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The cytokine release syndrome is a systemic inflammatory response as a result of a underlying disease or it could be yatrogenic, most common as result of immunotherapy for oncological diseases. This overview examines clinical characteristics as well etiological factors and the differential diagnosis of the cytokine release syndrome Treatment of the condition is etiologically for the underlying disease but also symptomatic, which includes a wide range of antiinterleukin drugs, such as anti IL 6 antibodies, anti IL1 antibodies, anti-gamma interferon antibodies. This overview examines the place of this therapies in the contemporary treatment of cytokine release syndrome. [ABSTRACT FROM AUTHOR]