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Your search keyword '"Nucleic Acids pharmacology"' showing total 8 results
Start Over Descriptor "Nucleic Acids pharmacology" Journal zhurnal mikrobiologii epidemiologii i immunobiologii
8 results on '"Nucleic Acids pharmacology"'

1. [The effect of sodium nucleinate on the population characteristics of Streptococcus groups A and C].

Author

Khodyrev AP, Feĭgel'man BI, Shashkova NM, and Nemirovich-Danchenko MM

Subjects
Animals, Lethal Dose 50, Mice, Streptococcus enzymology, Streptococcus growth & development, Streptococcus pathogenicity, Streptococcus pyogenes enzymology, Streptococcus pyogenes growth & development, Streptococcus pyogenes pathogenicity, Streptokinase analysis, Streptokinase drug effects, Streptokinase metabolism, Time Factors, Virulence drug effects, Nucleic Acids pharmacology, RNA, Fungal pharmacology, Streptococcus drug effects, Streptococcus pyogenes drug effects
Abstract

The influence of sodium nucleinate on the growth kinetics, streptokinase activity and virulence of streptococcal populations, groups A and C, was studied. As revealed in these studies, the kinetics of the growth of the populations of both strains in the exponential phase did not depend on the concentration of sodium nucleinate in the culture medium. Measurements made on hours 15, 20 and 24 of growth showed the presence of close, direct and statistically significant correlation between the content of biomass, as well as streptokinase activity and specific streptokinase activity, and the concentration of sodium nucleinate in the culture medium. On the basis of the calculation of the coefficients of determination, the main part (70-96%) of the total dispersion of each of the above-mentioned characteristics dispersion of each of the above-mentioned characteristics could be attributed to variations in the concentration of sodium nucleinate. Five passages of faintly virulent streptococcal strains, groups A and C, were not accompanied by a rise in their virulence.

Published
1990

2. [Comparative study of murine B-cells obtained by 2 different methods proliferating long-term in vitro].

Author

Volgareva GM, Vlasov GS, Kil'diushevskaia TV, and Zvenigorodskaia VP

Subjects
Animals, Antibodies, Bacterial biosynthesis, Antibodies, Monoclonal biosynthesis, Antibody Specificity, B-Lymphocytes drug effects, B-Lymphocytes immunology, Cell Division drug effects, Cell Line, Cell Separation methods, Hybridomas cytology, Hybridomas drug effects, Hybridomas immunology, Immunization, Mice, Mice, Inbred BALB C, Multiple Myeloma immunology, Neisseria meningitidis immunology, Nucleic Acids pharmacology, Spleen cytology, Spleen drug effects, Spleen immunology, Time Factors, B-Lymphocytes cytology
Abstract

The hybridization of myeloma cells NP with lymphocytes of mice, immunized with protein isolated from Neisseria meningitidis strain Bc5 in a single injection into the spleen 3 days prior to fusion, made it possible to obtain 25-72% of hybridomas secreting antibodies to meningococcal antigens. The treatment of immune lymphocytes from these mice with the total preparations of nucleic acids, isolated by the phenol-detergent method from mouse myeloma cells NP and NS/0, induced an increase in the proliferative activity of lymphocytes; in some microcultures multilayer cell growth was observed on the bottom of the wells, whereas in the control microcultures such growth was absent. No synthesis of specific antibodies was detected in the cultures of lymphocytes whose proliferation was stimulated with nucleic acids.

Published
1988

3. [Biodynamic nongenetical effects of nucleic acids].

Author

Zemskov MV

Subjects
DNA, Bacterial pharmacology, RNA, Fungal pharmacology, Staphylococcus pathogenicity, Streptococcus metabolism, Streptococcus pathogenicity, Virulence drug effects, Nucleic Acids pharmacology
Published
1982

4. [The development of experimental and clinical research on low-molecular RNA].

Author

Zemskov AM and Zemskov VM

Subjects
Adjuvants, Immunologic, Animals, Cell Membrane drug effects, Dose-Response Relationship, Drug, Drug Evaluation, Drug Evaluation, Preclinical, Drug Interactions, Drug Therapy, Combination, Humans, Immunity drug effects, Molecular Weight, Nucleic Acids pharmacology, Nucleic Acids therapeutic use, Nucleic Acids toxicity, RNA, Fungal therapeutic use, RNA, Fungal toxicity, Research, RNA, Fungal pharmacology
Published
1987

5. [Stimulation of replication and increase in virulence of Shigella growing in RNA-containing media].

Author

Zemskov MV, Gavrilov SN, and Zemskov AM

Subjects
Animals, Bacterial Proteins metabolism, Culture Media, DNA, Bacterial metabolism, Humans, Mice, RNA, Bacterial metabolism, Shigella flexneri metabolism, Shigella flexneri pathogenicity, Shigella sonnei metabolism, Shigella sonnei pathogenicity, Stimulation, Chemical, Virulence, Nucleic Acids pharmacology, RNA, Fungal pharmacology, Shigella flexneri growth & development, Shigella sonnei growth & development
Published
1983

6. [Redistribution and activation of peritoneal macrophages with the peroral use of sodium nucleinate].

Author

Zemskov VM, Rodionov SV, and Pantin VI

Subjects
Animals, Ascitic Fluid pathology, Macrophages enzymology, Macrophages immunology, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Oxidative Phosphorylation drug effects, Receptors, Fc drug effects, Receptors, Fc immunology, Time Factors, Adjuvants, Immunologic pharmacology, Macrophage Activation drug effects, Macrophages drug effects, Nucleic Acids pharmacology
Abstract

Three hours after the administration of sodium nucleinate the activation of glycolysis, the hexosomonophosphate shunt, the urea cycle (determined by the analysis of key enzymes), the expression of FC gamma-receptors and the decrease of oxidizing phosphorylation were noted in the peritoneal macrophages of mice. By 36 hours the gradual decrease of these characteristics occurred. After three oral administrations of the preparation immature macrophages with lower metabolic activity and increased oxidizing phosphorylation appeared in the exudate, while resident and activated cells practically disappeared. The immaturity of the cells was confirmed by their incubation in vitro. The changes in the cells, revealed in this investigation, are supposed to occur due to the redistribution of activated and intact macrophage populations in situ.

Published
1985

8. [The role of nucleic acids in infection and immunity (review of the literature)].

Author

Zemskov VM

Subjects
Animals, Bacteria drug effects, Bacteria immunology, C-Reactive Protein, DNA, Bacterial, Leukocytes, Mice, RNA, Bacterial pharmacology, Radiation Injuries, Experimental immunology, Transformation, Genetic, Virus Diseases complications, Yeasts, Antibody Formation, Infections immunology, Nucleic Acids metabolism, Nucleic Acids pharmacology, Nucleic Acids physiology
Published
1970

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