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Objective A bibliometric analysis of the literature related to stroke and the blood-brain barrier was conducted to obtain a research map, explore hotspots and trends, and provide references for clinical treatment and research. Methods The literature related to stroke and blood-brain barrier from 1 January 2001 to 28 February 2023 was explored in the Web of Science core database. Using bibliometrics, CiteSpace V6.1.R6 was used to analyze the distribution of years, countries/regions, research institutions/system, authors, publications, cited literature, keywords and research trends. Results A total of 5028 papers were included after screening, with an overall upward trend in the number of published papers. The United States had the most research on this topic, followed by China’s mainland and Germany. Most of the top 10 research institutions/system were from the United States, France and China, with strong collaboration between countries/regions and research institutions/system. Among the authors, Chopp Michael from the United States ranked first with 49 papers. Among the research trends, ischemic stroke, miR-126 in non-coding RNA, blood-brain barrier dysfunction and drug delivery were the hot spots in the last three years. Conclusions Blood-brain barrier and stroke are inextricably linked. The dysfunction and repair mechanism of blood-brain barrier during stroke, the circulation biomarkers released by blood brain barrier and the use of blood-brain barrier opening time to increase drug absorption are worthy of further study [ABSTRACT FROM AUTHOR]

Alcohol use disorder, as the fifth largest risk factor worldwide, is an important component of stroke prevention. In recent years, a large number of epidemiological and clinical studies have shown that there is a correlation between alcohol and stroke. Alcohol can affect cardiovascular and cerebrovascular health through various ways, resulting in stroke and even death. At the same time, some studies have shown that there may be different associations between alcohol and stroke, light drinking may be a cardiovascular and cerebrovascular protective factor, and moderate and heavy drinking may induce and aggravate stroke. This paper analyzed the current prevalence of stroke complicated with alcohol use disorder, reviewed the possible pathogenesis of alcohol use disorder affecting the incidence of stroke, and summarized alcohol intake monitoring biomarkers and treatments related to alcohol use disorder, in order to further explore the correlation between stroke and alcohol use disorder and provide ideas for clinical diagnosis and treatment. [ABSTRACT FROM AUTHOR]

Fibroblast growth factor 23 (FGF23) -Klotho endocrine axis is involved in phosphate metabolism, and is closely related to the pathogenesis of stroke. FGF23 and Klotho levels are associated with the incidence and prognosis of stroke. The FGF23-Klotho endocrine axis is involved in the regulation of vascular inflammation and may be involved in the pathological process of stroke risk factors such as hypertension, insulin resistance, lipid metabolism and obesity. In this paper, the influence and mechanism of FGF23-Klotho endocrine axis on stroke were reviewed in order to bring new ideas for clinical treatment and prevention of stroke. [ABSTRACT FROM AUTHOR]

Post-stroke anxiety disorder (PSA) is a common psychiatric complication of stroke, which jeopardizes patients' recovery and their quality of life. Recent studies suggest that inflammation plays an important role in the pathogenesis of PSA. Therefore, this paper reviewed the related licture about the association between PSA and serum inflammatory biomarkers in order to provide references for the intervention of PSA. In this study, a comprehensive search was performed in China National knowledge Infrastructure (CNKI), Wanfang Data, Web of Science and PubMed database to identify the well qualified literature focusing on the relationship between PSA occurrence and serum inflammatory biomarkers, and a total of 13 studies were retrieved. Analysis indicates a certain association between PSA occurrence and serum inflammatory biomarkers, and denotes that the elevation of inflammatory biomarkers may be a trigger for the disease occurrence and its progression, but the specific mechanism underlying this relationship requires further study. [ABSTRACT FROM AUTHOR]

The improvement of medical quality in stroke with the goal of facilitating the translation of guideline recommendations into clinical practice, has become a priority prevention and control strategy to address the global burden of stroke. This review introduces representative studies of multi-faceted quality improvement based on the concept of learning health system, strategies continuously improving the timeliness of reperfusion therapy for stroke, and applications of mobile health and telemedicine assisting in the quality management of the whole process of stroke in the context of the digital era. This paper summarizes the current advances and potential directions in the field of stroke medical quality improvement, in order to provide references for the design and implementation of medical quality improvement programs and the development of monitoring and improvement system of stroke medical quality in China. [ABSTRACT FROM AUTHOR]

Cerebrovascular clinicians from different countries all over the world made great progress in the diagnosis and treatment of cerebral vascular diseases in recent years. Numerous high-quality clinical studies cover multiple fields and hotspots of cerebral vascular disease, such as thrombectomy/thrombolysis in the acute phase of ischemic stroke, intervention for atrial fibrillation, blood pressure management and other acute phase intervention measures, providing solid and reliable evidence-based medical evidence for clinical diagnosis and treatment in cerebral vascular disease, and promoting the reduction of cerebral vascular disease burden. This paper reviews the important clinical research progress in the field of cerebral vascular disease in 2023, helping readers better understand the advantages and great significance of these clinical studies, and looking forward to more and better cerebral vascular disease clinical studies in the future. [ABSTRACT FROM AUTHOR]