1. [Dermatofibrosarcoma protuberans--a clinico-anatomical and immunohistochemical study].
- Author
-
Popkhristova E
- Subjects
- Adolescent, Adult, Aged, Carcinoma, Squamous Cell metabolism, Carcinoma, Squamous Cell pathology, Dermatofibrosarcoma metabolism, Histiocytoma, Benign Fibrous metabolism, Histiocytoma, Benign Fibrous pathology, Humans, Immunohistochemistry, Middle Aged, Muramidase metabolism, Neoplasm Recurrence, Local metabolism, Neoplasm Recurrence, Local pathology, S100 Proteins metabolism, Skin Neoplasms metabolism, Soft Tissue Neoplasms metabolism, alpha 1-Antitrypsin metabolism, Dermatofibrosarcoma pathology, Skin Neoplasms pathology, Soft Tissue Neoplasms pathology
- Abstract
This is a report on the clinical, anatomical and immunohistochemical study of thirty patients presenting dermatofibrosarcoma protuberans. Its incidence (4.8 percent), covering a 15-year period in a specialized oncological unit, wider age range and high rate of relapses (66.6 percent) are established as the result of clinical and anatomical revision. The latter findings necessitate radical removal of the neoplasm as early at its primary resection. The practical implications of the so-called "spoke-like" structures, pathognomonic for histological identification of the tumor, are discussed. The immunohistochemical study for S100 [correction of C100] protein and lysozyme is negative, while alpha 1-antitrypsin reaction is positive in single rounded histiocyte-like cells which is by no means a conclusive evidence of the phenotype characteristics of the cell population in dermatofibrosarcoma protuberans.
- Published
- 1996