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Objective To explore the application of ROADMAP function in endovascular sclerotherapy of venous malformations guided by digital subtraction angiography (DSA). Methods From May 2019 to July 2020, 11 patients underwent endovascular sclerotherapy of venous malformations guided by DSA. The ROADMAP function was used to monitor the administration of sclerosant in real time during the operation. Postoperative follow-up and efficacy evaluation were performed. Results Eleven patients received sclerotherapy of 25 times for 13 lesions, with an average of (2.1±0.9) times. The average treatment period was (18.5±3.4) min, and the average use period of the ROADMAP function was (52.5±10.3) s. All patients were followed up for 24 months. Seven cases had complete response, 2 cases had significant response and 2 cases had partial response. No recurrence or progression was found. No serious complications such as bleeding, ulceration, infection or dysfunction occurred in all patients. Conclusion The ROADMAP function can improve the safety of treatment, grasp the structure of lesion, make the drug dose more accurate and does not significantly increase the operative duration. It should be considerable for clinical application. [ABSTRACT FROM AUTHOR]