1. clinicopathological evaluation of some immunostimulants' effects in Barki lambs
- Author
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Asmaa A. Darwish and Mohamed F. Eldakroury
- Subjects
hematology ,biochemistry ,bcg ,levamisole ,vitamin e ,Veterinary medicine ,SF600-1100 - Abstract
Levamisole, BCG, vitamin E & Selenium are traditional immunopotentiating agents. This study aimed to monitor and compare between their effects on some clinicopathological and immunological parameters. For this purpose, sixty clinically-healthy 6-months Barki male lambs were equally divided into three groups: The first group was injected S/C with l ml of levapan®10% /50kg B.Wt (100 mg of levamisole) for 3 consecutive days, while the second group was injected S/C with 0.1 ml of BCG vaccine, and the third group was injected S/C for one time with E and Se 0.5 ml /10 kg B. Wt. Blood samples were collected at 0, 3, 7, 14, 21, and 35 days. Clinicopathological and immunological parameters were estimated and statistically analyzed. The three groups displayed a significant enhancement in the estimated immunological parameters (elevated neutrophils count, neutrophils phagocytic activity and index, globulin, and acute phase proteins), but the BCG group had the highest degree of immunopotentiating action for a longer time. The E and Se group and levamisole group were almost equal. On the other hand, the erthyrogram, total antioxidant capacity, liver and kidney functions with the BCG, and levamisole groups were negatively affected, while they were enhanced in the E and Se group for 14 days. In addition, the iron profile showed significant hypoferremia, hypotransferrinemia, and hyperferritinemia with the BCG group, and non-significant changes with both, the levamisole and E and Se groups. We concluded that the BCG has a powerful and sustainable immunomodulatory effect and it is recommended to inject it combined with E and Se to avoid its side effects.
- Published
- 2023
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