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Objective To investigate the optimal clinical therapy effects and prognostic factors of cerebral arteriovenous malformation (CAVM) in children following different treatment methods. Methods The clinical data of 47 children (< 18 years old) with CAVM who were admitted to Tianjin Huanhu Hospital from October 2011 to September 2022 were collected, and the multimodality treatment and prognostic factors of different grades were analyzed. Spetzler - Martin grading system and vascular nest dispersion classification were used to evaluate the risk and angiogenesis of CAVM, different treatment modalities such as microsurgery, gamma knife radiosurgery, and multi-mode therapy were used to evaluate the total resection rate, prognosis, and imaging follow-up results. Results 1) Treatment plan: among the total 47 children in this group, 35 (74.47%) received simple microsurgery, of which 10 (28.57%) suffered surgery within one week of hemorrhage, and 25 (71.43%) suffered surgery over one week; 6 (12.77%) received conservative treatment; 3 (6.38%) received gamma knife radiosurgery; 3 (6.38%) received multimodal therapy (microsurgery + interventional embolism/gamma knife radiosurgery). 2) Spetzler - Martin grading and prognosis: among the 38 patients (80.85%) of Spetzler - Martin grade Ⅰ - Ⅲ , 29 (76.32%) underwent microsurgery, one (2.63%) received multimodal therapy, and 2 (5.26%) received gamma knife radiosurgery. The total surgical resection rate was 9/9 in grade Ⅰ, 13/14 in grade Ⅱ and 6/9 in grade Ⅲ. Eight patients (21.05%) had a poor prognosis during 5 years followed-up period. There was one (2.63%) recurrence on imaging follow-up. Among 9 patients whose Spetzler-Martin grade were between Ⅳ and Ⅴ , 6 patients underwent microsurgery, 2 patients received multimodal therapy, and one received gamma knife radiosurgery. Total surgical resection rate was 4/8 in grade Ⅳ and 1/1 in grade Ⅴ, and prognosis was poor in 5 cases. 3) Diffusion classification and prognosis of malformed vascular mass: the total resection rate of dense type was 17/17, and that of diffuse type was 66.67% (16/24). The incidence of poor prognosis was 3/ 18 for dense type and 34.48% (10/29) for diffuse type. Conclusions Microsurgery resection is a relatively safe and effective method for the treatment of CAVM in children. The operation was recommended to be performed at least one week after acute hemorrhage if possible. A preoperative evaluation of surgical risks and the density of abnormal vascular clusters can assist in selecting the best treatment plan, thus could increase the total resection rate of lesions and improve the prognosis.

To observe the effect of black sesame oil lecithin solution on bone metabolism in naturally grown aging mice and compare with vitamin E.8-month-old SPF Kunming mice were randomly divided into normal saline group (NS group),vitamin E group (VE group),black sesame oil group (Oil group).The experiment lasted for 10 weeks.At the end of the experiment,the mice were sacrificed.The right femurs were taken for Micro CT scan,and the left ulna for bone component content determination.Compared with the NS group,the bone calcium and bone magnesium contents in the Oil group were significantly increased,and the SMI was significantly reduced,while BV/TV,Density and Conn-Dens were increased,but the difference was not statistically significant; compared with the VE group,The content of bone calcium and bone magnesium in the Oil group were significantly increased; the three-dimensional map showed that the bone trabeculae were arranged evenly and tightly,with small gaps and good continuity.After 10 weeks of naturally-growing old mice given black sesame oil,the bone mass and microstructure of the femur of the mice increased,suggesting the potential applications for anti-osteoporosis.

Aiming at the problem of image tampering and forensic localization,a fragile watermarking algorithm based on chaos sequence and image QR decomposition was proposed to determine the image tampering.The algorithm chooses QR decomposition to decompose the image,embeds the watermark after the image is decomposed,and encrypts the watermark by chaotic system to enhance the security of the watermark.Experimental results show that the algorithm not only improves the security of the location watermarking algorithm,but also can estimate the tampering strength of the tampered area.

Aiming at the fuzzy operation commonly used in image tampering,a new fuzzy detection scheme using smooth filter preserving edges and mathematical morphological methods was studied.By using the sharpening function and denoising function of both methods,tampering and location of tampering position can be pointed out without embedding information such as watermarking technique.The method can not only determine whether an image has been virtualized,but also detect the extent of the image blur.Experimental results confirm the effectiveness of the scheme.

Objective To investigate the effect of blood pressure patterns on memory function in patients with Parkinson's disease (PD). Methods A total of 68 PD patients were collected from the Department of Neurology of Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) between August 2018 and July 2021. All patients received 24 h ambulatory blood pressure monitoring (ABPM) and were divided into reverse dipping group (n=17), reduced dipping group (n=30), normal group (n=17), and extreme dipping group (n=4) according to the reduction rate of nocturnal systolic blood pressure; nocturnal hypertension group (n=37) and non⁃nocturnal hypertension group (n=31) according to nocturnal blood pressure. Global cognitive function was assessed by Mini⁃Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Memory function was evaluated by Logical Memory Test (LMT), Auditory Verbal Learning Test (AVLT) and Digit Span Test (DST). Results Among the 4 groups with different blood pressure pattern, statistical significances were found in duration (χ2=8.599, P=0.035), AVLT imediate 3 (F=3.100, P=0.033) and AVLT delayed (χ2=7.828, P=0.050). Pairwise comparison showed that the duration was longer in the reverse dipping group (Z=4.224, P=0.043) and the normal group (Z=4.821, P=0.028) than in the reduced dipping group; the AVLT imediate 3 of the reverse dipping group was lower than that of the normal group (t=⁃2.028, P=0.048) and the extreme dipping group (t=⁃2.673, P=0.010); the AVLT imediate 3 of the reduced dipping group was lower than that of the extreme dipping group (t=2.554, P=0.013). Compared with non⁃nocturnal hypertension group, the morbidity of hypertension was higher (χ2=6.399, P=0.011) and the duration was longer (Z=⁃2.008, P=0.045) in the nocturnal hypertension group. There was no significant difference in memory function between 2 groups (P＞0.05, for all). Conclusions PD patients with reverse dipping blood pressure pattern are more likely to influence cognitive function, especially in memory function. Continuous blood pressure monitoring should be performed in PD patients.