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The aim of study was to investigate the association between serum levels of IL-12p40 and IL-10 and progression of the colorectal cancer (CRC). Be observed an association between severity of CRC and serum levels of investigated cytokines. IL-12p40 was in the highest level in stage-I (423.6 +/- 224.7 pg/ml) compared to more severe stages. In the opposite direction were the data for immunosuppressive cytokine, IL-10. Patients with stage-IV had the highest level of IL-10 (36.02 +/- 9.5 pg/ml). On the basis of our results we could conclude that IL-12p40 and IL-10 serum levels were associated with tumour progression. More severe stages of CRC are characterized by low IL-12p40 and high IL-10 serum levels.

A Growth-related protein kinase's activity was studied in clinically affected and unaffected psoriatic epidermis. This activity was about 3 fold higher in clinically affected skin. Additionally, the unaffected psoriatic epidermis shows higher activity than the normal one. We conclude that the Growth-related protein kinase might be involved in the pathogenesis of psoriasis.