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The interaction propagations between multiple pathogens can change propagation threshold and steady-state density of each other. This provides a new thinking of the virus immune method. This paper developed an interaction spread model between viruses and immune agents using compartment theory on the double coupling networks and proposed the evaluation indexes of immune effect. The immune agents could spread in host group just as the viruses do. Each node infected by immune agents would be free from viruses and propagate immune agents to its neighbor nodes with some probability. Viruses and immune agents may spread in the same host group but different transmission pathway. Simulation experiments show that immune transmissions reduce significantly the range and speed of virus transmissions on the synthetic networks and real networks. There are ideal immune parameters with low resource consumption and highly immune effect. The spread method of immunization a-gents can bring obviously immune effects on the virus prevention. [ABSTRACT FROM AUTHOR]