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Objective This paper makes a cross-sectional survey about mental depression in patients with disabilities of Wuhua district, Kunming, investigating the depression of patients and the relevant positive rate and discovering the factors, which provides some basis for the psychological therapy for mental depression of the patients. Methods A symptoms of depression self rating scale (SDS) and a self-designed questionnaire for the basic information were adopted in the thorough survey for the patients of physical disabilities who lived in Wuhua district and had the certificates of disabled. Results Of the 1660 patients with physical disabilities, 889 were found with depression and the depression positive rate was 53.55%. The psychomotor ability was the most frequent symptom. The mental depression disorders was the second and the somatoform disorders the third. The least frequent one was mental emotional symptom. Univariate analysis showed that for the depression positive rate, there were some ethnic groups differences and no age, sex and household types difference in the patients. For the depression symptom factors, there were ethnic groups and household types differences, no age and sex differences. Conclusion The positive rate of the patients in the survey was higher than the general population and the other domestic and overseas counterparts. The psychomotor ability was the most frequent symptom. The mental depression disorders was the second and the somatoform disorders the third. The least frequent one was mental emotional symptom. According to the uivariate analysis, the positive rate of the patients might be related to the ethnic groups, and might have no relationship with age, sex and household types. However, the depression symptom factors maybe connected with ethnic groups and household types and irrelevant with age and sex. In conclusion, the present mental health status of the patients with mental depression of Wuhua district, Kunming was not looking good and the paper provides some clues for the psychological rehabilitation therapy for the patients with depression. [ABSTRACT FROM AUTHOR]