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Objective To establish a mouse model of pregnancy pain-depression comorbidity induced by chronic unpredictable stress (CUS), complete Freund's adjuvant (CFA), and formalin, and to systematically evaluate the associated phenotypes and preliminarily explore the pathological basis of the comorbidity. Methods Eight-week-old C57BL/6J female mice were randomly strarified divided into a control group (no intervention before pregnancy) and a CUS model group (CUS intervention before pregnancy) based on sucrose preference test (SPT) data. After completing the CUS treatment, female and male mice were paired and mated. Pain was induced by injecting 50% CFA and 5% formalin in the right hind foot during pregnancy to create a model of pregnancy pain-depression comorbidity. The experiment was divided into 8 subgroups: control-blank group, CUS-blank group, control-CFA group, CUS-CFA group, control-formalin group, CUS-formalin group, control-CFA+formalin group, and CUS-CFA+formalin group, with 10 mice in each group. The mice in each group were subject to behavioral tests, including the SPT, forced swimming test, tail suspension test, and open field test before and after CUS intervention, during pregnancy, and after delivery. Pain sensitivity changes were measured using mechanical allodynia and thermal hyperalgesia tests. Mice were then euthanized. Levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in hippocampus, as well as cortisol and adrenocorticotropic hormone (ACTH) in serum, were detected by enzyme-linked immunosorbent assay (ELISA). ResultsCompared with the control-blank group, the CUS-blank group showed a significant depression-like behavior with reduced pain threshold (P

ObjectiveTo investigate the infestation and disposal of bedbugs in Shanghai， and provide scientific evidence for comprehensive prevention and control of bedbugs.MethodsA questionnaire survey was conducted in the pest control operations （PCOs） of Shanghai Association for Health Promotion to investigate the infestation and disposal of bedbugs. The questionnaire included basic information of the unit， bedbug disposal experience， type of environment of bedbug infestation， main disposal site， main treatment method， main drug and formulation， and evaluation of the disposal. Chi-square test was used for comparison between groups.ResultsOf the 116 PCOs， 78 （67.24%） had conducted bedbug disposal， and 29.49% had conducted the disposal no less than 5 times in the past three years. The main types of environment of bedbug infestation were dormitories （46.96%）， hotels （18.78%）， and households （20.44%）. Additionally， bedbug infestation was found in nursing homes， prisons and detention centers， and transport vehicles. Bed frame/bed board/mattress （32.42%） was the main site of bedbug infestation， followed by mat （19.63%）. Chemical spraying was the most common method for bedbug disposal （98.72%）， followed by high-temperature steam （11.54%）. The main drug used in chemical spraying were pyrethroids （69.23%）， nicotinoids （60.26%） and organophosphorus （42.31%）， for which the main formulation were suspended insecticides （55.13%）， followed by wettable powders （43.59%） and emulsifiers （43.59%）. Furthermore， 89.74% of the PCOs performed the assessment after disposal， in which the control effect was generally satisfactory.ConclusionBedbug infestation is relatively common in Shanghai. Dormitories， hotels and households are places where bedbug infestation is more likely to occur. Bed frame， bed board and mattress are the most vulnerable sites to bedbug infestation. Combination of physical and chemical methods should be used for disposal of bedbug infestation.

Objective To explore the therapeutic effect of traditional Chinese medicine (TCM) on subsolid nodule (SSN). Methods A practical randomized controlled study method, including 254 SSN patients was adopted. The patients were divided into the TCM (102 cases) and follow-up (152 cases) groups. The follow-up group received regular check-ups in accordance with the guidelines, and the TCM group received TCM syndrome differentiation treatment for 24 weeks. The two groups were compared in terms of the changes in their SSN diameter, SSN number, TCM symptom score, and overall therapeutic effect before and after treatment. Adverse reactions and safety indicators were also recorded. Results The TCM group showed a significantly higher effective rate of treatment (16.7%) than the follow-up group (2.6%) (P

BackgroundNurses' moral courage is a special type of altruistic behavior， which is considered to be a key factor to improve patient safety. Empathy level can positively predict altruistic behavior， and moral sensitivity exerts an obvious mediation role in the positive prediction. At present， there is no relevant research to explore the path role of moral sensitivity in the relationship between empathy and moral courage.ObjectiveTo verify the mediation role of moral sensitivity in the relationship between empathy and moral courage among nursing students， so as to provide references for increasing the moral courage among nursing students.MethodsFrom June 1 to June 30， 2022， a total of 602 nursing students were recruited via convenience sampling from a tertiary grade A hospital in Mianyang， and participants were assessed using Interpersonal Reactivity Index-Chinese （IRI-C）， Moral Sensitivity Questionnaire-Revised Chinese Version （MSQ-R-CV） and Nurses' Moral Courage Scale （NMCS）. Pearson correlation analysis was used to assess the correlation among above scales. The Process macro plug-in for SPSS was used to test the mediation effect of moral sensitivity on the relationship between empathy and moral courage.ResultsA total of 602 valid questionnaires were collected， with an effective recovery rate of 96.78%. IRI-C score of nursing students was positively correlated with MSQ-R-CV score and NMCS score （r=0.269， 0.146， P

Anthocyanidin reductase is one of the key enzyme involved in the synthesis of flavonoids. In order to explore the structure of ANR gene, ANR enzyme expression pattern and flavonoid content under drought stress and their correlation, a HrANR gene identified from RNA-seq data of sea buckthorn was screened and analyzed by bioinformatics soft, the expression patterns of HrANR gene in different tissues and of flavonoid contents in leaves were performed. The results were as follows: (1) The ORF of HrANR gene was 1 017 bp, which encoded 338 amino acids. It was a stable hydrophilic protein, and the homologous protein had significant family and genus characteristics. (2) HrANR gene was expressed in roots, stems and leaves of sea buckthorn under drought stress, but the expression trends were different, with an increase followed by a decrease and then an increase in roots, a continuous decrease in stems, and an increase followed by a continuous decrease in leaves. (3) The flavonoid contents in leaves of sea buckthorn under different levels of stress showed a trend that first increased continuously and then decreased slightly, increased to the highest point after rehydration. The above results indicated that the expression of HrANR gene and the changes of flavonoid content were closely related to the drought resistance of sea buckthorn. The flavonoid content in leaves was positively correlated with drought stress at the beginning of drought stress and negatively correlated with drought stress under severe stress. (4) Leaf expression, stem expression and flavonoid content of HrANR gene were negatively correlated (Pleaf= -0.751, Pstem= -0.934) and root expression was positively correlated with flavonoid content (Proot= 0.444). The above results indicate that the expression of HrANR genes and changes of flavonoid content in sea buckthorn are closely related to drought resistance, and it provides a reference for elucidating the drought resistance mechanism of sea buckthorn.

ObjectiveTo present the exploration and application of a prospective follow-up research method for acute infectious disease surveillance based on natural community populations， using COVID-19 infection as an example， and to provide a reference for improving the infectious disease surveillance and early warning system.MethodsA multi-stage probability proportional sampling method was employed to sample residents from all communities of 16 administrative districts in Shanghai， with households as the units. A cohort for acute infectious diseases based on natural community populations was established. The baseline survey was conducted for all cohort subjects， and COVID-19 antigen test kits were distributed. From December 21， 2022 to September 30， 2023， prospective follow-up monitoring of COVID-19 antigen and nucleic acid was carried out on the study subjects on a weekly basis. The baseline characteristics and follow-up information of the cohort subjects were described.ResultsThe cohort for acute infectious diseases included a total of 12 881 subjects， comprising 6 098 males （47.3%） and 6 783 females （52.7%）. The baseline survey revealed that 35.2% （4 540/12 881） of the subjects had a history of COVID-19 infection. During the follow-up period from December 21， 2022 to September 30， 2023， the average incidence density in the cohort was 0.61/person-year， with a higher incidence density in females （0.63/person-year） compared to males （0.59/person-year）. Individuals aged 60 and above （0.64/person-year） and those with underlying health conditions （0.67/person-year） had a higher incidence density. Healthcare workers showed a notably higher incidence density （0.84/person-year） than that in other occupational groups. As of September 30， 2023， a total of 340 subjects in the cohort experienced secondary infections， with a median interval of 170 days between the first and second infections.ConclusionThis study applies cohort study method to acute infectious disease surveillance， providing crucial data support for estimating infection rates and forecasting alerts for acute infectious diseases in the community. This method can be promoted and applied as a new approach for acute infectious disease surveillance.

Background At present, polypharmacy is common among residents with high risk of unsafe medication due to the lack of drug reorganization and whole-course drug management. Community pharmacy services provided by community health service centers (CHSC) with regional advantages is in line with its functional orientation, but there is still a large gap between the supply of pharmacy services in CHSCs and the demand of the public. Objective To understand the current situation of community pharmacy services and the integration of pharmacists into family doctor team in Shanghai, as well as the problems faced by community pharmacy services, so as to provide suggestions for promoting the development of community pharmacy services. Methods A combination of qualitative and quantitative research was adopted. In December 2020, a stratified sampling method was used to conduct a questionnaire survey on 307 pharmacy staff on duty with licensed pharmacist qualification from 29 CHSCs, including 6 in the central urban area, 8 in the near urban area, and 15 in the far urban area. The questionnaire included the basic information of pharmaceutical staff, the development of community pharmacy services, and the participation of community pharmacists in the family doctor team. In the same period, a convenience sampling method was used to invite 29 key insiders, including 11 pharmacy section chiefs, 6 family doctor representatives, 12 community center directors and health commission managers from central urban area, near urban area and far urban area, to conduct a semi-structured focus interview on pharmacy service needs, pharmacy resource allocation and pharmacy service process. Results The quantitative research results showed that the highest proportion of community pharmacists participating in training is 1-2 times〔139 (45.3%) 〕, and the main form of training is continuing education, accounting for 252 (82.1%). The three most frequently conducted pharmacy service projects by community pharmacists are prescription dispensing〔284 (92.5%) 〕, prescription review〔253 (82.4%) 〕, and pharmaceutical window or outpatient consultation guidance〔196 (63.8%) 〕. The three longest service hours occupied by pharmacists are prescription dispensing〔280 (91.2%) 〕, prescription review〔244 (79.5%) 〕, and prescription comment〔145 (47.2%) 〕. A total of 78 (25.4%) pharmacists joined the family doctor team. The qualitative study showed that the elderly residents in the community had a great demand for pharmacy service, but their awareness of rational drug use was weak. In the allocation of community pharmacy resources, the pharmacists are lacjing, the professional quality needs to be improved, the community pharmacy drug list remains uncompleted, and the role of informatization needs to be strengthened. In the process of community pharmacy service, the recognition degree of community pharmacists is not high, with single service content and relatively little targeted training on rational drug use, and pharmacists fail to play a role in the family doctor team. Conclusion At present, the resource allocation and supply capacity of community pharmacy service cannot meet the needs of residents, and the pharmacy service process needs to be improved and optimized. The role played by the only part of pharmacists joining the family doctor team is limited. Therefore, it is necessary to increase the incentive mechanism, clarify the service content and improve the service model.

In order to study the effects of different functional strains on alleviating protein oxidation and enhancing flavor in fermented sausage, Lactiplantibacillus plantarum NJAU-01 (LpN), with excellent antioxidant activity, L. plantarum CGMCC 18217 (Lp10), with the ability to improve the flavor of fermented sausage, and Staphylococcus saprophytic CGMCC 3475 (Ss), with high protease activity, were selected for use in a multi-strain starter culture for fermented sausage. The degree of protein degradation and oxidation in fermented sausage during fermentation and the final flavor of the product were evaluated. The results showed that the Lp10 + LpN + Ss starter culture could reduce the degree of protein oxidation in fermented sausage and increase the types and contents of volatile flavor substances, while endowing fermented sausage with better color and improving its texture characteristics, and the fermented product had high sensory scores. This study showed that the combination of Lp10, LpN and Ss could improve the quality and flavor of fermented sausage while delaying the oxidation of protein.

Objective To examine the differences in therapy response and confirm the effective regimen for multiple myeloma (MM) patients with t (11; 14)/CD20- or CD20+, for the selection of transplantation as early treatment. Methods To find the differences in therapy response and to confirm the effective regimen for multiple myeloma (MM) patients with t (11; 14)/CD20- or CD20+, for the selection of transplantation as the early treatment. There were three cytogenetics groups: t(11; 14)/CD20- or CD20+ and low-risk profile including normal or cytogenetics other than t (11; 14). Eligible patients received the bortezomib-based induction and lenalidomide-based consolidation/maintenance regimen. Results Patients with t(11;14) gained adverse therapy response for bortezomib induction regimen than other low-risk arm (OR rate: 11.1% versus 84.0% versus 85.2%, P＜0.01). A prospective found that although the patients with t(11;14)/CD20- showed the poor overall response for the bortezomib-based regimen, lenalidomide-based treatment schedule makes them gain a similar therapy advantage comparing with t(11;14)/ CD20+ and other low-risk group in the study The subgroup analyses of progression-free survival(PFS) and overall survival(OS) by continued lenalidomide-based consolidation/maintenance treatment also showed a benefit for lenalidomide therapy compared with observation regardless of cytogenetic risk profile and response at baseline (PFS at 4 years reached 75.0% versus 77.1% versus 84.2%, OS at 4 years was 75.0% versus 88.5% versus 90.4%, respectively). Moreover, the lenalidomide regimen little induced the incidence of fatal complications and was tolerated. There were only 3.2%, 8.4% and 15.8% patients had agranulocytosis, peripheral neuropathy and infection of 3-4 grade. Conclusions Lenalidomide regimen is more effective for t (11, 14)/ CD20- risk MM and t(11;14)/CD20+ and other cytogenetically low-risk MM are consistent in PFS and OS. In addition, the initial response rate of MM patients with unsatisfactory bortezomib treatment can also be improved.

BackgroundBeing complex and highly heterogeneous with regard to the etiology and clinical manifestations of depression， neuroimaging studies make a breakthrough for exploring the biological subtypes of depression， while the current data-driven approach for the identification of subtyping depression using structural magnetic resonance imaging （MRI） data is insufficient.ObjectiveTo explore the biological subtypes of depression using diffusion tensor imaging （DTI） and machine learning methods.MethodsA total of 127 patients with depression who attended Beijing Anding Hospital from September 2017 to August 2021 and met the Diagnostic and Statistical Manual of Mental Disorders， fourth edition （DSM-IV） diagnostic criteria were included， and another 80 healthy individuals matched for gender and age were recruited through advertisements in surrounding communities during the same period. DTI findings， demographic characteristics and clinical data were collected from all participants. Tract-based spatial statistics （TBSS） and the Johns Hopkins University （JHU） white matter probability maps were used to extract fractional anisotropy （FA） values of white matter tracts. A semi-supervised machine learning technique was used to identify the subtypes， and the FA values for whole brain white matter of patients and controls were compared.ResultsPatients with depression were classified into two biological subtypes. FA values in multiple tracts including corpus callosum and corona radiata of subtype I patients were smaller than those of healthy controls （P0.05）， while subtype I patients scored lower on HAMD-17 than subtype II patients after 12 weeks of treatment （t=2.410， P

In this paper, based on the research background of recovering uranium from wet-process phosphoric acid(WPA) by amino phosphonate acid chelating resin, the distribution of uranium in single particle amino phosphonate chelating resin was studied. The results show that the optimal laser frequency of LA-ICP-MS is determined to be 6 Hz, the beam spot diameter is 44 μm, and the energy density is 6 J/cm2. The resin with saturated adsorption and the resin with complete elution were selected as the external standard of the adsorption and leaching process, and the homogeneity test was carried out. The relative standard deviation of uranium content in the resin with saturated adsorption and the resin with complete elution are 3.87% and 3.52%(n=9), respectively. Uniformity is good. In situ microzone analysis of uranium in amino phosphonic acid chelating resin was carried out by LA-ICP-MS. The adsorption process of uranium on the resin is gradually completed from the outside to the inside, and the leaching process is gradually completed from the outside to the inside, and the concentration of uranium inside and outside the resin is gradually uniform and unified, and finally reaches adsorption saturation and leaching complete.

Background In China, schizophrenia patients have a high demand for basic medical care, but irrational healthcare-seeking behaviors among them may cause a waste of health resources. So relevant policies have been promulgated to improve the ensuring of healthcare and reasonably guide schizophrenia patients to seek medical care. The current research on policy factors and healthcare-seeking behaviors has rarely addressed the association between mental health policies and healthcare-seeking behaviors of patients with schizophrenia. Objective To analyze the influence of policy factors on healthcare-seeking behaviors in schizophrenia patients, to understand the status and outcome of health service utilization in this group under the guidance of basic medical insurance policies and mental health policies, providing empirical evidence for policy improvement. Methods In November 2019, we obtained a sample of 2 314 schizophrenic individuals with valid key data by matching the personal data in the three-level psychiatric prevention and treatment network system in a district of Chongqing in 2018, with information related to personal health service utilization in the district obtained from the medical insurance information platform of Chongqing Human Resources and Social Security Bureau. Multivariate Logistic regression analysis was conducted with healthcare-seeking behaviors and the medical institution chosen for treatment as explained variables, participation in basic medical insurance (including basic medical insurance for rural and urban non-working residents or basic medical insurance for urban employees, and reimbursement for medical cost due to special outpatient diseases) and mental health policy coverage (involving community rehabilitation services, guardianship subsidy, subsidy from the local disability federation, subsidy from the 686 program, and free second-generation antipsychotics, and the mental disability certificate) as key explanatory variables, and patients' demographic characteristics as control variables. Results Of the participants, 1 915 (82.76%) had medical visits, including 1 482 seeking outpatient treatment, and 795 seeking inpatient treatment. Among those seeking outpatient treatment, the prevalence of choosing primary, secondary and tertiary care institutions was 17.01% (252/1 482), 72.87% (1 080/1 482), and 10.12% (150/1 482), respectively. And the prevalence of choosing primary, secondary and tertiary care institutions for inpatient treatment was 4.78% (38/795), 65.16% (518/795), and 30.06% (239/795), respectively. Logistic regression analysis showed that the type of basic medical insurance, reimbursement for medical cost due to special outpatient diseases, receiving community rehabilitation services, enrolment in the 686 program and involvement in the free second-generation antipsychotics program were factors associated with healthcare-seeking behaviors (P

Due to the lack of domestic 980 nm pump laser design experience and production process, the key technology of high power 980 nm pumped laser to break through. In this paper, a 980 nm pump laser with 400 mW output power has been successfully developed by using a domestic solution, including the design and implementation of chips, gratings and coupling fibers. By using the all metallized package directly coupled with wedge-shaped fiber and selecting the double grating structure for wavelength locking, the wavelength stability of the 980 nm pumped laser with 400 mW output power in the operating temperature range of -50~75 ℃ can reach 0.01 nm/ ℃. Moreover the 980 nm pump laser has passed the 800 mA charge aging at 75 ℃ for more than 5 000 h. This has laid a foundation for the research of domestic pump lasers with high reliability.

Objective To study the mechanism of learning and memory impairment in aged female mice caused by chronic stress. Methods Twenty-month-old ICR mice were randomly divided into four groups: control females, control males, stressed females, and stressed males. Chronic stress was applied to the stress group for 30 days. The learning and memory ability was measured by novel object recognition test and Morris water maze test. Damage to hippocampal neurons was observed with Nissl staining, and dendrites of hippocampal neurons were observed with Golgi-Cox staining microscopy, the expression of the mammalian target of rapamycin (mTOR) and p-mTOR in hippocampal tissue was measured by Western blot, and the level of serum corticotropin-releasing hormone (CRH) was measured by ELISA. Results There was a significant decrease in the learning and memory ability only in the stressed female group after applied stress. In the Morris water maze, after a 6-day swimming training, the escape latency decreased in the control female group, the control male group and in the stressed male group(P＜0.001, P＜0.001, P＜0.05), but not in the stressed female group. The swimming speed was consistent across groups, but the number of platform crossings and the number of target quadrant crossings were significantly lower in the stressed female group than those in the control female and stressed male groups(P＜0.001).There was significant damage to neurons in the hippocampal CA3, CA1, and DG regions of mice in the stressed female group. The expression of hippocampal m-TOR and p-mTOR protein was significantly decreased in the stressed female group of mice(P＜0.05). In addition, chronic stress caused a significant increase in serum CRH levels in aged female mice(P＜0.05). Conclusions Chronic stress caused learning and memory impairment and pathological damage of the hippocampus in aged female mice, but not in aged male mice, which may be related to a fact that chronic stress elevates CRH and inhibits the hippocampal m-TOR signaling pathway in aged female mice.

Tooth surface pitting is one of the main faults of helical gear. A large number of experimental data are needed for the diagnosis of pitting corrosion faults on different tooth surfaces and different degrees. Therefore, a method combining simulation and experiment is proposed to identify the degree and quantity of pitting corrosion on helical gear tooth surface. The envelope spectrum analysis of dynamic response signals is carried out, and the characteristic response laws of different pitting fault types in time domain and frequency domain are obtained. Through the characteristic analysis of the vibration signal of gear contact fatigue experiment, the accuracy of the dynamic model of helical gear pitting corrosion fault is verified. The results show that the gear pitting fault dynamic model can diagnose and identify the pitting corrosion degree of single tooth surface and multi tooth surface, and provide a diagnostic basis for transmission gear fault diagnosis and health prediction.

The pipeline design is one of the important contents of coal preparation plant design. At present, pipeline of coal preparation plant mainly depends on the manual design, which is difficult, time-consuming and difficult to guarantee the quality of pipeline layout. When A* algorithm is applied to the automatic layout of three-dimensional pipeline in coal preparation plant, the searched path does not meet the requirements of pipeline design. In order to solve the above problems, an automatic pipeline layout method for coal preparation plant based on optimized A* algorithm is proposed. Based on the pipeline layout rules of coal preparation plant, the layout space model of coal preparation plant is established. The grid and numerical processing are carried out on the layout space model. Aiming at the problem that the path searched by the A* algorithm has excessive bending, the evaluation function of the A* algorithm is optimized. To solve the problem of the slow search speed of the A* algorithm, dynamic weight are introduced into the evaluation function. Aiming at the problem that the pipeline path searched by the A* algorithm after the above optimization will bypass the required equipment, the direction-oriented strategy is introduced to improve the engineering practicability of pipeline layout. To improve the A* algorithm's operation efficiency, the Open table's array structure is replaced with the minimum binary heap structure. The simulation result shows the following points. ① After optimizing the evaluation function of the A* algorithm, the bending times of the pipeline path are reduced by about 80%. The ben is right angle, which accords with the actual situation of the pipeline layout in the coal preparation plant. After introducing the dynamic weight, the operation efficiency is improved and the path quality can be guaranteed. ② The path length of the pipeline before and after the direction-oriented strategy is introduced has no change. The lengths meet the basic constraint rule of the pipeline layout of the coal preparation plant. After the introduction of the direction-oriented strategy, the pipeline is more likely to be planned near the equipment with specific requirements for the pipeline. And the pipeline has a tendency to be arranged side by side. This indicates that the pipeline layout after the introduction of the direction-oriented strategy meets the requirements of the optimal overall layout, and is more consistent with the coal preparation engineering application. ③ The efficiency of A* algorithm after Open table optimization is improved obviously. The longer the pipeline path and the more obstacles in the middle, the more significant the efficiency improvement of the A* algorithm. The software system of automatic pipeline layout in the coal preparation plant is designed and developed. The application example of the optimized A* algorithm is verified. The results show that the optimized A* algorithm improves the efficiency and quality of piping design in the coal preparation plant, and has better visibility.

BackgroundAccurately calculating the borehole size and standoff between the tool and borehole wall is the premise for correcting the effect of the borehole environment and improving measurement precision in logging while drilling (LWD).PurposeThis study aims to obtain an accurate calculation method for the standoff size of LWD.MethodsFirstly, the theoretical relationship of the standoff was derived based on the broad-beam γ-ray attenuation model for azimuth density LWD. Then, Monte Carlo N-Particle transport code (MCNP) was employed for simulation, and results were benchmarked according to experimental tool data. By analyzing the influence of standoff, mud and formation density, and other factors on the detector response, an accurate standoff calculation formula was derived. Finally, logging curves were drawn using the CIFLog platform and the calculated standoff results were compared with the measured ultrasonic results, hence to verify the accuracy of the proposed standoff calculation method.ResultsThe calculated standoff results in the simulation are fundamentally consistent with the theoretical value. The calculation result using measured data processing is in approximate agreement with the ultrasonic standoff, and the calculated calipers have good correspondence with the wireline well diameter. The proposed method provides accurate measurement even when the standoff is small and ultrasonic standoff measurement is abnormal. The applicable range of standoff calculation based on azimuthal density LWD is 0~3.81 cm.ConclusionsThe broad-beam γ-ray attenuation based standoff calculation method for density LWD complements to larger range ultrasonic measurements to provide key parameters for borehole correction for LWD tools.

Education is the first step toward revitalizing the rural. The rational allocation of rural compulsory education resources is an important means of achieving comprehensive social development and urban-rural integration. This study used the Densi-Graph urban and rural identification method method to accurately identify urban and rural areas at the grid scale within the administrative division. Taking the rural area of Chongqing as an example, based on resource coverage, environmental constraints, and accessibility, this study explored the spatial differences in compulsory education resource availability. A spatial regression model and geographical detector were used to determine the main influencing factors. In order to provide data support and decision-making reference for the availability of rural compulsory education resources and spatial optimization of schools. The results show that the following: First, there is a significant difference between urban and rural areas based on the Densi-Graph urban-rural identification method, with the rural area of Chongqing reaching 79,752 km2, accounting for 96.82% of the total area; the urban area is 2,616 km2, accounting for only 3.18% of the total area, and is concentrated in the central city. There are significant circle layer increasing characteristics in the distribution of rural areas. From the central urban area to the periphery, the proportion of urban areas gradually decrease, and the proportion of rural areas gradually increase. The proportion of rural areas in the central urban area is 80.12%; the area of rural areas in the pioneering development areas of the same city, important strategic pivot cities, and bridgehead cities account for 95.81%, 96.32%, and 97.04%, respectively, which are higher in southeast and northeast Chongqing. Second, the availability of compulsory education resources in Chongqing has obvious spatial agglomeration and spatial correlation characteristics. High-level areas are clustered around the central urban area and scattered in the central area of the townships. Low-level areas are concentrated in backward mountainous areas, such as Chengkou, Wushan, and Pengshui. Specifically, high-level resource coverage areas are in a point-like agglomeration state in northeast and southeast Chongqing. The polarization of accessibility is significant. High-level areas only appear around the central urban area, while low-level areas are widely distributed in the west, northeast, and southeast of Chongqing. The degree of environmental constraint varies with terrain, and the spatial differences are small. A small number of low-level regions are concentrated at the junction of Chengkou, Kaixian, and Wuxi, with large terrain fluctuations. Overall, the availability level of compulsory education resources in rural areas of Chongqing shows a spatial difference pattern of decrease from the urban center to the periphery. Third, the degree of government attention, level of social and economic development, level of transportation facilities, and natural geographical environment are all related to the availability of compulsory education resources, but the degree of influence varies. Location dominance, slope, and topographic relief are negative factors, whereas the remaining factors play a positive role. Fourth, regional socioeconomic development affects the distribution of regional compulsory education resource points and investment in compulsory education, which is the basis for affecting the availability of resources. Public transport routes and traffic site density are key indicators affecting the availability of compulsory education resources, and there is significant interaction between social and economic development and education investment. Guaranteeing investment in education, optimizing the distribution of compulsory education points, and strengthening public transportation are equivalent to providing financial support and government attention. These are at the core of guaranteeing improvement in the level of availability of compulsory education resources in rural areas.

BackgroundThe use of controlled X-ray sources instead of 137Cs radioactive sources in density logging has become a new trend. The high voltage on the target substrate significantly affects the intensity of the X-ray source, and the density measurement uncertainty can be maintained at 0.01 g∙cm-3 when the high voltage is 350 kV.PurposeThis study aims to examine the depth-of-investigation characteristics and influence of a 350-kV high-voltage X-ray density logging instrument.MethodsThe depth of investigation of various source distance detectors in 20% water-bearing limestone formation was studied using the Monte Carlo method. By comparing the investigation characteristics of 350-kV high-voltage X-ray source and 137Cs source density logging, the reasons for the differences in the depth of investigation among them were analyzed. Moreover, the contribution of mudcake and formation to the detector and the density deviations of various detectors were analyzed via simulation. Finally, the influence of mudcake on the density logging response of the well wall was explored.ResultsThe results indicate that the depth of investigation of X-ray density logging instrument increases with the augment of source distance. Compared to the 137Cs source density logging, the scattered particles of the X-ray density logging are mainly concentrated at 1~3 cm from the bore wall, resulting in the depth-of-investigation differences between the two techniques. Furthermore, the contributions of mudcake and formation to different source distance detectors are different, and the detector density deviation decreases with the increase in source distance.ConclusionsThis study affords a theoretical basis for the depth-of-investigation characteristics and influence of 350-kV high-voltage X-ray density logging.

In order to accurately identify mine microseismic signals, this paper proposes a VGG4-CNN deep learning network model suitable for identifying mine microseismic signals. The model is written in Python language and built based on the PyTorch deep learning network architecture framework. Based on the time-domain characteristics of the microseismic signals of 9 types of events such as rock fracture, blasting operations, and background noise in the mine production process, VGG4-CNN has realized the supervised learning training and classification recognition application of 3 835 sets of mine microseismic signal data. The research results show that the recognition accuracy of the VGG4-CNN neural network constructed in this paper is as high as 94 %. This model does not require denoising of the original waveform signal and is more robust than other models. The implementation can be performed by a medium-level GPU to meet engineering requirements.

Several equipment clamps of main transformer in a nuclear power company were broken. Taking samples from the broken equipment clamps and the same batch of spare equipment clamps, the fracture causes were analyzed through macroscopic inspection, penetrant testing, metallographic analysis, micro morphology testing, crimping quality testing, conductivity testing and XRD testing. The main reason for the fracture is that the equipment clamp bears all kinds of stress under the condition of insufficient strength and performance degradation, and finally cracks appear at the weakest part of the weld, forming fracture. In order to avoid the occurrence of similar accidents, it is suggested to strengthen the metal supervision and strictly control the quality of the access equipment.

Telomerase reverse transcriptase is a subunit of telomerase, which plays an important role in activating telomerase and regulating cell cycle. Human telomerase reverse transcriptase(hTERT) is mainly expressed in germ cells, embryonic stem cells and tumor cells, only a few expressed in normal cell. hTERT is mainly located in nucleus and also distributed in mitochondria. hTERT migration from nucleus into mitochondria is called the mitochondrial translocation of hTERT. Mitochondrial translocation of hTERT functions in the process of apoptosis, immortalization and drug resistance. Control of hTERT is a potential breakthrough in the treatment of diseases.

ObjectiveBy comparing some key factors in generating bacterial artificial chromosome (BAC) transgenic mice, such as the background of strains, the concentration of the BAC DNA used for injection, the size of the BAC DNA, and the storage time of the BAC DNA injection, to optimize the generation of BAC transgenic mice.MethodsThe same procedure of BAC DNA preparation was used with two mouse strains, i.e. C57BL/6J and FVB/N to produce embryos; four concentrations of DNA for injection (0.75, 1.0, 1.5, and 2.0 ng/µL, respectively) were utilized to microinject into the embryos. The size of BAC DNA fragment and the time from BAC preparation to injection were recorded, and the birth rate and positive rate of transgenic mice were compared.ResultsThe positive rate of transgenic mice with FVB/N background was higher than that of C57BL/6J background (P < 0.05). When different concentrations of BAC DNA were adopted, the birth rates of C57BL/6J and FVB/N mice from high to low were 0.75 ng/µL>1.5 ng/µL>1.0 ng/µL>2.0 ng/µL. When the injection concentration was 1.5 ng/µL, the positive rates transgenic mice in C57BL/6J and FVB/N newborns were the highest, while the positive rate was 0 in C57BL/6J newborns when the injection concentration was 0.75 ng/µL and 2.0 ng/µL. When different concentrations of BAC DNA were adopted, the positive rate of transgenic mice in FVB/N newborns from high to low was 1.5 ng/µL>1.0 ng/µL>2.0 ng/µL>0.75 ng/µL. When the BAC fragment size was 197 kb, the mice birth rate was highest at (22.49±9.41)%, and when the fragment size was 99 kb, the birth rate was lowest at (13.61±15.65)%. When the BAC fragment was 197 kb, the transgenic mice had the highest positive rate of (13.56±12.88)%, extremely significantly higher than that for 114 kb (P < 0.01) and significantly higher than that for 99 kb (P < 0.05). The storage time of BAC injection was not linearly associated with the positive rate of transgenic mice.ConclusionCompared with C57BL/6J, mice with FVB/N background appear more suitable for the generation of BAC transgenic mice. When the concentration of BAC DAN injection is 1.5 ng/µL, the positive rate of transgenic mice is the highest. BAC fragment size is not a constraining factor for positive transgenic mice. The highest efficiency is expected when the BAC DNA is injected within one week after preparation.

Objective To detect the level of related indexes of energy metabolism in liver tissue of alcoholic liver disease (ALD) mice, and to explore the intervention effect of Gehua Jiejiu Dizhi Decoction.Methods Forty male C57BL/6J mice were randomly divided into the normal control group, the model group, the Gehua Jiejiu Dizhi Decoction high-dose group (4.94 g/kg), the Gehua Jiejiu Dizhi Decoction low-dose group (2.47 g/kg), and the resveratrol group (0.40 g/kg), with 8 mice in each group.Except the normal control group, the mice in other groups were fed with Lieber-DeCarli control liquid diet for five days, followed by Lieber-DeCarli alcohol liquid diet for ten days, and on the 16th day, the mice were given 31.5%alcohol solution through gavage to establish the ALD model.From the second day after modeling, the rats in the intervention groups were given the corresponding drugs by gavage once a day for nine consecutive days.Hematoxylin and eosin staining and oil red O staining were used to observe the liver steatosis in liver tissue.The activities of Na+K+-ATPase and Ca2+Mg2+-ATPase, and the contents of succinate dehydrogenase (SDH) and hepatic glycogen in liver tissue were detected using spectrophotometry.The contents of ATP, ADP, AMP, the AMP/ATP value, total adenosine pool (TAN) content, and energy charge (EC) in liver tissue were detected by reversed phase high performance liquid chromatography method.The mRNA expressions of NAD dependent deacetylase Sirtuin-1 (SIRT1) and AMP-activated protein kinase (AMPK) a2 in liver tissue were detected by real-time PCR.The protein expressions of SIRT1, AMPKa2, and AMPKTNF-β1 in liver tissue were detected by Western blotting.Results Compared with the normal control group, the model group mice showed significant hepatic steatosis, significantly decreased Ca2+Mg2+-ATPase activity and SDH content in liver tissue, significantly increased hepatic glycogen content, significantly decreased EC and AMP/ATP value, significantly increased ATP, ADP, AMP, and TAN content, significantly decreased mRNA expressions of SIRT1 and AMPKa2, significantly increased protein expression of AMPKTNF-β1 (P < 0.05). Compared with the model group, the Gehua Jiejiu Dizhi Decoction high-and low-dose groups significantly reduced liver tissue steatosis, and the activity of Na+K+-ATPase in liver tissue was significantly reduced, the EC and the mRNA expressions of SIRT1 and AMPKa2 were increased (P < 0.05); the activity of Ca2+Mg2+-ATPase, SDH and ATP contents were increased in the Gehua Jiejiu Dizhi Decoction low-dose group (P < 0.05); the AMP/ATP value was increased in the Gehua Jiejiu Dizhi Decoction high-dose group (P < 0.05); and the protein expression of SIRT1 was increased in the the Gehua Jiejiu Dizhi Decoction high-and low-dose groups and the resveratrol group (P < 0.05); the protein expression of AMPKa2 in the Gehua Jiejiu Dizhi Decoction low-dose group and the resveratrol group was increased (P < 0.05). Compared with the Gehua Jiejiu Dizhi Decoction high-dose group, the Gehua Jiejiu Dizhi Decoction low-dose group and the resveratrol group showed a significant increase in ATP, TAN contents, and EC in liver tissue, while the AMP/ATP value decreased (P < 0.05); mRNA expressionin of AMPKa2 in the Gehua Jiejiu Dizhi Decoction low-dose group was decreased (P < 0.05); and the protein expressions of SIRT1 and AMPKa2 in the resveratrol group were increased (P < 0.05). Compared with the Gehua Jiejiu Dizhi Decoction low-dose group, the protein expression of AMPKTNF-β1 was decreased in the resveratrol group (P < 0.05). Conclusion The changes of energy metabolism caused by chronic alcohol intake may be related to the occurrence of ALD, and the intervention of Gehua Jiejiu Dizhi Decoction can improve the abnormal energy metabolism in the liver of ALD mice. [ABSTRACT FROM AUTHOR]

The microstructure and mechanical properties of different heat-treated K4169 alloys after standard heat treatment (SHT), hot isostatic pressing + standard heat treatment (HIP + SHT) and hot isostatic pressing + heat treatment without homogenization (HIP + HTWH) were compared. The feasibility of heat treatment without homogenization of K4169 alloy after HIP was analyzed. A suitable heat treatment system for casting K4169 alloy was proposed. The results on microstructure show that the hot isostatic pressing (1170 °C/140 MP/4 h) can basically eliminate the Laves phase and δ phase of the alloy. Compared with the alloys after HIP + SHT, discontinuous short rod-like δ phase is existed at some grain boundaries of the sample without homogenization heat treatment (HIP + HTWH), which has no substantial influence on the uniformity of microstructure. The results on mechanical properties show that compared with the alloys after SHT, the yield strength at room temperature of alloys after HIP + SHT and HIP + HTWH is increased by 73 MPa and 91 MPa, and the stress-rupture life (704 °C / 448 MPa) is increased by 35% and 32% respectively. Although the dispersion of stress-rupture life and plasticity for alloys after HIP + HTWH are higher than that of HIP + SHT, the mechanical properties meet the requirements of AMS5383 for K4169 alloy. The HIP+HTWH heat treatment process has the practical application potential for K4169 alloy structure by comprehensive analysis of various factors such as reduction of process cost, the increase of production efficiency and the improvement of mechanical properties.

Objective To explore the mechanism of short-chain fatty acids in alleviating γδT cell-mediated inflammatory response. Methods A certain concentration of short-chain fatty acids was used to intervene in rat intestinal-derived γδT cells. CCK-8 was used to detect the effect of shortchain fatty acids on γδT activity. ELISA was used to detect the content of the IL-17A, RT-qPCR was utilized to detect the expression of the IL-17A, and flow cytometry was applied to analyze the IL-17+ γδT cell frequency. The effect of SCFAs on IL-17A and NF-κB signaling pathway in γδT cells were observed by Western blot. Results CCK-8 assay showed that the concentration of sodium acetate was less than or equal to 0.5 mmol/L, and the concentrations of sodium propionate, sodium butyrate, and mixed short-chain fatty acids were less than or equal to 0.25 mmol/L, indicating no inhibitory effect on the proliferation of γδT cells. ELISA and RT-qPCR showed that the treatment of γδT cells with sodium propionate, sodium butyrate, and mixed short-chain fatty acids significantly decreased the levels of IL-17A compared with the control group. Flow cytometry revealed a significant decrease in the proportion of IL-17+ γδT cells under the treatment of sodium propionate, sodium butyrate, mixed shortchain fatty acids, and TSA intervention. Western blot found that sodium propionate, sodium butyrate, and mixed shortchain fatty acids could inhibit the expression of IL-17A and IKK, as well as the phosphorylation level of NF-κB. Conclusion Shortchain fatty acids could inhibit the activation of IL-17A and NF-κB signaling pathway in γδT cells, thereby alleviating the inflammatory response in the body. [ABSTRACT FROM AUTHOR]

Objective: To investigate the active components, protein targets, and mechanisms underlying the anti-obesity effects of Hippophae fructus using network pharmacology and molecular docking techniques, and to validate its in vitro anti-obesity efficacy. Methods: The TCMSP platform was utilized to retrieve the active components and targets of Hippophae fructus, and disease targets were collected. Venny 2.0.2 was used to identify the intersection of targets between Hippophae fructus and obesity-related targets. The STRING database was used to establish a drug-target-disease protein interaction (PPI) network. The intersecting targets were analyzed using the David database to perform GO enrichment analysis and KEGG pathway analysis. Cytoscape 3.9.1 was used to construct a network diagram of the components of Hippophae fructus, anti-obesity targets, and related signaling pathways. Autodock Dock 1.5.7 and Pymol 2.2.0 were used to carry out molecular docking between the core targets of Hippophae fructus and its components, followed by visualization. The in vitro anti-obesity effect of Hippophae fructus extract was evaluated through cell experiments using 3T3-L1 cells. Results: A total of 33 active components, 2820 disease targets, and 151 intersection targets of Hippophae fructus were identified. The main active components included flavonoids, vitamins, and sterols, while key targets involved AKT1, TNF, IL6, TP53, VEGFA, CASP3, and others. KEGG pathway enrichment analysis revealed 131 signaling pathways, including those related to malignant tumors, lipid and atherosclerosis, and AGE-RAGE signaling. Molecular docking results demonstrated favorable binding interactions between the core targets and the corresponding active components of Hippophae fructus. The in vitro experiments indicated that Hippophae fructus extract exhibited inhibitory effects on the proliferation of 3T3-L1 pre-adipocytes. Conclusion: This study reveals that Hippophae fructus exerts antiobesity effects through multiple components, targets, and pathways, providing valuable insights for its clinical research and product development. [ABSTRACT FROM AUTHOR]

In order to prepare broadband and high-efficiency flexible fabrics, ferrite (Fe3O4)/graphene (rGO) absorbing particles were prepared by thermal decomposition method, and Fe3O4/rGO nanoparticles were loaded onto cotton fabrics by double immersion and double rolling to obtain flexible fabrics with excellent absorbing properties. Scanning electron microscopy and infrared spectroscopy were used to characterize the microstructure and composition of flexible fabrics, and the electromagnetic parameters of fabrics were tested and analyzed. The results show that when the load-to-mass ratio of Fe3O4/rGO is 15:1, the absorption effect of flexible fabric is the best. When the thickness of the composite absorber is 4 mm, the minimum reflection loss at 11.3 GHz reaches -18.4 dB, and the effective absorption bandwidth ranges from 10.63~11.72 GHz. This paper provides a reference for the design and development of high-efficiency and broadband flexible absorbers. [ABSTRACT FROM AUTHOR]

The technology of cotton leaf removal is an important prerequisite for realizing the mechanical harvesting of cotton, but low temperature affect the efficiency of TDZ-induced leaf abscission, which cannot meet the requirements of mechanized harvesting. In our laboratory, we found that cyclanilide (CYC) could improve the defoliation efficiency of TDZ at low temperature, but the mechanism of CYC promoting chemical defoliation (TDZ) under low temperature is unknown. Therefore, the content of plant hormones and the relative expression level of related genes in the abscission zone of cotton leaves were analyzed using Zhongmian 425 as the experimental material, setting two temperature levels (25 and 15 ) and three treatments [water (CK), single TDZ (T), and the compound of TDZ+CYC (TC)]. At 240 h after treatment under low temperature (15 ), the abscission rate of cotton leaves treated by T was only 53.0%, while the start time of cotton leaves abscission treated by TC was 24 h ahead of that treated by T and the abscission rate of cotton leaves treated by TC increased to 79.6%. At low temperature, compared with T, the relative expression level of auxin (IAA) transport genes (LAX2, PIN1), IAA response genes (IAA9, ARF3) and the content of IAA in the abscission zone of cotton leaves treated with TC were reduced significantly; the relative expression level of ethylene (ET) synthesis genes (ACS, ACO), and the content of ET synthesis precursor ACC were increased, the relative expression level of ET downstream signal gene(ERF1B) was up-regulated significantly in the abscission zone treated with TC. The jasmonate acid (JA) synthesis-related gene (AOC4) was up-regulated, and the content of JA was increased in abscission zone treated by TC. The inhibition of the IAA transport and signal transduction and the promotion of ET and JA synthesis and ET signal transduction caused by TC treatment in the abscission zones of cotton leaves could be the key reason that CYC could promote cotton leaves abscission effect of TDZ at low temperature. [ABSTRACT FROM AUTHOR]

In order to explore the pre-ignition reaction of aluminum/polytetrafluoroethylene (AI/PTFE) material, AI2O3/PTFE composites were prepared by ultrasonic mixing method. The crystal structure, microstructure and thermochemical properties were characterized and the thermochemical reaction characteristics and influencing factors were analyzed. The results show that AI2O3 can delay the initial temperature of PTFE melting. The smaller the particle size of Al2O3 and PTFE, the easier it is for the Al2O3 /PTFE material to re-act and release more heat. AI2O3 with small particle size can delay the initial temperature of AIF3 formation reaction and advance the initial temperature of AIF3 crystal transformation reaction, thus increasing the concentrated heat release of the reaction. The reaction degree of AI2O3 (50nm) and PTFE (1 jum ) is the highest. The thermochemical reaction properties of a-AI2O3/PTFE are better than those of y-AI2O3/PTFE and amorphous AI2O3/PTFE. The thermochemical reaction of AI2O3/PTFE exhibits the typical kinetic charac-teristics. With the increase of the heating rate, the peak temperature of the main heat release peak of the reaction increases. The calculated apparent activation energy of AI2O3/PTFE reaction is 45.0kJ/mol. [ABSTRACT FROM AUTHOR]

In our present stage, agricultural water right trading is dispersed and the scale is smaller, and the market activity of agricultural water right trading is not in full swing. With the contradiction between supply and demand of water resources becoming increasingly tense, agriculture has necessity to stimulate the decisive role of market in water resources allocation, and further create greater trading space for agriultural water rights. Agricultural water rights involve multi-level management systems, but few studies have analyzed the factors affecting the development of agricultural water rights trading from different dimensions in detail, so it is impossible to systematically promote the development of agricultural water rights trading. Therefore, this paper divides the key factors affecting the development of agricultural water rights trading into three dimensions : macro social economy, middle market players and their mutual relations, and micro trading elements. A qualitative analysis is made of the substantive attributes of each factor index in different dimensions and its impact on the development of agricultural water rights trading, and the macro-support for the development of agricultural water rights trading is found. This paper clarifies the development ideas of agricultural water rights trading market, and then focus on the role of micro-trading elements in the process of water rights trading. From three dimensions, it puts forward suggestions on how to strengthen the agricultural water rights trading policy and promote the construction of rural water system connectivity in multiple ways, clarify the role positioning of government and enterprises, and encourage the synchronous transfer of agricultural water rights trading and land to activate the agricultural water rights trading market so as to improve the agricultural water rights trading market to provide the construction foundation and ideas. [ABSTRACT FROM AUTHOR]

For deep and large pits composed of different shapes, the excavation sequence significantly influences the deformation of the foundation pit and its supporting structures. To minimize the impact of different excavation sequences on construction stability and determine the optimal sequence, numerical simulations are conducted using finite element software based on the Fuzhou Metro Foochow Arsenal Station excavation project. Circular and rectangular sections are considered, and various excavation sequences are simulated. The following conclusions are drawn: (1) For small-span pits, excavating the rectangular section first and then the circular section results in larger surface settlements compared to excavating the circular section first, whereas for circular and large-span pits, excavating the rectangular section first and then the circular section is more favorable. (2) Excavating the rectangular section first and then the circular section leads to smaller maximum horizontal displacements of the sidewalls compared to the reverse sequence. (3) For the circular section, cut and cover excavation is superior to open cut excavation, and preserving the core soil during excavation is the optimal method. In summary, excavating the rectangular section first and then the circular section, with the circular section excavated using cut and cover excavation while preserving the core soil, represents the optimal approach. [ABSTRACT FROM AUTHOR]

In this paper, gahnite (ZnAl2 O4) was prepared with solid phase reaction by ZnO and Al2 O3 as raw materials. The micro-structure change of ZnAl2 O4 was researched when ZnO/Al2 O3 molar ratios were 1.0 : 0. 9, 1.0 : 1.0 and 1.0: 1.1, respectively. In addition, the effect of ZnAl2 O4 on properties of high alumina castables were studied. The results show that when the molar ratio of ZnO to Al2 O3 is 1.0: 0.9, due to the excessive ZnO, it volatilizes because of the removal of O2- to produce liquid phase, and the surface of ZnAl2 O4 particles is microporous structure. When the molar ratio of ZnO and Al2 O3 is 1.0: 1.0 (standard molar ratio), the surface of ZnAl2 O4 particles with standard molar ratio is smooth. The lattice strain value (0.085 86) of standard molar ratio ZnAl2 O4 is the smallest, which can capture more manganese ions and iron ions in steel slag. When the molar ratio of ZnO to Al2 O3 is 1.0: 1.1, the surface of ZnAl2 O4 particles is rough. The high alumina castable with standard molar ratio ZnAl2 O4 has denser structure, highest strength and best slag resistance. [ABSTRACT FROM AUTHOR]

Using pentamethylene diisocyanate from biomass as the research object, a low viscosity polyisocyanate composition containing ureadione is synthesized by tricyclopentylphosphine catalyst. The composition was further modified hydrophilically by non-ionic modification method, thus an aqueous dispersible bio-based polyisocyanate curing agent is prepared. The effects of synthesis temperature, catalyst dosage and hydrophilic modification on the appearance, viscosity and aqueous dispersibility of the curing agent are investigated. The structural characteristics of the curing agent are characterized by gel permeation chromatograph. The results show that the bio-based PDI curing agent containing ureadione has the advantages of good aqueous dispersibility, high gloss, high hardness, strong adhesion and good flexibility. [ABSTRACT FROM AUTHOR]

Objective To study the clinical characteristics and prognosis of SARS-CoV-2 Omicron variant infection-associated acute necrotizing encephalopathy (ANE) in children. Methods A retrospective analysis was conducted on the medical data of 12 children with SARS-CoV-2 Omicron variant infection-associated ANE who were admitted to the Pediatric Intensive Care Unit, Qingdao Women and Children's Hospital from December 18 to 29, 2022. The children were divided into two groups based on outcomes: death group (7 cases) and survival group (5 cases). The clinical manifestations and auxiliary examination results were compared between the two groups. Results The median age of the 12 patients was 30 months, with a male-to-female ratio of 1:1. All patients presented with persistent high fever, with a median highest body temperature of 41 °C . The median time from fever onset to seizure or consciousness disturbance was 18 hours. The death group had a higher proportion of neurogenic shock, coagulation dysfunction, as well as elevated lactate, D-dimer, interleukin-6, interleukin--8, and interleukin-10 levels compared to the survival group (P<0.05). Conclusions Children with SARS-CoV-2 Omicron variant infection-associated with ANE commonly present with persistent high fever, rapidly progressing disease, and have a high likelihood of developing consciousness disorders and multiorgan dysfunction within a short period. The occurrence of neurogenic shock, coagulation dysfunction, and significantly elevated cytokine levels suggests an increased risk of mortality. [ABSTRACT FROM AUTHOR]

The electromagnetic wave absorption capabilities of conventional iron matrix composites and ceramic matrix composites are constrained by factors such as their high density, poor absorption efficiency, restricted absorption bandwidth, and other drawbacks. The low density and strong electrical conductivity of carbon-based composites have made them a wave-absorbing material of significant interest in recent years. Among them, carbon fiber reinforced composites (CFRP) have the potential for research and development in microwave absorption performance, and as a light weight, high strength, high stiffness and high temperature resistance material, they have unique advantages in the field of wave absorbing materials. The mechanism of absorbing materials and the mechanism of electromagnetic wave loss are introduced, and the research progress of absorbing modification of CFRP in recent years is reviewed. The wave absorption modification is mainly divided into two categories. One is to introduce special substances and structures into the material matrix, including magnetic metal modification, nano modification and surface structure modification. The other is to treat the material's surface with coatings, including composite coating and gradient coating. The development trend of CFRP wave absorbing composites is prospected. [ABSTRACT FROM AUTHOR]

BackgroundIt is a new trend to use X-ray sources instead of 137Cs γ-ray source in density logging.PurposeThis study aims to investigate the effect of X-ray tube high-voltage on the density measurement accuracy in the well logging.MethodsFirstly, Monte Carlo (MC) simulation was used to study the X-ray tube high-voltage dependence of the energy and intensity of X-rays. Then, the relationship between the high-voltage and the count rate of X-rays as well as its statistical error was analyzed. Thereafter, the density logging response of formations with various densities was simulated by MC, and effects of the high-voltages on the accuracy of density measurements were calculated. Finally, the high-voltage range suitable for the X-ray density logging was obtained.ResultsResults from MC show that the relative standard deviation of the count rates decreases with the increase of X-ray tube high-voltages. The accuracy of the density measurements reach 0.01 g·cm-3 when the high-voltage is 340 kV.ConclusionThis study provides a theoretical basis for the selection of X-ray tube high-voltages in the X-ray density logging and the design of well-logging schemes.

Tertiary amine organic macromolecule cationic ffocculant" D-PAM) was synthesized by grafting diethylamine onto polyacrylamide ( PAM ) based on Mannich reaction and used for high turbidity water treatment. The optimal conditions for preparing D-PAM ffocculant and treating high turbidity wastewater were determined by comparing different raw material feed ratios, pH values, reaction time, and reaction temperatures. The results showed that when the molar ratio of PAMu formaldehyde: diethylamine = 1u 0. 7: 0. 85,pH = 9 - 11, reaction temperature 45 - 50 °C, formaldehyde reaction time G1 = 1 h, diethylamine reaction time G2 =2 h,the grafting effect was the best. At the same time,the ffocculant has good treatment effect on high turbidity wastewater. The optimal ffocculation condition is to use 0. 7 mL of 1 D-PAM solution under strong acid or alkali conditions,quickly stir at 300 r/min for 4 min,then stir at 180 r/min for 7 min, settle for 20 min, and achieve a maximum turbidity removal rate of 99. 81 . The synthesized ffocculant can be used for the treatment of high turbidity wastewater and oily wastewater simultaneously, obtaining a new type of cationic ffocculant that can treat wastewater with dual functions. [ABSTRACT FROM AUTHOR]

To study the effect of the microcrack damage accumulation on ignition behavior of PBXs under low-velocity impact, the mechanical-thermal-chemical coupled model of PBXs considered the asymmetric evolution of microcrack under tension and compression, was used to simulate the ignition behavior of HMX-based PBXs with damage accumulation. The damage accumulation was generated by multiple impact. In addition, the ignition behavior of PBXs under multiple impacts of flat and pin projectiles was simulated. The calculation results showed that with damage accumulation, the ignition threshold of PBXs under the second impact nonlinearly decreased as the first impact velocity increased. It was becasue that multiple impacts increased the damage degree of cracks which propagated circumferentially in the impact area, and the accumulation of circumferential cracks strengthened the shear deformation of PBXs, which leaded to the generation of frictional heat between the surface of cracks, and hotspots formed. The damage degree of PBXs increased around the edge of the projectile under impacts of the flat projectile, and ignition occurred at the same position. Under multiple impacts of pin projectile, the crack damage significantly increased, which also leaded to the ignition of PBXs. [ABSTRACT FROM AUTHOR]

Taking recycled concrete as the research object, fly ash was selected to replace cement. By adjusting the proportion of fly ash, high performance fly ash recycled concrete with different replacement rates (0, 10%, 30%, 50% and 70%) was prepared. The effects of different replacement rates of fly ash on the micro morphology, mechanical properties, flexural toughness and frost resistance of recycled concrete were studied. The results showed that there wasn't new hydration product after adding fly ash, but the hydration reaction rate was accelerated, the diffraction peak strength of Ca(OH)2 was increased, and the fly ash particles were more closely combined with the hydration product gel, which enhanced the compactness of recycled concrete. When the re-placement rate of fly ash was 50%, the structure of recycled concrete was the most dense. With the increase of replacement rate of fly ash. the compressive strength and flexural strength of recycled concrete increased first and then decreased. When the replacement rate of fly ash was 50%, the compressive strength and flexural strength at 28 d reached the maximum value, 44.2 and 5.96 MPa, respectively, and the deflection reached the maximum value of 7.7 mm, with the strongest deformation resistance. With the increase of freeze-thaw cycles, the surface peeling phenomenon of recycled concrete intensified. With the increase of replacement rate of fly ash, the mass loss of recycled concrete decreased first and then increased, and the relative dynamic elastic modulus increased first and then decreased. When the freeze-thaw cycle was TOO times and the replacement rate of fly ash was 50%, the minimum mass loss rate of recycled concrete was -0.09%, the maximum relative dynamic modulus of elasticity was 94.52%, and the frost resistance was the best. [ABSTRACT FROM AUTHOR]

Nitrogen (N) and silicon (Si) are important nutritional elements for rice. However, excessive N fertilizer application and the ignorance of Si fertilizer are common in practice. Straw biochar is rich in Si, which can be used as a potential Si fertilizer. In this study, we conducted a consecutive 3-year field experiment to explore the effects of N fertilizer reduction combined with straw biochar application on rice yield, Si and N nutrition. There were five treatments: conventional N application (180 kg ⋅ hm², N100), 20% N reduction (N80), 20% N reduction with 15 t ⋅ hm² biochar (N80+BC), 40% N reduction (N60), and 40% N reduction with 15 t ⋅ hm² biochar ( N60+BC). The results showed that compared with N100, 20% N reduction did not affect the accumulation of Si and N in rice; 40% N reduction reduced foliar N absorption, but significantly increased foliar Si concentration by 14.0%-18.8%; while combined application of biochar significantly increased foliar Si accumulation, with an increase of Si concentration by 38.0%-63.3% and Si absorption by 32.3%-49.9%, but further reduced foliar N concentration. There was a significant negative correlation between Si and N concentration in mature rice leaves, but no correlation between Si and N absorption. Compared with N100, N reduction or combined application of bio- char did not affect soil ammonium N and nitrate N, but increased soil pH. Nitrogen reduction combined application of biochar significantly increased soil organic matter by 28.8%-41.9% and available Si content by 21.1%-26.9%, with a significant positive correlation between them. Compared with N100, 40% N reduction reduced rice yield and grain setting rate, while 20% N reduction and combined application of biochar did not influence rice yield and yield components. In summary, appropriate N reduction and combined with straw biochar can not only reduce N fertilizer input, but also improve soil fertility and Si supply, which is a promising fertilization method in double-cropping rice fields. [ABSTRACT FROM AUTHOR]

The study was to explore the effect of different additives on nutritional value and microbial community of whole plant quinoa silage. Four varieties (lines) of quinoa were selected in experiment, including purplish red, SC-1, ZK-1 and ZK-5. The quinoa silage was made by adding lactic acid bacteria (0.05 g/kg), cellulase (0.5 g/kg) and formic acid (4 mL/kg). Direct silage was used as control group (CK). Quinoa silage for 60 d, the change of nutrient composition and the number of microorganism in quinoa were determined. The results showed that the sensory evaluation grade of additive silage of the four quinoa varieties (lines) was Grade I (excellent), and the quinoa silage made with lactic acid bacteria and formic acid as additives had the highest score. The dry matter content of quinoa silage prepared with three additives was significantly higher than that in control group ( P<0.05), and NDF content of SC-1 and ZK-1 quinoa silage in cellulase group was significantly lower than that in control group ( P<0.05). The content of ADF in four varieties quinoa silage in cellulase group were significantly lower than those in control group ( P<0.05), and the content of WSC in four varieties quinoa silage in cellulase group were higher than those in control group ( P<0.05). After quinoa silage, the content of lactic acid bacteria was 1.2×104~1.3×106 CFU/g, the number of yeast and mold colonies was less than 10² CFU/g, and pH value was between 3.56 and 3.9.The study indicates that the addition of lactic acid bacteria, cellulase, formic acid to quinoa silage can improve the quality of quinoa silage. [ABSTRACT FROM AUTHOR]

Weighted Gene Co-expression Network Analysis (WGCNA) is a classic systems biology analysis method, which can be used to identify coexpressed gene modules and explore the biological correlation between modules and target traits, and mine core genes in module networks. In this study, 58 transcriptome data of roots, stems, leaves, and other tissues under low temperature stress, high temperature stress, drought stress, and salt stress in maize (Zea mays L.) were collected, and the gene co-expression network of maize abiotic stress was identified by WGCNA method. After filtering the 12,552 low-expression genes from transcriptome data, the co-expression network was constructed using the remaining 27,204 high-expression genes, and 25 modules were obtained. According to the distribution of abiotic stress-related genes and different expression genes in the modules reported in maize, the mediumpurple4, ivory, coral2, darkseagreen4 modules most related to low temperature stress, high temperature stress, drought and salt stresses, and green modules responding to various stresses were screened out. Subsequently, GO enrichment of the genes in these five modules revealed that genes with functions related to abiotic stress were significantly enriched in these modules, such as stress response, peroxidase activity. Correlation analysis showed that 10 abiotic stress-related core genes were predicted, including Zm00001eb072870, Zm00001eb320970, Zm00001eb037640, Zm00001eb423300, and Zm00001eb265310. This study provides new ideas for the mining of abiotic stress-related genes and the research of abiotic stress regulatory networks in maize. [ABSTRACT FROM AUTHOR]

The design and synthesis of photocatalytic materials and their application in environmental pollution control and resource recycling have been reported in many literatures. However, most photocatalytic materials contain transition metal ions, and the environmental risks of leaching 1imit the application of catalytic materials. Silicon carbide (SiC), as the representative of the third generation of semiconductor materials, has a good potential application prospect in environmental pollution prevention because of Is characteristics such as no transition metal ions, high temperature and acid-alkali resistance, strong stability and so on. In recent years, some literatures have reported the synthesis, modification and application of SiC as photocatalyst n environment and resource recycling -fields. However, few temperatures have reviewed the application progress of SiC photocatalyst. In view of the above situation, the progress in the -field of SiC photocatalysis application in recent years was reviewed in tins paper, including synthesis method, doping medication and application, and the prospects of the photocatalyst system were also prospected. [ABSTRACT FROM AUTHOR]