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BackgroundThe course of schizophrenia is prolonged， and patients have impaired social function and significantly reduced quality of life. Drug therapy combined with psychological therapy is particularly important for improving the quality of life of patients. Brief cognitive behavioral therapy （BCBT） has been widely applied in clinical practice， but current research on BCBT focuses more on improving patients' symptoms and lacks relevant reports on improving quality of life.ObjectiveTo evaluate the efficacy and influencing factors of BCBT combined with conventional treatment on improving the quality of life in patients with schizophrenia.MethodsA total of 210 patients who met the diagnostic criteria for schizophrenia in the International Classification of Diseases （10th edition） （ICD-10） and were followed up at the outpatient department of Beijing Anding Hospital Capital Medical University from August 2011 to December 2016 were selected. Using a random number table method， patients were divided into study group and control group， with 105 cases in each group. Both groups received routine treatment， and the research group received a total of 8 BCBT sessions for 12 weeks on this basis. At the baseline period and 12 weeks of treatment， 26 weeks of follow-up and 52 weeks of follow-up， Positive and Negative Syndrome Scale （PANSS）， Personal and Social Performance Scale （PSP） and World Health Organization Quality of Life Brief （WHOQOL-BREF） were used for evaluation.ResultsThe results of repeated measures analysis of variance showed that the time point effect and interaction effect of PANSS total score were statistically significant （F=118.783， 8.083， P

The experiment aimed to investigate the effects of Bacillus subtilis and Enterococcus faecium on the production performance, egg quality, serum biochemical indexes, immune indexes, and intestinal microbes of laying hens. A total of four hundred .38-week-old Hyline Brown laying hens were randomly divided into four groups, with five replicates per group and 20 hens per replicate. Group 1 (control group) were fed with a basic diet. Group 2 received a basic diet supplemented with 200 g/t of Bacillus subtilis. Group 3 received a basic diet supplemented with 200 g/t of Enterococcus faecium. Group 4 received a basic diet supplemented with a composite probiotic consisting of 100 g/t of Bacillus subtilis and 100 g/t of Enterococcus faecium. The experimental period lasted for 56 days. The results showed that compared to the control group, the egg production rate of all the experimental groups increased (P<0.05), and the mortality rate and feed to egg ratio decreased (P<0.05). The eggshell thickness and yolk color increased (P<0.05). The total protein and globulin levels in the serum of laying hens in all the experimental groups increased (P<0.05), and the levels of immunoglobulin G, immunoglobulin M, and y -interferon in the serum all increased (P<0.05). The number of lactic acid bacteria in the cecum chyme of the laying hens increased (P<0.05), while the number of Escherichia coli and Salmonella decreased (P<0.05). The study suggests that Bacillus subtilis and Enterococcus faecium can improve the production performance of laying hens, maintain intestinal health, and enhance serum biochemical and immune indexes. [ABSTRACT FROM AUTHOR]

Objectives: To investigate the incidence rate, clinical characteristics, and prognosis of neonatal stroke in Shenzhen, China., Methods: Led by Shenzhen Children's Hospital, the Shenzhen Neonatal Data Collaboration Network organized 21 institutions to collect 36 cases of neonatal stroke from January 2020 to December 2022. The incidence, clinical characteristics, treatment, and prognosis of neonatal stroke in Shenzhen were analyzed., Results: The incidence rate of neonatal stroke in 21 hospitals from 2020 to 2022 was 1/15 137, 1/6 060, and 1/7 704, respectively. Ischemic stroke accounted for 75% (27/36); boys accounted for 64% (23/36). Among the 36 neonates, 31 (86%) had disease onset within 3 days after birth, and 19 (53%) had convulsion as the initial presentation. Cerebral MRI showed that 22 neonates (61%) had left cerebral infarction and 13 (36%) had basal ganglia infarction. Magnetic resonance angiography was performed for 12 neonates, among whom 9 (75%) had involvement of the middle cerebral artery. Electroencephalography was performed for 29 neonates, with sharp waves in 21 neonates (72%) and seizures in 10 neonates (34%). Symptomatic/supportive treatment varied across different hospitals. Neonatal Behavioral Neurological Assessment was performed for 12 neonates (33%, 12/36), with a mean score of (32±4) points. The prognosis of 27 neonates was followed up to around 12 months of age, with 44% (12/27) of the neonates having a good prognosis., Conclusions: Ischemic stroke is the main type of neonatal stroke, often with convulsions as the initial presentation, involvement of the middle cerebral artery, sharp waves on electroencephalography, and a relatively low neurodevelopment score. Symptomatic/supportive treatment is the main treatment method, and some neonates tend to have a poor prognosis.