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In the process of grain storage, the use of low-temperature grain storage technology can effectively reduce grain losses during storage and ensure grain quality, which is of great significance for maintaining a stable grain supply. Radiative cooling materials, as a new energy-free cooling technology, achieve cooling by radiating heat in the form of electromagnetic waves into outer space. This approach can address issues associated with traditional cooling methods, such as high energy consumption and high chemical oxygen demand (COD) emissions, offering a green and environmentally friendly new approach to low-temperature grain storage. This paper explained the working principle of polymer-based radiative cooling materials and systematically introduced the composition and selection criteria of polymer-based radiative cooling systems. It also categorized and summarized polymer-based radiative cooling materials according to their structural characteristics. The existing problems with different structured radiative cooling materials, as well as future research directions, were also analyzed. This provides a certain research framework for applying radiative cooling materials to grain storage facilities to achieve low-temperature grain storage.

Integrated energy systems enable the complementary utilization of various forms of energy. With the rapid increase in installed capacity of distributed generations, their intermittency and randomness have posed significant challenges to the operational efficiency and safety of the system. To address the impact of uncertainties in both energy supply and demand on the economic scheduling of building integrated energy systems, this study first models the operational characteristics of each subsystem, including the power grid, natural gas network, and various coupled equipments. Next, a thermal cell model of the building users is constructed based on the quantitative relationship among temperature, thermal radiation, and thermal load. Then, a day-ahead optimization scheduling model for the building integrated energy systems is established with the objective of minimizing the operating cost. A chance-constrained programming approach is employed to convert the non-linear scheduling model into a mixed-integer second-order cone programming problem easy to solve. Finally, simulation analysis is conducted in the Python environment using the CPLEX solver. The results demonstrate that the proposed model and solution method are capable of effectively characterizing and addressing uncertainty risks in the system, facilitating the consumption of renewable energy, and improving the economic efficiency of system operation.

The investigation and research of the distribution, biological characteristics, water environment and sediment environmental elements of the seagrass bed in Caofeidian was conducted to define the distribution area of the seagrass bed, classify its coverage, analyze and study the ecological characteristics of the seagrass bed and the characteristics of key environmental impact factors. This provides technical references for understanding the resource and environmental background of the Caofeidian seagrass bed, delimiting the protection area, marine ecological restoration, and blue carbon research. The results show that the dominant species of the Caofeidian seagrass bed is eelgrass, The average plant height is 75.00±6.15 cm/shoot. Moreover, there are differences among different sites. The overall average stem density is 261.26±48.50 shoots/m2, and the total average aboveground and belowground biomass are 302.53±71.79 g DW/m2 and 114.71±27.40 g DW/m2, respectively. The distribution area of the seagrass bed is 42.90 km2, with dense area, relatively dense area, general area, relatively sparse area and sparse area accounting for 13.09%, 12.93%, 18.82%, 18.75% and 36.40%, respectively. The seagrass is distributed in two regions, northern and southern, with dense area and relatively dense area mostly distributed in the northern region. The difference in water environment between the grass bed area and the bare sand area is not significant, while the difference in sediment environment between the grass bed area and the bare sand area is significant. Water temperature, nutrient salts, transparency, water flow, and human engineering activities are key factors that affect the growth of seagrass in the Caofeidian sea area.

Background Smart bracelets are increasingly used in chronic disease management, which help improve patient adherence and motivation to exercise interventions, but more evidence for their long-term effectiveness in patients with type 2 diabetes mellitus (T2DM) in the community needs to be explored. Objective To develop an intervention model for community-dwelling type 2 diabetes patients using smart bracelets, and to assess its long-term effectiveness in these patients. Methods From July to August 2018, this study selected 11 community health institutions from 11 districts of Guangzhou (one from each district) as study settings. And from each setting, 10-15 T2DM patients were selected (intervention group), and were compared to sex-matched and age-matched (+/- two years) T2DM patients (control group). The intervention was carried out from September 2018 to August 2019 in two groups, both received standardized health management services provided by the family physician team and underwent the exercise prescribed by an exercise prescriber. The intervention group additionally received health monitoring and management via wearing a smart bracelet, and set personalized exercise challenge goals under the guidance of an exercise prescriber. The score of the Chinese version of Summary of Diabetes Self-Care Activities Measure (SDSCA-C), comprehensive assessment indicators, and attainment rates of key glycemic indicators were compared between the two groups before and after the intervention. Results Ninety-two patients in the control group and 144 patients in the intervention group completed one-year intervention and follow-up. After the intervention, the subscale scores of dietary management and foot care management and the total score of SDSCA-C increased notably in the intervention group (P0.05). Two groups had no statistically significant differences in all comprehensive assessment indicators at baseline (P>0.05). After one year of intervention, besides a decrease was found in total cholesterol, apolipoprotein A1 and apolipoprotein B in both groups, a reduction was found in waist circumference in the intervention group, and in fasting plasma glucose (FPG), triacylglycerol and low-density lipoprotein cholesterol in the control group (P

Objective To screen and analyze the differentially-expressed genes （DEGs） of diabetic nephropathy （DN） by bioinformatics methods, aiming to explore the mechanism of IRF4 in DN, and to find potential molecular targets of DN. Methods The GSE142025 dataset was downloaded from the GEO database, including 9 cases in normal control group and 21 cases in advanced DN（aDN） group, and the DEGs were screened. The GSEA enrichment revealed the molecular biological process of the DEGs. Protein-protein interaction networks of DEG were visualized using String and Cytoscape software. The relative expression levels of major DEGs in six DN renal tissues （DN group） and six normal renal tissues after tumor resection （NC group） were verified using RT-qPCR, PAS and SP staining. Results GEO data analysis revealed 1213 differentially-expressed mRNA, of which 684 were up-regulated and 529 were down-regulated. The GSEA and KEGG pathway enrichment of DEGs showed that the DEGs in the DN group were significantly enriched in the JAK/STAT signaling pathway, chemokine signaling pathway, Fcγreceptor-mediated phagocytosis of macrophages signaling pathway, leukocyte transendothelial migration signaling pathway and T cell receptor signaling pathway. The relative expression levels of IRF4, signal lymphocyte activating molecule 6 and IL-2 receptor α subunit mRNA in the DN group were significantly higher compared with those in the NC group （all P < 0.001）. The PAS and SP staining results were consistent with those of RT-qPCR. Conclusion The GSEA enrichment pathways show that the inflammatory pathway is significantly active, and the expression of IRF4 as a hub gene is significantly up-regulated in the DN tissues, which may be involved in the highly-active inflammatory pathway and promote the progression of inflammation in DN.

The gold deposit in Xinjiang is located in the Kalamailimetallogenic subzone of the northern Junggarmetallogenic belt, with superior geological conditions for gold mineralization. The primary ore is difficult to separate due to its high carbon, arsenic and antimony contents and easy mudding. In the laboratory experiment, the primary ore is leached by granulationand the direct leaching rate is only 16.99%. However, by adopting flotation concentrate- roasting-cyanidation process, a total gold recovery of 73.14% is achieved. The study results show that the combined beneficiation and metallurgy process can make the gold mine reach a higher beneficiation and metallurgy index at areasonable cost.

Forward error correction (FEC) coding is a technique to cope with packet loss in network transmission.By adding redundant data to the transmission process,the receiver can recover the original data directly from the redundant data in packet loss scenarios.In the scenario of high packet loss and high latency,adding forward error correction coding appropriately can save a lot of waiting time for timeout retransmission to improve the quality of service of network transmission.Adding too much redundancy will result in bandwidth wasting,while insufficient redundancy will fail to recover lost data,so the difficulty of using forward error correction coding in practice is to properly control the proportion of redundant data.Nowadays,most of the forward error correction coding research is based on traditional network protocols,but with the rise of QUIC (quick UDP internet connections) protocol,more forward error correction researches start to incorporate QUIC protocol due to its characters like 0-RTT (round trip time) connectivity,multiplexing,seamless connection migration to further improve transmission performance.This paper gives an overview of forward error correction coding,introduces its application scenarios,basic policies and adaptive redundancy control strategies.Then it introduces the research status of forward error correcting coding in traditional protocols in unicast and multicast scenarios.Finally,this paper introduces the current research status and challenges of forward error correction coding in QUIC protocol.

In this paper, the TAW-1000 triaxial test system is used to carry out the triaxial compression test of the complete and single fractured coals under different confining pressures, and the acoustic emission monitoring system is used. This paper analyzes the failure mechanism of fractured coal and rock based on the fracture diagram of fractured coal and the relationship between stress and strain. The results show that: the stress of single fracture coal is more complex than that of intact coal. The stress concentration at the tip of the fracture leads to the formation of micro cracks and the development of connectivity, which makes the coal enter the plastic stage earlier and leads to the significant deterioration of the strength and elastic modulus of coal. The results show that the lateral deformation of fractured coal and rock is more significant than that of intact coal and rock under higher confining pressure; with the increase of confining pressure, the fracture mode of 45° fractured coal and rock presents an excessive failure mode from direct shear failure to oblique shear failure; the stress-strain curve of 60° fractured coal and rock presents a plateform softening, and the change of elastic modulus is not obvious with the increase of confining pressure; under the same confining pressure, with the increase of fracture angle, the mechanical parameters of fractured coal and rock deteriorate significantly with the increase of fracture degree. The fracture dip angle is positively correlated with the ringing number.

According to calculating ol the support strength when the repeated mining face passing through abandoned parallel gateway,a mechanical model for studying the principle of main roof fracture was established through spot investigation and analysis for fracture of roof of workface. Three factors such as the width of coal pillar between repeated mining face and abandoned parallel gateway, the distance between repeated mining face and main roof fracture line and the width of abandoned parallel roadways which may lead to the advanced fracture of main roof was put forward. Through the analysis of the three factors,the mechanical mechanism of advanced fracture of main roof was obtained. It shows that the coal pillars become destabilization when coal being extracted. The destabilization of the coal pillars leaves roof beam unsupported and increases the length of cantilever beam. When the length of cantilever beam is greater than or equal to cycle weighting interval, the cantilever beam breaks. Based on the Bieniawski formula, the critical width of coal pillar that becomes destabilization and the critical width of abandoned parallel gateway that main roof inevitably breaks in advance are calculated. The size of broken rock block of mechanical model of main roof weighting is adjusted on the basis of the mechanical model of main roof fracture. The adjustment is used to calculate the support strength of hydraulic support when repeated mining face passing through abandoned parallel gateway. It shows that the least support strength is 10 910. 77 kN. On-the-spot observation results show that the support strength is 9 656 kN when repeated mining face passing through abandoned parallel gateway. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of AICAR on the activity of transcription factor FOXO1 and expression of ubiquitin ligase MuRF1 in rat cardiomyocytes, and explore the possible role of AMP-activated protein kinase (AMPK) in proteolysis pathways., Methods: In vitro cultured neonatal rat cardiac myocytes were treated with AICAR, and Western blotting was used to detect the phosphorylation of FOXO1 and expression of MuRF1 in the cells., Results: AICAR activated AMPK in rat cardiac myocytes. Activated AMPK significantly inhibited the phosphorylation of FOXO1 and increased MuRF1 protein expression., Conclusion: AMPK may regulate proteolysis by activating FOXO1 transcription factor and up-regulating MuRF1 expression.

Objective: To study the effect of adenovirus (Ad)-mediated fusion gene system driven by the KDR promoter on the proliferation of human colon adenocarcinoma SW620 cells., Methods: The KDR-expressing SW620 cells and LS174T cells not expressing KDR were both infected with AdEasy-KDR-CDglyTK followed by treatment with the prodrugs 5-FC and/or ganciclovir at different concentrations. The effect of the transfection on the cell proliferation was evaluated., Results: The expression of green fluorescent protein (GFP) was observed in 95% of the infected SW620 and LS174T cells with a multiplicity of infection (MOI) of 100. Significant difference was not founded in the growth of SW620 and LS174T cells with or without the transfection. The infected SW620 cells exhibit high sensitivity to the prodrugs, but the infected LS174T cells did not (P<0.01). The CDglyTK fusion gene produced much stronger killing effect of on the target cells than either of the single suicide genes (P<0.01)., Conclusion: CDglyTK fusion gene system driven by the KDR promoter selectively kills the KDR-CDglyTK SW620 cells and inhibits the cell proliferation.

Objective: To study the expression and clinical significance of cytokeratin subtypes CK7 and CK20 and thyroid transcription factor-1 (TTF-1) in bronchioloalveolar carcinoma (BAC), and to investigate the value of these factors in identification of the prognosis of BAC., Methods: Eighty-one specimens of BAC resected during operation, 68 of non-mucinous type and 13 of mucinous type, underwent immunohistochemical examination to detect the expression of CK7, CK20, and TTF-1. The value of these 3 factors in the identification of the prognosis of BAC was examined by survival analysis., Results: All specimens showed positive expression of CK7, CK20, and TTF-1. There was no significant differences in CK7 expression rate among different ages, clinical stages, and pathological subtypes (all P > 0.05). Compared with that in the BAC of stage III and that of BAC of non-mucinous type, the CK20 positive rates of the BAC of stage I - II and mucinous type were both significantly higher (chi(2) = 3.928, P < 0.05, and chi(2) = 11.512, P < 0.05). The TTF-1 positive rates of the BAC of stage III and nonmucinous type were significantly higher than those of stage I - II and mucinous type respectively (chi(2) = 7.840, P < 0.05, and chi(2) = 19.497, P < 0.05). There was a statistically significant positive correlation between the expression of CK7 and expression of TTF-1 (r = 0.257, P = 0.021). Univariate analysis showed that the main prognostic factors were TTF-1 expression (P = 0.017), clinical stage (P = 0.000), tumor diameter (P = 0.017) and N stage (P = 0.000). Strata analysis suggested that in the nonmucinous type BAC patients the survival time of those positive for TTF-1 expression was superior to those negative for TTF-1 (P = 0.009); and in the stage III BAC patients the survival time of those positive for TTF-1 was superior to those negative for TTF-1 (P = 0.022). Cox regression analysis suggested that TTF-1 (P = 0.035), TNM stage (P = 0.000), tumor diameter (P = 0.034), and N stage (P = 0.000) were independent factors affecting the prognosis., Conclusion: There is a statistically significant positive correlation between the expression of CK7 and the expression of TTF-1. TTF-1 and CK20 provide a new evidence for the molecular staging of BAC. TTF-1, TNM stage, tumor diameter and N stage are all independent factors affecting the prognosis of BAC.