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Objective To investigate the clinical characteristics, diagnosis and treatment of severe combined periodontal-endodontic lesions in a double-rooted maxillary lateral incisor with a palatal radicular groove and to provide a reference for clinical diagnosis and treatment. Methods A patient with a double-rooted left maxillary lateral incisor with a palatal radicular groove and severe combined periodontal-endodontic lesions underwent complete root canal therapy and intentional replantation, and a retrospective analysis of the management of this type of patient was performed based on the literature. Results The 3-year follow-up examination revealed no discomfort, good healing of the upper left lateral incisor, no pathological loosening, and a palatal gingival sulcus was found at a depth of approximately 1 mm. Review of the literature showed that the prognosis of the affected tooth and the choice of treatment plan were correlated with the length and depth of extension of the lingual groove toward the root, the periodontal condition and the pulpal status of the affected tooth. For minor PRGs or for affected teeth with no loss of pulpal viability, flap surgery and odontoplasty can be used to avoid endodontic treatment or retreatment. For deep or long lingual grooves that result in significant loss of periodontal tissue, endodontic treatment, odontoplasty, or closure of the grooves and guided tissue regeneration are needed. In the case of PRGs with double root formation, the affected tooth can be preserved via root canal therapy, removal of the small root and filling with apical restorative material, and intentional replantation. Conclusion In cases of severe combined periodontal-endodontic lesions due to palatal radicular grooves occurring in double-rooted maxillary lateral incisors, clinical presentation and imaging can prevent missed diagnoses, and appropriate treatment should be based on the length and depth of lingual grooves extending toward the roots, periodontal conditions, and pulpal status of the affected teeth.

Objective To analyze the clinical,CT and MRI characteristics of tuberous sclerosis complex (TSC) to raise awareness of multiple organ damage in this disease. Methods The clinical, CT and MRI characteristics of 12 cases of clinically confirmed TSC in Nanjing Jiangbei Hospital from September 2015 to June 2020 were retrospectively analyzed. Results TSC involved multiple organs and showed different changes in clinical imaging (the count of cases may overlap). In central nervous system, there were 9 cases of typical subependymal nodule, including 7 calcified nodules and 2 non-calcified nodules; 5 cases of cortical and subcortical nodule, 3 cases of white matter signal change, 1 case of subependymal giant cell astrocytoma. In abdomen,there were 8 cases of angiomyolipoma of different sizes in both kidneys (of which 2 cases were accompanied by intratumoral hemorrhage) and 1 case of multiple hepatic angiomyolipoma. In chest, there were 2 cases of pulmonary lymphangioleiomyomatosis and 1 case of cardiac rhabdomyoma. In bone, there was 1 case of multiple nodular and patchy osteosclerosis. Conclusion The analysis of clinical imaging features of TSC multi-system tumor is helpful for the diagnosis of TSC.

As a physical carrier of energy Internet， integrated energy system can improve energy utilization efficiency. Therefore， its optimal dispatching has attracted extensive attention of scholars all over the world. Firstly， the comprehensive demand response and the operation model of multi-energy storage device are modeled； Then， the minimum total operation cost of the integrated energy system is taken as the objective function to construct the optimal dispatching model of the integrated energy system considering the comprehensive demand response and multi-energy storage devices； Then， the CVaR （conditional value at risk） is used to deal with the output uncertainty of renewable energy； Finally， an example of an electric-heat-cold integrated energy system is analyzed. The results show that the model proposed in this paper can reduce the operation cost of the integrated energy system and measure the operational risk caused by output uncertainty of renewable energy.

BackgroundSolid oxide cell (SOC) is the core converter for hydrogen production by high temperature electrolysis of water vapor and hydrogen fuel utilization.PurposeThis study aims to develope two kinds of aqueous casting pastes of NiO-YSZ with different components for the batch preparation of SOC without the usage of a large number of organic solvents.MethodsA 10 cm×10 cm large-scale full-scale cell was prepared by screen printing the hydrogen electrode functional layer, electrolyte layer, barrier layer and oxygen electrode layer with NiO-YSZ support film at one time casting of about 450 μm. The effect of dispersant on the microstructure of hydrogen electrode support and the stability of the pastes were analyzed by scanning electron microscope (SEM). The performance of the SOCs were tested by I-V curve and electrochemical impedance.ResultsBased on the optimized NiO-YSZ supports, the prepared planar SOCs delivers a peak power density of 0.36 W·cm-2 at 750 ℃. The electrolysis current density of SOC can reach -0.68 A·cm-2 at 1.30 V in solid oxide electrolysis cell (SOEC) model.ConclusionsThe performances of the aqueous-based SOCs can be considered highly remarkable, thus supporting the success in scaling the fabrication of SOCs using more environ-mentally friendly processes than conventional ones.

Objective: To translate the University of Rhode Island Change Assessment of voice scale（URICA-Voice） into Chinese and test its reliability and validity. Methods: The URICA-Voice scale was converted into Chinese by literal translation, cultural adjustment, expert consultation, pre-investigation, and back translation. Convenience sampling was used to recruit patients at four speech therapy centers from February to May 2022. Then the Chinese version of the scale was distributed to them, and the reliability and validity of the scale were tested after data collection. Cronbach ɑ was used to evaluate the reliability. The critical ratio method and Pearson correlation coefficient were used for item analysis. Item-level content validity, scale-level content validity, and confirmatory factor analysis were used to test the validity of the scale. Results: A total of 247 valid questionnaires were collected. ①Item analysis: the critical ratios between a high-score and low-score groups of 32 items were all statistically significant（ P <0.01） and all the critical ratios were above 3.00. The Pearson correlation between 32 items and the total score was significant（ P <0.01）. ②Validity analysis: I-CVI=1.00, S-CVI/ Ave =1.00, χ²/df =2.30, RMSEA =0.07. Except for item 9 and 23, the standardized factor loading coefficients of other items were all above 0.50. AVE of the four dimensions of the scale was all above 0.50, and the combined reliability of the four dimensions was all above 0.70. The correlation coefficients between dimensions were less than the square root of the AVE of the dimension itself. ③Reliability analysis: the Cronbach ɑ of the whole scale was 0.94, and the Cronbach ɑ of the four dimensions were 0.88, 0.92, 0.94, and 0.88 respectively. Conclusion: The Chinese version of URICA-Voice has good reliability and validity, and can be used as a specific measurement tool for evaluating the compliance of voice training in China., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.)

Due to the COVID-19 pandemic, the teaching of Biopharmaceutical Engineering course was carried out online and completed with satisfactory outcomes. In order to improve the efficiency of online teaching, ensure the substantive equivalence between online and offline teaching and achieve effective teaching, this article summarized the exploration and practical experience of online teaching, taking the Biopharmaceutical Engineering course as an example. This includes analysis of learner characteristics, selection of online teaching platform, development of teaching resources, optimization of teaching contents, BOPPPS teaching method-based design of teaching structure, and reflection of effective teaching. This paper is expected to provide a useful reference for online teaching.

Objective: This study investigated the application of combined ossicular replacement prosthesis（The Kurz Omega Connector+TORP） in type Ⅲ tympanoplasty, and compared the surgical effect with traditional TORP. Methods: Twenty patients with unilateral chronic suppurative otitis media diagnosed in the Department of Otorhinolaryngology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University from January 2019 to June 2020 were included in this study.All the patients were treated with intra-auricular incision with a microscopic approach（tympanic exploration, lesion clearance+type Ⅲ tympanoplasty）. According to the placement of different types of ossicular replacement prosthesis in the ossicular chain reconstruction of type Ⅲ tympanoplasty, the patients were divided into two groups: the traditional TORP group（ n =10） and the combined ossicular replacement prosthesis（The Kurz Omega Connector+TORP） group（ n =10）. All patients underwent pure tone audiometry before and 1 year after the operation, and the average hearing threshold and air-bone conduction difference（ABG） were compared between the two groups before and after the operation. Results: The reconstruction of the ossicular chain was completed successfully in all patients. Endoscopic examination showed that the epithelialization of the operative cavity was good and the repair of the tympanic membrane recovered well one month after the operation. There was no significant difference in preoperative mean airway threshold between the combined ossicular replacement prosthesis and the traditional TORP group （74.13[41.50，80.50] dB vs 74.25[44.81，82.50] dB, P >0.05）, there was no significant difference in preoperative ABG （55.63[21.50，61.25] dB vs 54.13[23.63，60.38] dB, P >0.05）. After the operation, the ABG of the combined auriculus group was significantly lower than that of the traditional operation group （12.00[5.75，24.56] dB vs 34.88[14.19，46.44] dB, P <0.05）. Conclusion: The combined ossicular replacement prosthesis（The Kurz Omega Connector+TORP） can increase the stability of hearing reconstruction and improve hearing in type Ⅲ tympanoplasty., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.)

Breathing pattern parameters refer to the characteristic pattern parameters of respiratory movements, including the breathing amplitude and cycle, chest and abdomen contribution, coordination, etc. It is of great importance to analyze the breathing pattern parameters quantificationally when exploring the pathophysiological variations of breathing and providing instructions on pulmonary rehabilitation training. Our study provided detailed method to quantify breathing pattern parameters including respiratory rate, inspiratory time, expiratory time, inspiratory time proportion, tidal volume, chest respiratory contribution ratio, thoracoabdominal phase difference and peak inspiratory flow. We also brought in "respiratory signal quality index" to deal with the quality evaluation and quantification analysis of long-term thoracic-abdominal respiratory movement signal recorded, and proposed the way of analyzing the variance of breathing pattern parameters. On this basis, we collected chest and abdomen respiratory movement signals in 23 chronic obstructive pulmonary disease (COPD) patients and 22 normal pulmonary function subjects under spontaneous state in a 15 minute-interval using portable cardio-pulmonary monitoring system. We then quantified subjects' breathing pattern parameters and variability. The results showed great difference between the COPD patients and the controls in terms of respiratory rate, inspiratory time, expiratory time, thoracoabdominal phase difference and peak inspiratory flow. COPD patients also showed greater variance of breathing pattern parameters than the controls, and unsynchronized thoracic-abdominal movements were even observed among several patients. Therefore, the quantification and analyzing method of breathing pattern parameters based on the portable cardiopulmonary parameters monitoring system might assist the diagnosis and assessment of respiratory system diseases and hopefully provide new parameters and indexes for monitoring the physical status of patients with cardiopulmonary disease.