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2. [Our clinical experience in treating endometriosis genitalis externa with the preparation Danoval].

Author

Nalbanski B, Novachkov V, Rachev E, Nikolov A, Stoianov S, Katsarova M, and Maleeva A

Subjects
Adnexal Diseases blood, Adult, Danazol adverse effects, Drug Evaluation, Endometriosis blood, Estradiol blood, Female, Humans, Adnexal Diseases drug therapy, Danazol therapeutic use, Endometriosis drug therapy
Abstract

By means of the serum level of estradiol and the vaginal smear indexes the antigonadotropic activity of the preparation Danoval (2-3-isoxasol-17-ethinyltestosterone) is indirectly evaluated on 15 infertility patients with laparoscopic proved endometriosis. After 5 month's course of treatment with 400 mg daily the level of estradiol decreased from 1.54 to 0.31 nmol/l, IA from 20.8 to 10.4 and IP from 32 to 17.3. The side effects are slight and descend from the pharmacological properties of the preparation. Two patients became pregnant in three months after the treatment.

Published
1993

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