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The height,ground diameter,seed yield,medicinal material yield and schaftoside content of Desmodium styracifolium in different fertilization treatment were calculated and compared. The results indicated that fertilization group and no fertilizer group showed significant differences in the terms of growth. The height and medicinal material field of fertilize K 30 g.m-2 was 174.04 cm and 94.5 g,which was the highest among all the fertilize treatment group; The ground diameter of fertilization N 40 g.m-2 was 16.79 mm which was the most coarsest. The combined application of N,P,K significant effected the yield of seed,when N,P,K reached 80 g.m-2,80 g.m-2and 30 g.m-2,the seed yield was highest and the production rate reached to 179.30%; the highest schaftoside content could be reached 0.175% with being N at 40 g.m-2,P at 80 g.m-2and K at 80 g.m-2. It could conclude that the reasonably fertilizing in complex treatment of N,P,K could promote the growth of D. styracifolium and increase the yield,also affected the accumulation of schaftoside. Take height,ground diameter,seed yield,medicinal yield and schaftoside content as evaluation standard. According to the fertilization mathematic model,the optimum fertilizer dosages of N was 42.4-64.5 g.m-2,P: 49.5-59.0 g.m-2,K: 30.0-41.0 g.m-2. The optimum fertilization dosage ratio of N-P-K was 5.4:5.5:3.7. [ABSTRACT FROM AUTHOR]