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BackgroundWhen the suspended dipole field coils experience significant disturbances during the operation of the suspended dipole field device, the Tilt-Slide-Rotate (TSR) coils are used to control the attitude of the dipole field coils, thereby preventing them from losing control.PurposeThis study aims at attitude control of dipole fields by coil forces of the TSR coils with relatively complex geometric structures.MethodsBased on the line segment approximation method, the modeling and analysis were conducted for scenarios where the dipole field coils return to their balanced position under conditions of dipole field tilt and offset by controlling the magnetic forces generated by the TSR coils on both opposite and same sides. The coupling magnetic field between the TSR coils and the dipole field coils was calculated, and the magnetic field line structure was analyzed. The excitation magnetic field of the TSR coils, in the form of sinusoidal currents, was simulated to induce azimuthal magnetic disturbances. Analysis was performed on the magnetic field line structure and phase of the perturbation magnetic field on the Poincaré section at the equatorial plane. [Results and Conclusions] If only one group of TSR coils on the same or opposite sides is used to control the dipole field coils to restore equilibrium, exhibited mechanical instability needs necessitating coordinated control by multiple sets of TSR coils. Applying pseudo-sinusoidal currents to all TSR coils induces compression and stretching effects on the background dipole magnetic field. By controlling the current of the TSR coils to control the phase of the compression position, the feasibility of controlling the attitude of the dipole field coils with multiple TSR coils has been validated. However, this process may also cause drift in the background magnetic field and the formation of open magnetic field lines, which could drive plasma instabilities and lead to particle loss.

Network security has become a major issue related to national security and development and the vital interests of the people. The network security situation is also becoming increasingly severe. Network attacks endanger political security, social stability, economic development and cultural construction. International competition in cyberspace is in the ascendant. This system identifies and warns potential network risks from multiple dimensions, takes effective measures to block the attack before the attack is successful, which can ensure the stable operation of the information system.

In the face of complex forms of network security, attackers often use a large number of information investigation, vulnerability utilization and confusion technologies to carry out malicious activities or destruction in the network. Although the current network security situational awareness platform finds and monitors the utilization process of new vulnerabilities as much as possible, the accuracy of attack prediction are not satisfactory. It is necessary to study more advanced algorithms based on the current prediction technology to automatically associate security events with the corresponding assets and attack types, carry out early warning and risk assessment for possible network security attacks to achieve accurate prediction of network security events.

Autosomal recessive congenital ichthyosis (ARCI) is a rare hereditary cornification disorder presented with abnormal skin scaling. In this paper, we used next-generation sequencing to determine the variants in a Chinese ARCI patient. We used sanger sequencing to verify bidirectionally the DNA from the proband and her parents. Results showes that two compound heterozygous variants (c.235G > T and c.641delG) in CYP4F22 gene, and both of the mutations are novel. The parents were heterozygous carriers. The two variants are classified as pathogenic variants based on interpretation guidelines. The compound heterozygous mutations in CYP4F22 gene were the causative mutations responsible for ARCI in proband.

Light-induced greening of tubers seriously affects its safety and economic benefits, but the mechanism of light-induced chlorophyll synthesis in potato tubers remains unclear. In this study, the related metabolites of potato tubers with different light durations were analyzed. The results were as follows: When the light duration prolonged, the chlorophyll content of the tubers gradually increased. Moreover, the chlorophyll content increased significantly at 36 hours, with which the tuber skin turned green obviously. Transcriptome sequencing and bioinformatics analysis were carried out on the samples taken at 0 hour, 6 hours, and 36 hours, and 5646 differentially expressed genes (DEGs) were identified. According to the co-expression cluster analysis and quantitative RT-PCR verification results, 9 major structure genes of chlorophyll biosynthesis pathway (StGAS1, StCHLD, StCrd1, StHEMA, StGUN4, StPORA, StUROD, StCHLM, and StCHLG) and 6 transcription factors (StSBP, StLSD, StGATA, StWRKY, StMYB-like, and StMYB113) were significant induced. Predictions of the cis-acting elements of the promoter sequences of these 9 structural genes indicated that they all contained multiple MYB binding sites. Promoter element analysis and transcriptional activation validation further revealed that StMYB113 had a light-responsive element and could activate the expression of StUROD in tobacco. Therefore, StMYB113 may be light-responsive and be able to regulate potato tuber greening in the light. This study provides a reference for the research on the regulatory mechanism of light-induced chlorophyll synthesis in potato tubers, which is important for reducing the loss caused by greening of potato tubers. [ABSTRACT FROM AUTHOR]