1. [The interaction between lead, cadmium and essential trace elements (an experimental study)].
- Author
-
Khadzhieva I and Kuneva T
- Subjects
- Animals, Cadmium pharmacokinetics, Cadmium Poisoning metabolism, Chronic Disease, Copper metabolism, Drug Interactions, Lead Poisoning metabolism, Liver drug effects, Liver metabolism, Male, Manganese metabolism, Organometallic Compounds pharmacokinetics, Rats, Rats, Wistar, Time Factors, Zinc metabolism, Cadmium toxicity, Cadmium Compounds, Organometallic Compounds toxicity, Sulfates, Trace Elements metabolism
- Abstract
An experimental study is performed on 120 white male Wistar rats with average weight 180-210 g. The animals are distributed in 4 groups. I group--control; II group--animals treated with aqua solution of cadmium sulphate; III group--animals treated with aqua solution of cadmium sulphate and lead acetate simultaneously and IV group--animals treated with aqua solution of lead acetate. The toxic substances are introduced per oral in dose 1/40 of LD50 and for a period of 90 days. The animals are killed by decapitation on the 2, 4, 15, 30 and 90th day from the beginning of treatment. An increased content of cadmium in blood, urine and liver is registered in II and III group of animals, and of lead--in III and IV group animals. The zinc content in liver in group II is increased in comparison with the control group, while in group III and IV remains unchanged. The concentration of zinc in blood in animals from II and III group is increased. There is no deviation in group IV. The copper content in liver is decreased in II, III and IV group. There are no significant deviations in the content of copper in the blood of the examined groups of animals. The level of manganese in liver in II, III and IV group of animals is reduced. No changes in the content of manganese in blood are registered in the examined groups animals.
- Published
- 1992