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The clearance approach was used in the evaluation of the role of renal and biliary excretion in the total elimination of cephothiam from organism of patients after cholecystectomy. Six patients with inserted T-like drain into the choledochus duct and urinary catheter after gall bladder operation received I g cephothiam by stream intravenously during the early postoperative period. The value of renal clearance (= 132.86 +/- 27.35 ml/min) was with one order higher than that of biliary clearance (= 11.54 +/- 9.67 ml/min) and revealed glomerular filtration as the basic mechanism for elimination of cephothiam from the organism of those patients. The value for the sum Clr + Clb = 144.40 ml/min. kre + keb + 1.51 h1-resp. corresponded to the value of the clearance from the central (plasma) compartment, that for kle resp. suggesting that the kidneys and liver were part of that compartment. The high degree of positive correlation between the biliary clearance and biliary flow (r = 0.94, p less than or equal to 0.02) as well as the positive dependence of the biliary excretory rates, biliary excretory rate constants resp X 80, (r = 0.81, r = 0.83 resp) from the biliary flow revealed that the elimination of the drug from the live depends on the volume of the biliary flow. The negative correlation (r = -0.87, p less than 0.05) between the half-life for biliary excretion and the volume of the biliary flow support that presumption.

The pharmacokinetic behaviour of cephalosporin antibiotic, second generation after intravenous administration to patients during the early post-operative period was characterized as well as after cholecystectomy. The data suggest a two-compartment distribution with elimination from the central compartment, realized on account of the renal way of clearance. In one of the patients, with one-compartment distribution of the drug, the presence of the theoretical determining factors in "the collapse" of one two-compartment open model to one-compartment is shown, associated with clinical characteristics of that patient.

The pharmacokinetic analysis was enriched, during the last several years, with the method of statistical moment (MSM)--an alternative for the classical compartment approach, presumed as model-non-dependent. The advantages of MSM presented are: elimination the necessity of constructing a model in advance and as a result--elaboration of complicated computer programmes. The possibilities of MSM in a comparative aspect with the traditional compartment pharmacokinetic analysis are presented in the present paper, making use of the data about cephalosporin antibiotic cefothiam after intravenous administration to patients after cholecystectomy. The values of the pharmacokinetic parameters studied, evaluated via both methods, did not statistically differ, suggesting the possibility of using MSM method as an alternative method for rapid evaluation of the pharmacokinetic parameters necessary for the elaboration of dose regimes.