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Background: This study assessed the effects of hypnotherapy in conjunction with pharmacotherapy versus pharmacotherapy on the quality of life in patients diagnosed with irritable bowel syndrome (IBS). Materials and Methods: This clinical trial used the convenience sampling method to enroll 34 IBS patients. Patients were selected according to Rome III criteria and divided into two groups: i) hypnotherapy plusstandard medical treatmentand ii) standard medical treatment. The QOL-IBS scale assessed patient quality of life at baseline, post-treatment and at the six month follow-up. Data were analyzed using analysis of covariance (ANCOVA). Results: There were significant differences observed between both groups at the post-treatment and follow-up stages in terms of quality of life (p<0.05). Conclusion: Standard medical treatment in addition to hypnotherapy can be used to improve quality of life in IBS patients. [ABSTRACT FROM AUTHOR]