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Teaching medicinal chemistry in English plays a crucial role in cultivating international and innovative pharmaceutical talents. This study, based on the practical work of teaching medicinal chemistry in English, identified the pain points of this practice, such as limited and abstract teaching content and the limited teachers' level. Moreover, adhering to the concept of "student-centered and international-oriented" teaching, this study entailed an innovative practice research on teaching medicinal chemistry in English from the perspectives of teaching staff, teaching content, and teaching methods. It was revealed that, to improve the quality of teaching, this practice should focus on an innovative international teaching system based on the following four aspects: teaching team building, teaching methods, curriculum system, and teaching materials. [ABSTRACT FROM AUTHOR]

Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors of the head and neck region. NPC has the characteristics of insidious onset, strong invasiveness and early lymph node metastasis. A variety of signaling pathways play a role in the invasion and metastasis of nasopharyngeal carcinoma, but the specific mechanism has not yet been fully elucidated. Recent studies have found that DNA methylation of nasopharyngeal carcinoma-related genes can affect the invasion and metastasis of nasopharyngeal carcinoma through a variety of signaling pathways including Wnt/β-catenin, PI3K/AKT and MAPK signaling pathways. This article reviews the specific mechanism of DNA methylation affecting the invasion and metastasis of nasopharyngeal carcinoma through the above-mentioned signaling pathways.

Background Colorectal cancer has become the third most prevalent malignant tumor in Jiading district of Shanghai, and its disease burden is still increasing. Objective To analyze the epidemic trend of colorectal cancer in Jiading district of Shanghai from 2003 to 2019 and provide scientific basis for the prevention and treatment of colorectal cancer. Methods Based on the cancer registration data from 2003 to 2019 in Jiading district of Shanghai, the statistical indicators such as crude incidence rate, crude mortality rate, standardized incidence rate and standardized mortality rate were calculated (the rate was standardized using the Chinese standard population of 2010). Joinpoint Regression Program 4.9.1.0 software was used to analyze the trends of incidence rate and mortality rate. Results From 2003 to 2019, there were 5 020 new cases of colorectal cancer in Jiading district of Shanghai, with a crude incidence rate of 52.12/100 000, a standardized incidence rate of 26.27/100 000; there were 2 419 deaths, with a crude mortality rate of 25.12/100 000, and a standardized mortality rate of 11.16/100 000; with males having higher crude incidence and crude mortality rates than females (P

Objective To explore the pathogenesis, diagnosis and treatment of syndrome of inappropriate secretion of antidiuretic hormone （SIADH） caused by sodium valproate （VPA）, aiming to improve the awareness of clinicians. Methods Clinical data of a patient with SIADH caused by long-term use of VPA were collected. Literature review was conducted by using the keywords of “VPA” and “SIADH” in both Chinese and English from PubMed and CNKI databases. Results The 62-year-old male patient presented with malaise, lower extremity edema, and hyponatremia as the main manifestations. He was administered with VPA for a long-time due to the secondary epilepsy. The diagnosis of SIADH caused by VPA was confirmed after excluding other possible causes of hyponatremia. After stopping VPA and adding tolvaptanka, serum sodium gradually returned to normal range. During follow-up, the patient’s symptoms were improved, and the serum sodium was normal. Through literature reviews, a total of 5 related case reports consisting of 8 patients were retrieved and 6 of them were middle-aged and elderly patients. Symptoms of all patients were improved after gradually discontinuing use of VPA. Conclusions The cases of SIADH caused by use of VPA have been rarely reported in clinical practice, which are likely to be missed diagnosis or misdiagnosed. This case prompts that when SIADH is considered in the diagnosis of refractory hyponatremia, attention should be paid to the possibility that SIADH may be caused by use of VPA. Hence, the treatment plan should be timely adjusted to mitigate symptoms and enhance prognosis of patients.