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The multi terminal flexible interconnection equipment with cascaded full bridge and dual active bridge structure could connect AC power grid and multiple DC power grid, and instantaneous power differences in different DC power grids and sub module faults could lead to unbalance grid current and DC capacitor voltage distribution. For the three-phase star interconnection structure, this paper adopted the control strategy of injecting zero sequence voltage to meet the different power requirements, derived the specific zero sequence voltage component expression, and quantitatively analyzed the limitation range of injected zero sequence voltage. Finally, a simulation experimental platform was built to verify the effectiveness of the method. The simulation results indicated that injecting zero sequence voltage on the basis of the normal control architecture can allocate the power between phases to ensure grid current balance, reduce imbalance from 6% to 1%,and maintain the even distribution of DC capacitor voltage. [ABSTRACT FROM AUTHOR]

The elasticity of the distribution network indicates the ability of the system to restore its original state after interference, and the frequent occurrence of natural disasters requires that the distribution network can not only operate reliably under normal conditions, and but also maintain the necessary capabilities for extreme disasters. Accordingly, a reliability evaluation method of elastic distribution network based on fault incidence matrix(FIM)was proposed in this paper. With FIM, the explicit analytical calculation of the reliability, elasticity and power supply capacity of the distribution system can be achieved by using simplified matrix algebra and Boolean operation, which saves the repetitive search work of fault enumeration in the evaluation process, and the calculation time, and can be applied to the complex structure of the distribution network and easy to expand. The final results show that the calculation time of the proposed method is only about 0.055s, which is reduced by 87% and 75% respectively compared with that of the fault diffusion algorithm and the block algorithm. [ABSTRACT FROM AUTHOR]

Livelihood capital is the core element of sustainable livelihood development for rural households. Based on the survey data of 615 growers in the main rubber-producing areas of Hainan and Yunnan province, this paper constructs an evaluation system of rubber growers' livelihood capital within the sustainable livelihood analysis framework and calculates key indicators, such as farmers' livelihood capital index, livelihood activity diversity index, and household income diversity index. The multiple regression model and the mediating effect model are used to explore the influence mechanism of livelihood capital on the sustainable livelihood of rural households. The following three conclusions are drawn: (1) The accumulation of livelihood capital of rural households is conducive to enriching the structure of household livelihood activities and income sources, especially the accumulation of financial capital, which is more likely to improve the diversity of household livelihood activities. Regional differences exist in the impact of livelihood capital structures on rural household livelihood outcomes. Natural capital endowment has a significant effect on the income diversification level in Hainan, but there may be a "curse" effect in Yunnan. (2) Geographical characteristics, production decisions, and farming household characteristics significantly impact sustainable livelihoods. The altitude of the village and the distance from the county seat pose certain challenges for farmers in diversifying their livelihoods. Although the law of rubber tapping production may weaken farmers' production and business activities, it can better stabilize farmers' incomes owing to its strong flexibility in labor arrangements, which may be beneficial for diversifying livelihoods; however, it does not necessarily lead to diversified incomes. While the characteristics of poor households can help rural households gain policy support, building capacity is the key to achieving a sustainable livelihood. (3) There are intermediary effects of livelihood capital on livelihood activities and household income, but the mechanisms of action are different. For the diversity of farmers' livelihoods, 52.70% of the catalytic effect of livelihood capital is achieved by improving the ability to integrate livelihood capital. Optimizing household employment strategies contributed to the promotion of livelihood capital on the income diversification index, with a mediating effect of 30.52%. The main contribution of this study is to clarify how livelihood capital can achieve the goal of diversifying household livelihood activities and income by coordinating livelihood capacity and employment strategies. Therefore, to enhance the comprehensive livelihood capacity of rural households, the coordination capacity of livelihood capital, livelihood capacity building should be enhanced, and employment information channels should be expanded. [ABSTRACT FROM AUTHOR]

Built environments have complex effects on the public's physical and mental health. Revealing the mechanisms and pathways through which the urban built environment influences public health can provide a basis for optimizing built environments. This helps avoid issues, such as environmental pollution, lack of social interaction, and insufficient physical activity, ultimately contributing to the enhancement of public health. Western academia has a more established foundation for research, whereas domestic endeavors are currently in the exploratory phase. A comparative analysis of relevant domestic and international studies can help elucidate the developmental trajectory of research in this field, identify common issues and characteristics, and guide the direction for advancing domestic research. Therefore, based on the Web of Science and China National Knowledge Infrastructure databases, this study systematically reviewed 658 English and Chinese studies published from 2000 to 2022 in the fields of urban and rural planning, geographic sciences, health medicine, and environmental psychology, focusing on the impact of the built environment on public health. Utilizing "Citespace" software, this study conducted a quantitative analysis and systematic review of the theoretical framework, study topics, and emerging trends in the research. The findings revealed disparities between Western and Chinese academies in terms of theoretical innovation, study groups, and research content. Specifically, international studies have pioneered theoretical perspectives, such as social welfare and environmental justice. Guided by these theories, researchers have explored the mechanisms through which the built environment affects public health in diverse population groups. Although domestic studies exhibit a relative lack of theoretical innovation, their primary focus has been the introduction and empirical application of Western theories in the Chinese context. These studies often concentrate on the transmission paths of the impacts on the older and women groups through static empirical evidence, lacking dynamism in their approaches. Furthermore, drawing upon the previously stated theoretical underpinnings, methodological approach, and research content, this paper summarized the analytical framework of "Built Environment Elements, Mediated Impacts, and Public Health." It meticulously examined the differential effects of three spatial elements--green space, land use, and road traffic--on public health. This study provides a detailed analysis of the mechanisms involved, highlighting the ecological and psychological benefits arising from exposure to and interactions with green spaces. It also analyzes how judiciously designed and compact land use patterns shape travel preferences, reduce travel distances, mitigate reliance on motor vehicles, and enhance the frequency of individual activities. Furthermore, the study outlines the ramifications for optimizing the road network system and transitioning travel modes to ameliorate traffic pollution, alleviate traffic pressure, and mitigate pedestrian injuries, among other variables. The purpose of this study was to systematically comprehend the current status and disparities in domestic and international research concerning the impact of the built environment on public health and to explore a series of health issues triggered by the built environment from the perspective of urban planning, with the hope of promoting health geography in China, offering guidance for future academic directions, and prompting local management authorities to formulate precision policies addressing public health challenges. [ABSTRACT FROM AUTHOR]

The safety issue of animal food has received widespread public attention due to increased reports of problematic foods. Once veterinary drugs are overused or abused in the process of animal husbandry, drug residues will bring serious harm to human health. Common residue detection methods have the disadvantages of high cost, slow speed and low efficiency, which usually requires professional personnel to operate, and the traditional physical and chemical methods can't meet the needs of food quality testing. As a result, the research and development of rapid and efficient detection methods for veterinary drug residues is necessary. In recent years, surface-enhanced Raman spectroscopy (SERS) has been widely used in many fields such as authenticity identification, illegal additives detection, agricultural and veterinary residues, etc, and has a broader development prospect in the field of food testing due to its advantages of fast detection and nondestructive. SERS is different from other detection methods in that it can rapidly identify target analytes through signal amplification and highly sensitive fingerprint spectroscopy for qualitative or semi-quantitative analysis. This paper mainly introduces the research and application of Raman spectroscopy and SERS in the detection of veterinary drug residues in foods of animal origin, focusing on the advantages of SERS, the pre-treatment of food samples, and the related research on the detection of a variety of veterinary drugs by SERS combined with other techniques, and proposing the challenges faced by SERS in practical monitoring. [ABSTRACT FROM AUTHOR]

The high performance liquid chromatographic (HPLC) fingerprints of TongFu XieXia Granules (TFXXG) are established, and the contents of Emodin, Chrysophanic acid, Rhein, Aloeemodin, Physcion, Magnolol and Honokiol are simultaneously determined. The separation is performed on a Waters Symmetry C18 column (2. 1 mm × 150 mm, 3. 5 µm) with a gradient elution of 0. 1% aqueous phosphoric acid (A) and methanol (B) as the mobile phases, at a flow rate of 0. 4 mL/min, with the column temperature at 30 ℃, the detection wavelength at 254 nm, and the injection volume of 10 µL. The fingerprints of 10 batches of TFXXG are established, and the similarity is calculated by using the “Evaluation system for similarity of chromatographic fingerprints of traditional Chinese medicines”(2012 version); the contents of Emodin, Chrysophanic acid, Rhein, Aloeemodin, Physcion, Magnolol and Honokiol are determined. The results show that a total of 25 common peaks is identified in the 10 batches of TFXXG, and the similarities are all above 0. 950; a total of 12 common peaks are identified, which are Sinapine thiocyanate, Caffeic acid, Echinacoside, Naringin, Neohesperidin, Aloeemodin, Rhein, Magnolol, Honokiol, Emodin, Chrysophanic acid and Physcion, respectively. The contents of Aloeemodin, Rhein, Magnolol, Honokiol, Emodin, Chrysophanic acid and Physcion are 0. 1244~0. 1304, 0. 4271~0. 4387, 3. 0479~3. 0853, 1. 2910~1. 3039, 0. 2427~0. 2523, 0. 7718~0. 7897 and 0. 5085~0. 5249 mg/g, respectively. The fingerprints and quantitative analytical methods constructed in this paper are reproducible and operable, and can be used to control the quality of TFXXG. [ABSTRACT FROM AUTHOR]

Organophosphorus pesticides (OPs), as one of the most toxic pesticides, have the characteristics of wide use, large usage and great harm to human health. With people's longing and continuous pursuit of a healthy life, it is particularly urgent and important to build accurate, sensitive, convenient and fast OPs residual analysis and detection sensor. Because of the unique optical, electrochemical and biological properties of nanomaterials, OPs detection sensors based on nanomaterials have the advantages of sensitivity, high efficiency and economy. In this paper, the domestic and foreign sensors for detecting OPs residues based on rare earth doped up conversion nanomaterials, metal nanomaterials, metal oxide nanomaterials, carbon nanomaterials and quantum dot nanomaterials from 2015 to 2023 are reviewed, providing ideas and basis for the subsequent development of nanomaterial-based OPs multi residue detection sensors. [ABSTRACT FROM AUTHOR]

It is of great significance to select appropriate supports to support Pt nanoparticles for the preparation of efficient phenol hydrogenation catalysts. In this paper, Pt nanoparticles confined into the inner wall of titanium oxide nanotubes were prepared by template assisted method of atomic layer deposition technology. The specific preparation method was to use carbon nanofibers as templates, successively depositing Pt nanoparticles and thick titanium oxide shell on the templates surface. Then, the templates were removed by high-temperature sintering, through which Pt nanoparticles confined into the inner wall of titanium oxide nanotubes can be obtained. The particle size of the Pt nanoparticles ranged from 2. 0 to 3. 2 nm at a sintering temperature of 500 ℃, with an average size of 2. 6 nm. Transmission electron microscopy results confirmed that Pt nanoparticles with highly uniform size were evenly dispersed and embedded into the inner wall of the hollow channel of titanium oxide nanotubes. The results of the catalytic performance of phenol hydrogenation show that the small-size Pt nanoparticles have the best phenol hydrogenation activity, with a Turnover Frequency (TOF) value of 482. 1 h−1 at a sintering temperature of 500 ℃ . In addition, compared with the conventional Pt nanoparticles with the same size supported on the outer wall of titanium oxide nanotubes, it is found that the confined catalyst shows better catalytic activity. Furthermore, due to the protective effect of titanium oxide nanotubes, it can effectively prevent the aggregation and falling off of Pt nanoparticles in the reaction process. After the reaction, the Pt content only decreased by 4. 52%, and there were no significant changes in the morphology observed, thus the confined catalyst showing excellent catalytic stability compared with the supported catalyst. [ABSTRACT FROM AUTHOR]

Objective Tumor is a major public health problem harmful to people's health. Cell copper death provides a new idea for the basic research of tumor. This paper reviews the latest progress of cell copper death in the field of tumor prevention and treatment. Methods The literatures related to copper death in tumor prevention and treatment were summarized, and the research status of copper death related genes in different types of tumors was reviewed. Results Ferredoxin 1 (FDXl), lipoic acid synthase (LIAS), dihydro lipocyte answers (DLAT), and dihydro lipoamide S-succinyl transferase (DLST) were the key regulatory genes of copper death, which were abnormally expressed in lung cancer, hepatocellular carcinoma, and breast cancer. Among them, the low expression of FDXl in tumor patients was related to the poor prognosis of the disease, while the overall survival time of cancer patients with high expression of DLA T and DLST genes was decreased. In addition, targeting copper death protein and promoting cell copper death inhibited the proliferation of cancer cells in vivo and in vitro. Conclusion Several genes related to copper death, such as FDXl, LIAS, DLAT, and DLST, are abnormally expressed in cancer patients and are related to the occurrence, development, metastasis, and prognosis of the tumor. Targeted promotion of cell copper death and inhibition of cancer cell proliferation provide a new direction for future basic research in the field of tumor, which has public health significance for tumor prevention and treatment. [ABSTRACT FROM AUTHOR]

The International Codex Alimentarius Commission (CAC) issued a new version of the general rules on food hygiene in 2020, which revised and improved the structure, definition and technical contents of the standard, clarified the important role of good hygiene practices in food safety management, and emphasized the advantages of Hazard Analysis and Critical Control Point (HACCPL) in dealing with more complex food safety issues. It also added the latest achievements of standardization research in the field of food safety in recent years, such as allergen control and food safety culture. By comparing the new version of the standard with the 2003 edition of general principles of food hygiene, this paper expounds and analyzes the main changes of the new version of the standard in detail, so as to provide reference for the formulation and implementation of food-related standards in China. [ABSTRACT FROM AUTHOR]

N6 -methyladenosine (m6 A) modification is one of the most abundant epitranscriptomic modifications in eukaryotic mRNA, with dynamic and reversible properties. This modification process is coordinated by methyltransferases, demethylases, and related m6 A binding proteins, which in turn affect mRNA metabolism and function. Increasing evidence has indicated that the m6 A RNA modification plays an important role in the occurrence and development of atherosclerosis (As) and other related diseases. This paper provide a comprehensive review of the relationship between m6 A RNA modification and As. The entire manuscript summarizes the m6 A RNA modification mechanism and its roles in Asrelated cells including endothelial cells, macrophages, and smooth muscle cells, and discusses the association of m6 A RNA modification with risk factors of As such as high-fat diet, ischemia/hypoxia, oscillatory stress, and hypertension. Finally, this review summarizes researches on drug intervention targeting m6 A RNA methylation to mitigate As. These studies provide important references for exploring new targets for early diagnosis and treatment of As. [ABSTRACT FROM AUTHOR]

Currently, reperfusion therapy targeting the ischemic penumbra is the preferred treatment for acute ischemic stroke. The continuous advancements in neuroimaging techniques for the ischemic penumbra have provided more evidence for reperfusion therapy based on tissue window. This review summarized the significant progress of the ischemic penumbra over the past 50 years, focused on the current neuroimaging assessment methods of ischemic penumbra, including the widely used ischemic hypoperfusion-infarct core or clinical symptom-infarct core mismatch and emerging techniques such as multiphase CTA, ASL, etc. Additionally, this paper compared 5 mainstream automatic post-processing software of image in the market, aiming to provide reference for clinical reperfusion diagnosis and treatment. [ABSTRACT FROM AUTHOR]

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary cerebral small vessel disease caused by mutations in the NOTCH3 gene. The main vascular pathological changes in CADASIL are intracranial small arteries, with rare reports of involvement in the cerebral cortex and intracranial large/middle arteries. There is currently a lack of specific treatment for CADASIL. This paper reported a case of CADASIL patient who successfully received endovascular treatment for acute occlusion of middle cerebral artery, and discussed the literature with the aim of raising clinical awareness of the potential involvement of CADASIL in the cerebral cortex and intracranial large/middle arteries. [ABSTRACT FROM AUTHOR]

Fibroblast growth factor 23 (FGF23) -Klotho endocrine axis is involved in phosphate metabolism, and is closely related to the pathogenesis of stroke. FGF23 and Klotho levels are associated with the incidence and prognosis of stroke. The FGF23-Klotho endocrine axis is involved in the regulation of vascular inflammation and may be involved in the pathological process of stroke risk factors such as hypertension, insulin resistance, lipid metabolism and obesity. In this paper, the influence and mechanism of FGF23-Klotho endocrine axis on stroke were reviewed in order to bring new ideas for clinical treatment and prevention of stroke. [ABSTRACT FROM AUTHOR]

Objective To analyze the current research status, hotspots, and frontier fields of perivascular spaces from 2013 to 2023 based on bibliometric analysis. Methods The related English article of perivascular spaces was retrieved in the Web of Science Core Collection from January 1, 2013 to June 19, 2023. CiteSpace V6.3.R1 software was used to analyze the cooperation network among the publishing countries, institutions and authors; the co-citation network of reference, first author of reference and journals; the co-occurrence network of keywords, burst analysis of keywords and reference co-citation. VOSviewer 1.6.15 software was used for keywords cluster analysis. Results A total of 1549 papers were included. The annual publications from 2013 to 2023 showed an overall increasing trend. The United States ranked the first and China ranked the second. The top three prolific institutions were Harvard University, Massachusetts General Hospital and University of Edinburgh. Cooperative network analysis showed that the cooperation between countries was close and domestic institutions collaborated less with other institutions. Wardlaw Joanna M from University of Edinburgh ranked the first in publications. The top ten keywords in co-occurrence network were small vessel disease, enlarged perivascular spaces, MRI, brain, Virchow-Robin spaces, Alzheimer’s disease, dementia, risk, stroke and glymphatic system. Cluster analysis of keywords showed that cerebral small vessel disease, dementia and MRI were current hotspots, and glymphatic system was a new research direction. Burst analysis of keywords suggested diffusion imaging has got much attention since 2021. Conclusions The research on perivascular spaces has increased during the recent 10 years. Cerebral small vessel disease was the main hotspot and glymphatic system was a new direction. Diffusion tensor imaging was a frontier field. [ABSTRACT FROM AUTHOR]

Cerebral small vessel disease (CSVD) is a series of clinical, imaging and pathological syndrome caused by various causes affecting the small blood vessels in the brain. There is no unified diagnostic standard in the world for CSVD, and the symptoms are mild. Therefore, based on neuroimaging findings, it can be divided into recent small subcortical infarct, lacune of presumed vascular origin, white matter hyperintensity of presumed vascular origin, perivascular space, cerebral microbleed, cortical superficial siderosis, and brain atrophy. Evidence suggests that CSVD may be associated with a variety of neuropsychological manifestations. However, the relationship between neuropsychological symptoms and the occurrence and development of CSVD is not clear. In this paper, the research progress of the relationship between apathy, fatigue, anxiety, depression and psychological stress and the imaging of CSVD was reviewed. [ABSTRACT FROM AUTHOR]

Cerebral small vessel disease (CSVD) is a group of clinical, imaging and pathological syndromes mainly involving intracranial small vessels. The onset of CSVD is occult. It is closely related to stroke, cognitive decline, affective disorders, gait abnormalities and urinary and fecal incontinence. It brings heavy disease burden and economic burden to the family and society. However, the true pathogenesis of CSVD is still unclear, and the clinical diagnostic criteria are not uniform, which makes clinical diagnosis and treatment and experimental research face major challenges. The purpose of this paper is to discuss the progress and limitations of the etiology, pathogenesis, clinical diagnosis and treatment of CSVD, and to look forward to the possible clinical research direction of CSVD in the future. [ABSTRACT FROM AUTHOR]

Metabolomics is a novel emerging technology recently applied in management of severe diseases and trauma, and has been widely used in gene analysis of disease metabolic disorders, clinical biomarker screening and disease diagnosis. This review comprehensively summarizes the latest research progress of the metabolomics in severe trauma and burns recently like traumatic brain injury(TBI), traumatic hemorrhagic shock, severe burns and so on. The paper elaborates the metabolomic technology which can quickly reflect the real-time metabolic changes of severely injured patients at different stages after injury, and uncovers new clinical biomarkers and potential drug targets of the patients with severe injuries thus improves the diagnosis and treatment strategies. Finally, we look forward to the current metabolomics research projects and tackling challenges on the burn-blast combined injuries, and the simultaneous development of multi-omics technology as well as artificial intelligence algorithms, which promotes the development of precision medicine. [ABSTRACT FROM AUTHOR]

Correct facial analysis is the first step to achieve good results in any facial plastic surgery or facial rejuvenation surgery/procedure・ Assessing the corresponding anatomic area of facial aging through facial analysis and precisely designing the surgical plan can achieve and standardize a scientific diagnosis and procedure of the facial rejuvenation・ This paper introduces the facial analytical methods, scientifically expounds the anatomical structure and physiological characteristics of aging in each region, and analyzes the effect of application of facial analytical method in facial rejuvenation, in order to provide reference for plastic surgeons to design facial rejuvenation plan. [ABSTRACT FROM AUTHOR]

Malassezia is a group of resident fungi on the skin, which can cause diseases under certain conditions・ Among the multiple complicated factors involved in the pathogenesis, secreted proteases of Malassezia are the key factors・ Secreted proteases are enzymes capable of hydrolyzing protein peptide bonds, which has special significance in the skin environment enriched in proteins and lipids・ So far, 21 species of Malassezia have been identified・ Most studies are related to identification and naming, protease activity and pathogenicity of secreted proteases secreted by Malassezia furfur Malassezia globosa, Malassezia pachydermatis and Malassezia restricta. This paper aims to review the research progress on the secreted proteases of Malassezia furfur Malassezia globose, Malassezia pachydermatis and Malassezia restricta. [ABSTRACT FROM AUTHOR]

Pepper originated in South America and was introduced to China in the 16th century. With high nutritional value, pepper has an important role in health care, beauty, food, medicine, violence and other industries. It becomes one of the most important vegetable crops in China. With the gradual increase of cultivation area pepper ranks the top among vegetable crops in China in this aspect. In the process of pepper production, it inevitably suffers from various diseases, causing great losses to production. It is the most economical and effective measure to control diseases through selecting disease-resistant varieties, although the chemical control methods and agricultural control measures can reduce the harm to a certain extent. With the development of molecular biology, the combination of molecular breeding and conventional breeding methods for disease resistance is a direction of future breakthroughs. In recent years, great progress has been made in the molecular breeding of pepper disease resistance, especially, the molecular mechanism of disease resistance. Molecular breeding mainly includes two parts: one is marker-assisted breeding, and the other is creating disease-resistant breeding materials by means of genetic engineering. In marker-assisted breeding, molecular markers must be found first. Molecular markers are divided into gene markers, markers obtained by linkage analysis in segregation populations, and markers gotten by association analysis through sequencing of a large number of materials. The premise of genetic engineering is to isolate and obtain disease resistance genes, and then introduce them into pepper breeding materials with good economic traits, or mutate negatively regulated genes through gene editing technology or gene silencing technology to improve disease resistance of plants. In this paper, molecular markers and marker-assisted selection, molecular mechanism of disease resistance and disease-resistant germplasm (resistance to virus, bacterial wilt and Phytophthora capsici) obtained by genetic engineering technology are comprehensively introduced, and the development trend and research focus in the future are prospected. [ABSTRACT FROM AUTHOR]

Peanut is an important oil crop in China. Peanut seed itself and its processed products can produce a unique aroma, and its aroma quality is one of the most important indicators to determine the market. Peanut seed can produce different aroma substances through different processing methods, and peanut aroma is composed of a variety of volatile substances, including pyrazines, pyrroles, furans, pyridine, aldehydes, ketones, alcohols, hydrocarbons, aromatic compounds and other compounds, and different volatile substances have different aromas. There are three main sources of aroma substances in peanut: Maillard reaction, fat oxidation and thermal degradation reaction, and degradation reaction of amino and sugars. At present, there are few studies on the biosynthetic pathways of aroma substances in peanut. With the development of science and technology, more and more volatile compounds have been identified. At present, peanut aroma is mainly extracted by headspace solid phase microextraction and detected by gas chromatography-mass spectrometry. The formation of peanut aroma is mainly affected by factors such as genotype, processing mode and processing time, seed water content and other factors. A large number of literatures have shown that cultivation modes affect the accumulation of aroma substances in rice, but there is no report on the effect of different cultivation mode on the accumulation of aroma substances in peanut. At the same time, the use of volatile compounds can also inhibit the pollution of peanut aflatoxin, reduce the economic loss of peanuts, and use volatile substances to distinguish different kinds of vegetable oil. Taking peanut seed as the object, this paper reviwed the composition analysis of peanut aroma substances, the classification of peanut aroma substances, the extraction and analysis methods of peanut aroma substances, the factors affecting the formation of peanut aroma substances and the influence of Aspergillus fl avus pollution by peanut aroma substances, providing theoretical basis for the study on the formation of peanut aroma quality. [ABSTRACT FROM AUTHOR]

Objective To discuss the risk factors of imported food through the multi 一 dimensional comparative analysis of the food information published by the General Administration of Customs and to provide data reference for supervisors, and to improve the supervision of imported food. Methods This paper mainly collected and summarized the 48 periods of non 一 permitted entry food data released by the Import and Export Food Safety Bureau of the General Administration of Customs during 2019 一 2022 and made a comparative analysis of the sources of non - permitted entry food, food production enterprises, product types, non 一 permitted entry facts and other dimensions. Results From 2019 一 2022, there were a total of 9 506 batches of food that were not allowed to enter the country, and the food that was not allowed to enter the country came from 112 countries and regions, with the highest proportion of food batches from Japan. The food came from 3 941 production enterprises, where 11 countries or regions holding non 一 permitted entry food production enterprises, accounting for more than 50% of the total number of enterprises. According to the HS code, there were six categories and 21 chapters of non 一 permitted entry products, and the main non 一 permitted entry foods were HS03, 21, 19 and 22 products, more than 60% of the total unqualified. According to the analysis of the causes of nonconformity, there were 15 kinds, and the top 6 nonconformity causes accounted for 86% of the total nonconformity batches. There was a total of 268 types of unqualified items related to quality and safety, totaling 3 469 items. Conclusion The overall number of batches of unauthorized imported food during the period of 2019 一 2022 is a rising and then falling trend, and the unauthorized imported food is more concentrated in the countries of origin, manufacturers, categories of unauthorized food, reasons for failure, and quality 一 related unqualified items. The multi 一 dimensional comparative analysis provides data reference for regulators and consumers and helps the government to improve the regulation of imported food. [ABSTRACT FROM AUTHOR]

Objective To explore the relationship between Internet use and cognitive function in the elderly. Methods Based on the data of China Family Panel Survey (CFPS) in 2020, the IADL scale and the mobile center self 一 rating depression scale were used to measure the disability status and depression status of the elderly. Two 一 column correlation analysis was used to analyze the correlation. This paper constructed a multiple mediating effect model to study the mediating path of the impact of Internet use on the cognitive function of the elderly. Results After controlling for age, gender, marital status, and intergenerational support, the regression results showed that the use of the network had a significant direct impact on the cognitive function of the elderly (仔 =0. 688, £ 二 7. 36, P < 0. 001), and depression and disability significantly affected the cognitive function of the elderly (/3 = - 0. 018,/二 - 2. 696, P <0. 05;/3 = - 0. 114, t - - 4. 83, P < 0. 001). The results of mediating effect analysis showed that the simple mediating effects of depression and disability between Internet use and cognitive function of the elderly were 0. 044 (95% C/: 0. 011 3 - 0. 083 4) and 0. 040 (95% CIz 0. 015 8 - 0. 064 2), respectively, and the chain mediating effect was 0. 006 (95% C/：0. 000 4-0. 013 2). Conclusion Depression and disability status have a mediating effect between whether or not to use the network and the cognitive function of the elderly, and depression and disability have a chain mediating effect in whether or not to use the network to affect the cognitive function of the elderly. With the popularization of the Internet, we should promote the use of the Internet in the elderly, and pay attention to the physical and mental health of the elderly, so as to protect the cognitive function of the elderly and delay or prevent the occurrence of cognitive impairment in the elderly. [ABSTRACT FROM AUTHOR]

The self 一 management of patients with multiple chronic conditions has more complex characteristics and needs than those of single chronic diseases and plays a central role in healthy disease regression. This paper focuses on the characteristics, current status, barriers and challenges of self 一 management in patients with multiple chronic conditions, and suggests that self 一 management of multiple chronic conditions should be viewed from a dynamic and developmental perspective. When providing self - management support to patients, it should be based on their complex self 一 management needs, identifying specific barriers to the self - management process, establishing self 一 management links between multiple chronic conditions, and developing personalised self - management support content and methods based on patients' preferences, goals, and available resources, to improve their self 一 management abilities and health outcomes. [ABSTRACT FROM AUTHOR]

In view of the situation that the emergency work of the distribution room is facing severe challenges due to frequent disasters, this paper conducts a study on the power disaster accident scenario inference technology of power distribution room. Based on the analysis of the suddenness and variability of the power distribution room disasters, the uncertainty and complexity of the evolution path, the "scenario response" analysis method is used to analyze the components of the power distribution mom accidents and their relationships, and the scenario rehearsal model of the power distribution room disasters is constructed based on the dynamic Bayesian network. The effect evaluation of drill is carried out based on the principle of timeliness. A 6 kV power distribution room fire accident in a mining company is conducted case analysis. The results show that the simulation results are consistent with the actual disaster development situation, which indicates the feasibility of the power distribution room disaster scenario model. [ABSTRACT FROM AUTHOR]

The form and available state of elements are important indexes to evaluate the activity of elements. Research on the relationship between the available state and form of selenium (Se) and zinc (Zn) in farmland soil is an important basis for accurate land quality evaluation. In this paper, the available states and different forms of Se and Zn in the soil of high Se background area in Luoyang farmland were studied. The results show that the available Se in wheat soil can be replaced by the sum of water-soluble state, ion state and carbonate state. The available Se in the soil of corn, millet, sesame, peanut and sweet potato can be replaced by the sum of water-soluble state and ion state. Available Zn can be represented by the sum of water-soluble, ionic and carbonate states. The active Zn in the farmland soil developed in the basalt area was low and similar to the water-soluble Zn. The available state and forms of Se and Zn in farmland soil were mainly affected by total amount, but also by cultivated crops, pH and organic matter. It is necessary to consider agricultural planting, pH and organic matter to evaluate the availability of Se and Zn by using the form instead of the available state in farmland soil. [ABSTRACT FROM AUTHOR]

Strabismus, misalignment of the eyes arising from central nervous system dysregulation and extraocular muscles imbalance, commonly manifests in childhood, leading to amblyopia, binocular vision dysfunction, torticollis and other developmental and psychological disorders. This exerts a negative impact on individuals, families and society. Timely diagnosis and intervention are crucial to prevent permanent damage to vision and stereopsis. Presently, strabismus diagnosis is reliant on the ophthalmologists′ evaluations which results in a lack of efficiency and coverage. However, routine school screening proves inadequate in assessing strabismus degree with low accuracy. Therefore, how to improve the efficiency of strabismus screening is an issue of great importance. This paper delves into the present landscape of strabismus diagnosis and treatment, considering both local and global research advancements. It focuses on the evolution of artificial intelligence technology, illuminating the utilization of artificial intelligence models and algorithms in strabismus. By pinpointing and exploring their strengths and limitations, it offers valuable insights, paving the way for future investigations into artificial intelligence-assisted strabismus diagnosis and treatment. [ABSTRACT FROM AUTHOR]

With rapid urbanization, the formation of a governance model for spatial stock has become challenging in building a modern governance system. The process of "domainization" in spatial stock constantly affects the biopolitics of different groups during marketization. This paper introduces the perspective of Foucault's biopolitics based on the domain theory and constructs a domain politics framework indicating a tripartite coupling and interaction among social capital, spatial relations, and life politics. Through semi-structured interviews with, and questionnaires administered to, ordinary workers, middle managers, and top directors, we investigate the changing patterns of workers' biopolitics in the "Territorialization" of grassroots governance. The findings show that the "domainization" process relative to industrial parks has gone through three periods: first, when the state strongly shaped the construction of order and the state economy; second, when the government retreated and capital advanced on a large scale; and third, when there was tripartite competition between the government, workers, and capital. The structures of social capital, spatial relations, and biopolitics experienced a dramatic shift during the succession process of the three periods. The economic attributes of industrial parks shape the various spatial relationships of life and production among workers, middle-level cadres, and top directors, causing differences in the accumulation of social capital for the different classes. The compartmentalization of the spatial field has resulted in a reduction in workers' public activities and the weakening of social capital accumulation. The life politics of workers shifted from self-directed ownership of the A town mechanical farm to early economic dependency, then to full dependency on the park. First, this study bridges the gap in the study of "domainization" in production fields and provides a geo-theoretical perspective for understanding how workers' biopolitics is driven by this process in the context of the transformation in economic production relations. Second, the phenomenon of authority transfer in "domainization" is proposed based on the theory of state-society relations. A detailed explanation of the occurrence of semi-centralized governance in modern society is provided herein. Finally, study findings provide theoretical support and case studies on how sphere politics in grassroots governance affects spatial production relations, achieving integration of the disciplines of politics and geography. [ABSTRACT FROM AUTHOR]

Amino acids, as the fundamental components of proteins, contain both acidic and basic groups (amino and carboxyl groups) in their molecular structure, and amino acid ionic liquids with amino acids as anions or cations can be conveniently formulated. Amino acid ionic liquids with the advantages of high solubility, low melting point, and high thermal stability. These liquids find applications as carbon precursors, solvents, catalysts, and adsorbents in various fields such as energy storage, biomass utilization, and carbon capture. This paper provides an overview of the research progress made in the utilization of amino acid ionic liquids in supercapacitor electrode materials, biomass conversion, and carbon dioxide separation and capture in the past seven years. Specifically, it focuses on the advancements in utilizing amino acid ionic liquids as precursors in supercapacitor carbon electrode materials. Furthermore, it highlights the potential applications and future development prospects of amino acid ionic liquids. [ABSTRACT FROM AUTHOR]

Near-infrared phosphor-converted light-emitting diodes (NIR pc-LEDs) are expected to be the next-generation NIR light sources, with the advantages of small size, broad bandwidth, and easy tuning of emission peaks. The key for NIR pc-LEDs is to develop highly efficient broadband NIR phosphors that can be effectively excited by blue light. Cr3+ -activated NIR phosphors have been widely studied, and this paper reviews the development of Cr3+ -doped NIR phosphors peaked at 800~900 nm. Based on phosphates, pyroxenes, and other systems, the relationships between the structure and the emission peak and bandwidth are summarized. Furthermore, to enhance the NIR performance, strategies of synthesis technology optimization, components design, and co-doping sensitizers are discussed in detail. [ABSTRACT FROM AUTHOR]

In order to further improve the ability of medical institutions to deal with mass and epidemic diseases, clinical workers need to have strong awareness of disease early screening and prevention and control, as well as the ability of monitoring, early warning, and emergency management. The underlying issue is the need to constantly strengthen clinical medical students' knowledge reserve and practical ability of preventive medicine. Especially in the process of medical education, how to strengthen clinical medical students' ability to master the basic knowledge and skills of preventive medicine, to be familiar with the management of mass and major epidemic diseases, and to establish the concept of prevention and treatment of acute and chronic diseases are urgent problems to be solved. This paper discussed in-depth the problems and measures related to the cultivation of disease prevention and control mindset and practical ability of clinical medical talents, so as to provide an important reference for improving the training mode of comprehensive clinical medical talents and the formulation of related policies. [ABSTRACT FROM AUTHOR]

The National Conference on Propaganda, Ideological and Cultural Work was held in Beijing on October 7th and 8th, 2023. The conference conveyed the important instructions of General Secretary Xi Jinping on propaganda, ideological and cultural work, and officially proposed and systematically elaborated on Xi Jinping's cultural thought. This significant meeting, convened by the Party Central Committee in the new journey of national rejuvenation and strong nation-building, underscores the imperative to comprehend and implement the spirit of the conference. It emphasizes the profound study and implementation of Xi Jinping's cultural thought in all aspects and processes of cultural construction. Since the 18th National Congress of the Communist Party of China, the Party Central Committee, with ComradeXi Jinping at its core, has shown foresight and set directions, accurately grasping the trends of ideological and cultural exchanges worldwide and deep shifts in societal thoughts in China in the new era. From a strategic height of governing the country, the Committee has consistently prioritized propaganda, ideological, and cultural work, proposing a series of new ideas, viewpoints, and judgments around the guiding principles, objectives, responsibilities, and values of cultural construction in the new era, thereby forming Xi Jinping's Thought on Culture. This paper systematically discusses the background, core essence, and practical pathways of this innovative theory of the Party, aiming to provide references for advancing the construction of socialist culture with Chinese characteristics and building a modern civilization for the Chinese nation. The study posits that Xi Jinping's Thought on Culture represents a rich development of Marxist cultural perspective, marking a new height in the innovative development of Marxism in the context of Chinese modernization with its original theoretical contributions. It continues the Party's century-long cultural endeavors, innovating while adhering to the Party's hundred-year theory and practice in cultural work. The thought integrates numerous original cultural theories of the new era, achieving a systematic integration of the cultural deployments in this period. It stands as a milestone in the history of human civilization thought and the history of Chinese propaganda and ideological culture, serving as a distinct flag leading global developmental trends and advancing human civilization. Xi Jinping's Thought on Culture profoundly addresses fundamental questions in our national cultural construction in the new era, such as the principles to uphold, the path to follow, the objectives to achieve, and the strategies to employ. It elaborates on the Party's position, objectives, responsibilities, and practical requirements in propaganda, ideological, and cultural endeavors, thus anchoring the strategic focus of cultural construction in the new era. This provides an ideological weapon and action guide for better upholding and developing socialism with Chinese characteristics in the new era. To excel in propaganda, ideological, and cultural work in the new era, unwavering adherence to the scientific guidance of Xi Jinping's Thought on Culture is essential. Specifically, this involves maintaining the guiding role of Marxism in the ideological sphere, continually exploring new realms of Marxism; embracing the spirit of struggle to proactively advance propaganda, ideological, and cultural work in the new era; and steadfastly pursuing the path of cultural development under socialism with Chinese characteristics. Only by doing so can the common ideological foundation of the united struggle of the entire Party and people of all ethnicities nationwide be effectively consolidated. [ABSTRACT FROM AUTHOR]

To explore the forest structure and soilphysicochemical properties of the artificial mixed forest of Pinus elliottii and Liriodendron chinense in the rocky desertification area of Western Hunan, taking Pinus elliottii and Liriodendron chinense artificial coniferous and broad-leaved mixed forest in the rocky desertification area of Western Hunan as the research object, this paper provides a theoretical basis for vegetation restoration, plantation structure optimization, and soil improvement in this area. The stand structure and soil physicochemical properties of existing stands were analyzed using plant community analysis and field sampling detection methods. Winklemass 1.0 was used to calculate the spatial structure parameters of the stands, and three-dimensional discrete random variables were used to analyze the spatial distribution pattern of dominant species. The results were as follows:(1)A total of trees of 897 plants·hm-2 with diameter at breast height(DBH)≥ 2 cm in the stand, belonging to 15 families and 16 genera. The main forest layer was Pinus elliottii, with an average DBH of 32.3 cm and an important value of 44.2%; the secondary forest layer was the broad-leaved tree, with the majority of young and middle-aged trees. Cinnamomum camphora and Liriodendron chinense were the dominant species, with important values of 17.1% and 13.2%, respectively. In addition, there were many natural regeneration species at the disadvantaged ecological niche.(2)The horizontal distribution pattern of trees tended to be random(w̅=0.503); the overall trend of forest stands tended to transition towards mediocrity and disadvantage( Ū=0.505); the degree of interspecific isolation was relatively high(M̅=0.689), and the mixed forest was in good condition. Three-dimensional discrete random variables of spatial structure parameters showed that 87.3% of Pinus elliottii was dominant and sub-dominant, 41.7% of Liriodendron chinense was sub-dominant, 26.9% was moderate, 23.5% of Cinnamomum camphora was moderate, 56.8% was inferior and absolute inferior.(3)The pH value of forest soil tended to be neutral; compared with abandoned land, the bulk density, water capacity, porosity, organic carbon, total potassium, total nitrogen, and total phosphorus of the forest soil had significantly improved. However, the forest soil was still relatively barren, with local soil compaction and poor water retention ability. To sum up, after 43 years of growth of Pinus elliottii and Liriodendron chinense as pioneer species, the stand has a trend of succession to the uneven-aged forest and intensive mixed forest. However, the number of young and middle-aged broad-leaved trees in the forest is relatively large, and faults appear in the near mature forest. The elderly coniferous trees occupy the dominant ecological location. Needles need to be drawn to supplement the broad-leaved trees, interspersed to cultivate the broad-leaved trees, and selective felling the inferior trees, to promote the structural succession of the forest with mainly sunny broad-leaved trees, followed by mesophytic and shade-tolerant broad-leaved trees. The results of this study provide a theoretical basis for vegetation restoration, plantation structure optimization and soil improvement in the rocky desertification area of Western Hunan. [ABSTRACT FROM AUTHOR]

Atherosclerosis is the pathological basis of a variety of cardiovascular diseases, which are still the leading cause of human death worldwide. Ferroptosis is a kind of iron dependent non-apoptotic cell death mode, which is closely related to various physiological mechanisms. Recent studies have found that ferroptosis in macrophages plays an important role in the occurrence and development of atherosclerosis. Based on the imbalance of iron metabolism in macrophages, this paper reviews the correlation between ferroptosis in macrophages and atherosclerosis in terms of the interaction between ferroptosis in macrophages and lipid peroxidation, inflammation, oxidative stress, etc., in order to provide new ideas for the study of the pathogenesis of atherosclerosis. [ABSTRACT FROM AUTHOR]

Atherosclerosis is the main pathological basis for the occurrence and development of cardiovascular and cerebrovascular diseases. Macrophage efferocytosis deficiency exists in the formation of atherosclerosis. Defective efferocytosis leads to the accumulation of uncleared apoptotic cells and secondary necrosis, leading to characteristic formation of necrotic core and plaque instability in atherosclerosis. The complete process of efferocytosis includes recognition("find me")stage, phagocytosis("eat me")stage, and the post-processing reaction (digestion) stage. It has been reported that miRNA is involved in the regulation of key signal transduction and lipid homeostasis in atherosclerotic efferocytosis. This paper discussed the important role of efferocytosis in the process of atherosclerosis and the influence of efferocytosis defect on atherosclerosis. This review focuses on the regulatory effects of "eat me" and "don􀆳t eat me" signals of efferocytosis in the overall inflammation of atherosclerosis, and meanwhile the regulation of miRNA on lipid metabolism and inflammation regression in atherosclerosis, and the fine tuning of miRNA targeting macrophage efferocytosis in the process of atherosclerosis. [ABSTRACT FROM AUTHOR]

Heart failure is a fatal stage of end-stage cardiovascular disease, which brings a huge medical burden to the society because of its high mortality and re-hospitalisation rates. Intestinal microecology is the largest and most complex microecosystem of human body. It is inhabited by tens of thousands of microorganisms in human gastrointestinal tract. In recent years, with the deepening of the study of intestinal flora, more and more studies have found that the imbalance of intestinal microecology can cause changes of metabolites in heart failure patients, which is one of the key triggers for the development of heart failure, therefore, using the intestinal microbial homeostasis as a new entry point for the treatment of heart failure will be a hotspot in medical research. However, the theory of Chinese medicine, "the spleen is the guardian", covers the physiological functions of the spleen, such as the spleen􀆳s main function of transporting, spleen􀆳s main function of ascending and clearing, and its main function of hiding camping, etc., and the functions of intestinal flora and the "spleen is the guardian" are similar to a certain extent. Therefore, this paper starts from a holistic viewpoint and takes the theory of "spleen as the guardian" in Chinese medicine as an entry point to elaborate on the pathogenesis of intestinal microecological imbalance and heart failure, so as to provide a reference for Chinese medicine treatment or drug research. [ABSTRACT FROM AUTHOR]

Transcription factor EB(TFEB) is a member of the microphthalmia associated transcription factor family. It plays an important role in lipid metabolism and other biological processes by regulating the expression of autophagy and lysosomal related genes. The activity and cellular localization of TFEB can be regulated by posttranslational modifications of proteins. This paper discusses the mechanism of autophagy regulation by TFEB posttranslational modification, aiming to help understand the pathogenesis of related diseases caused by abnormal autophagy, and provides new ideas and feasible intervention targets for the prevention and treatment of corresponding diseases. [ABSTRACT FROM AUTHOR]

The key to the treatment of acute ischemic stroke is to quickly restore the blood flow of ischemic brain tissue, intravenous thrombolysis therapy can be given in the time window, and bridging endovascular interventional therapy if the effect is not good. Stent implantation is an effective remedy when conventional methods such as stent thrombectomy, aspiration thrombectomy and balloon dilatation fail to open the vessel. However, in some cases, vascular reocclusion may occur after stent implantation. If the occlusive vessel can not be revascularization quickly, the patient’s outcome can only be severe disability or death. This paper reports the diagnosis and treatment of a patient with vascular reocclusion after carotid artery stenting for acute carotid artery occlusion by femoral-carotid artery bypass. Femoral-carotid artery bypass is a new and effective surgical method, which can quickly solve this unusual but very difficult situation and is worth popularizing. [ABSTRACT FROM AUTHOR]

Cerebral infarction and acute myocardial infarction are both ischemic vascular diseases, with common risk factors, and may occur simultaneously or successively. Medullary infarction induces autonomic nervous dysfunction that affects cardiac nerves, and stress response after infarction can also lead to myocardial ischemic infarction. This paper reported the diagnosis and treatment process of a patient with bilateral medial medullary infarction complicated with acute myocardial infarction. The patient had no lesions on the MRI examination in the early stage of the disease, and the “heart” shaped infarct was found after several days of MRI reexamination. After antiplatelet aggregation and lipid-regulating treatment, there was still limb hemiplegia. This case emphasizes that patients with cerebral infarction should be given detailed physical examination, accessory examination and comprehensive evaluation of cardiac indicators to prevent misdiagnosis and missed diagnosis. [ABSTRACT FROM AUTHOR]

Giant cell arteritis (GCA) is a systemic granulomatous vasculitis that mainly affects the superficial temporal artery and the ophthalmic artery. The typical manifestation is the triad of headache, visual symptom and mandibular movement disorder. It is a neuroophthalmic emergency since it can cause profound visual loss. Hormone pulse therapy is the mainstay of treatment. This paper presents a rare GCA patient manifests as posterior ischemic optic neuropathy, and makes a comprehensive analysis of its clinical manifestations, laboratory examination and imaging examination. This case suggests that the diagnosis of GCA should be taken into account for elderly patients with severe vision loss accompanied by headache and no edema or atrophy in the optic nerve. [ABSTRACT FROM AUTHOR]

Central retinal artery occlusion (CRAO) is a vascular neuro-ophthalmic emergency, characterized by acute painless monocular vision loss, which is one of the main causes of blindness in middle-aged and elderly people. Currently, the pathogenesis and pathophysiological mechanism of CRAO is unclear, making the selection of appropriate animal models particularly important for the research on CRAO pathogenesis and the screening of therapeutic drugs. This paper mainly reviews the modeling methods and research progress of CRAO animal models, aiming to provide a reference basis for accurate diagnosis and treatment of CRAO. [ABSTRACT FROM AUTHOR]

Neuro-ophthalmic emergency refers to the spectrum of neuro-ophthalmic clinical diseases that can seriously threaten patients’ vision or even endanger their lives if they are not diagnosed and treated in time, among which the neuro-ophthalmic emergency caused by vascular causes (vascular neuro-ophthalmic emergency) accounts for the vast majority. Due to the characteristics of interdisciplinary, patients with vascular neuro-ophthalmic emergency are often first referred to the department of ophthalmology or emergency, and the first doctors often have incomplete understanding of the disease, which is easy to lead to delayed diagnosis, misdiagnosis or missed diagnosis of such patients. When patients are referred to the department of neurology, if the neurologist’s diagnosis of the disease cannot be determined in time, it is easy to delay treatment. In this paper, the clinical manifestations, the examination methods and the treatment methods of the major diseases in the spectrum of vascular neuro-ophthalmic emergency were reviewed in order to provide the basis for the rapid diagnosis and accurate treatment of these diseases. [ABSTRACT FROM AUTHOR]

Liver is the common site for metastasis and spread of non-small cell lung cancer (NSCLC). Lung cancer patients with liver metastasis have poor prognosis, which may be related to liver-specific microenvironment composition. The metastasis of lung cancer to the liver is regulated by various pathophysiological factors, including the liver immune microenvironment, related cells, proteins, signaling molecules, and gene changes. These factors will affect the consistent disease process and subsequent treatment strategies. Immune checkpoint inhibitors (ICIs) have made breakthroughs in treatment of patients with advanced NSCLC. However, NSCLC patients with liver metastasis, a unique population of advanced lung cancer, are characterized by poor immunotherapeutic effect. This paper reviews the related mechanisms of the immune microenvironment in affecting the occurrence and development of liver metastases and summarizes the achievements and prospects of anti-tumor immunotherapy in liver metastases of NSCLC. [ABSTRACT FROM AUTHOR]

Non-small cell lung cancer (NSCLC) is the most important histological type of lung cancer. This disease affects a large number of patients, and the prognosis of advanced patients is poor. Although great progress has been achieved for existing treatment methods, challenges still exist. Cancer is a genetic disease, and its occurrence is accompanied by substantial genomic-sequence instability. (GT/CA)n repeat sequence is a common microsatellite sequence serving as transcriptional function-related regions, DNA-methylation modification sites, and other functional sites. Its polymorphism is closely related to the expression of EGFR, HO-1, and HIF-1α in NSCLC patients. (GT/CA)n repeat sequence is the breakthrough point to explore the molecular mechanism of NSCLC occurrence and development, develop molecular markers for diagnosis and prognosis and epigenetics research. This paper summarizes the studies on (GT/CA)n repeat polymorphisms in NSCLC with the aim of providing references for relevant NSCLC research. [ABSTRACT FROM AUTHOR]

With the acceleration of the aging process and change in social lifestyle, the prevalence rate of late-life depression (LLD) in the elderly is increasing year by year. As the most common mental disorder in the elderly, LLD seriously affects the quality of life of patients, and thus brings a heavy burden to the family and society. It may even become life-threatening for the elderly patients. The pathogenesis of LLD is still unclear, which may be caused by a combination effects of biological, social and psychological factor. Given the declined body functions and more comorbid physical diseases in the elderly population, the diagnosis and treatment of LLD patients would be different from that of younger adult patients with depression. This paper reviews the epidemiological characteristics, clinical evaluation, diagnosis, comorbidity, treatment and intervention of LLD, and focuses on the selection of therapeutic drugs and adverse reactions, in order to provide references for better diagnosis and treatment of LLD and improve the prognosis of patients. [ABSTRACT FROM AUTHOR]

Post-stroke anxiety disorder (PSA) is a common psychiatric complication of stroke, which jeopardizes patients' recovery and their quality of life. Recent studies suggest that inflammation plays an important role in the pathogenesis of PSA. Therefore, this paper reviewed the related licture about the association between PSA and serum inflammatory biomarkers in order to provide references for the intervention of PSA. In this study, a comprehensive search was performed in China National knowledge Infrastructure (CNKI), Wanfang Data, Web of Science and PubMed database to identify the well qualified literature focusing on the relationship between PSA occurrence and serum inflammatory biomarkers, and a total of 13 studies were retrieved. Analysis indicates a certain association between PSA occurrence and serum inflammatory biomarkers, and denotes that the elevation of inflammatory biomarkers may be a trigger for the disease occurrence and its progression, but the specific mechanism underlying this relationship requires further study. [ABSTRACT FROM AUTHOR]

In the context of the information age and smart tourism, the government’s initiative to open up internal tourism data is conducive to releasing the commercial and social value of tourism data resources. This paper used the coefficient of variation method and the entropy weight method for combined weighting, constructed an evaluation index system for government tourism data opening, calculated the scores of 21 provincial administrative regions, and used fsQCA to compare high and low evaluation values with configuration analysis. The results showed that the index system included 4 first-level indicators, 17 second-level indicators and 51 third-level indicators, which effectively evaluated the performance of tourism data opening in provincial administrative regions; the utilization layer and data layer were the first-level indicators with higher weights, legal policy efficiency, content, platform relationship, etc. were second-level indicators with higher weights; high evaluation values were configured as comprehensive development type and data-assisted application type, and low evaluation values were configured as insufficient policy & utilization type and platform & data problem type. The research results are helpful to provide a reference prototype for the research and practice of tourism data opening evaluation. [ABSTRACT FROM AUTHOR]

As state-owned enterprises advance in digital transformation and intelligent renovation in China, the transfer of data assets has gradually emerged in traditional corporate property rights transfers and capital increase transactions, leading to various risk events. Firstly, the paper analyzes the deficiencies in compliance management of data asset transactions in state-owned enterprises. It then elaborates on the differences between data assets and traditional asset transactions of state-owned enterprises, including technological advancements that have derived new rights, and the two-tier transaction risks brought about by these new rights. Subsequently, it summarizes the new characteristics of data assets in state-owned enterprises: public welfare and benefits, sensitivity and competitiveness. Finally, it suggests that under the leadership of the enterprise party committee, efforts should be made to explore the establishment of a specialized legal and compliance review mechanism for data asset transactions. [ABSTRACT FROM AUTHOR]

To estimate changes in assets value is a crucial task of asset management and accountancy. The calculation of changes in the value of data assets is an urgent question in the current process of including data assets on the financial statements. Differing from traditional assets, data assets exhibit distinctive patterns in value fluctuation. To address this, it is essential to understand the factors contributing to the appreciation or impairment of data assets. This paper starts with the difference between data assets and traditional assets, analyzing different factors causing impairment or appreciation for assets value. Four factors of asset impairment were concluded, including the data timeliness factor, usage timeliness factor, management cost factor, and authorization deadline factor. Additionally, three factors of asset appreciation were analyzed, comprising the data integrity improvement factor, data usage discovery factor, and the factor of cost reduction caused by technology improvement. This exploration lays the foundation for the design of relevant calculation methods. [ABSTRACT FROM AUTHOR]