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Objective To explore the applied value of thyroid imaging reporting and data system (TI-RADS) stratification in diagnosing thyroid nodules in patients with different ages. Methods A total of 527 patients with thyroid nodules (aged 26-65) were divided into four groups: aged 26-35 group, aged 36- 45 group, aged 46-55 group and aged 56-65 group. TI-RADS was used to evaluate patients in four groups. The results of TI-RADS were compared with the pathologic diagnostic analysis. Results For the low aged groups (aged 26-35 group and aged 36-45 group), the positive predictive value, the negative predictive value and accuracy rate were more than 90%. With regard to the patients aged 46-55, the positive and negative predictive values and accuracy rate were 81.5%, 87.5%, and 81.9%, respectively. The positive and negative predictive values, accuracy rate were 76.6%, 88.8% and 77.9% for patients aged 56-65 group. The diagnostic rate of TIRADS in patients with thyroid lesions was lower in aged 56-65 group than that of other groups. Conclusion TI-RADS method is affected by age. The diagnostic rate is lower in the high age group than that of the low age group. [ABSTRACT FROM AUTHOR]