinese Herbal pharmacology, Fabaceae chemistry, Free Radical Scavengers pharmacology
- Abstract
Objective: To investigate the anti-aging effect of aqueous extract of Hedysarum austrosibiricum cultivated in Xin-jiang., Method: Subacute aging model in mice was established by D-galactose (D-gal) and activities of SOD and GSH-PX, contents of MDA in brain and liver tissues, activities of MAO in brain tissue and immune indexes were determined., Result: Aqueous extract of H. austrosibiricum Xinjiang markedly increased the activities of SOD and GSH-PX, significantly decreased contents of MDA in brain and liver tissues. MAO activities in brain tissue were also decreased. It also elevated the spleen and thymus indexes., Conclusion: Aqueous extract of H. austrosibiricum might have anti-aging effect, which is implemented by eliminating oxyen free radicals, rising activities
- Published
- 2007