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Objective To investigate thejob satisfaction and analyze influencing factors of health workers in basic public health service projects. Methods 164 primary medical institutions in Jiangxi Province were selected according to the method of phased cluster sampling. A questionnaire survey was conducted on the health personnel providing basic public health services in these institutions. Nonparametric test and ordered multiclass logistic regression were used to analyze the influencing factors of job satisfaction. Results Among the 3 018 basic public health service workers, the average score of job satisfaction was 24.52 ± 6.84 points. The proportion of very dissatisfied, relatively dissatisfied, average, fairly satisfied and very satisfied were 3.78%, 9.87%, 39.83%, 23.92% and 22.60%, respectively. Multiple linear regression analysis showed that educational background, job category, working years, income, overtime, training and performance reward mechanism had statistical significance on the overall job satisfaction score (P < 0.05). Conclusion The job satisfaction of health worker in basic public health service projects in Jiangxi Province was above average. In order to improve the job satisfaction, we can improve the promotion and guarantee mechanism for grassroots talents, strengthen vocational training, and improve the assessment mechanism. [ABSTRACT FROM AUTHOR]

Objective·To investigate the expression and clinical significance of phospholipase A2 Group IIA (PLA2G2A) in kidney renal papillary cell carcinoma (KIRP), and provide new ideas for seeking KIRP targets. Methods·The expression level of PLA2G2A in pan-cancer and its relationship with prognosis and immune infiltration were analyzed by online software SangerBox. On this basis, the expression level of PLA2G2A in KIRP was analyzed with the help of the UCSC xena database; the correlation between PLA2G2A expression and prognosis and immune infiltration of KIRP were analyzed by using the UALCAN database and the TIMER database, respectively. In addition, the LinkedOmics database was used to analyze the related genes, Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway enrichment of PLA2G2A in KIRP. Results·PLA2G2A was significantly low expressed in 15 tumor samples from The Cancer Genome Atlas (TCGA) including KIRP. It was further validated that PLA2G2A was significantly lower expressed in KIRP with the help of Genotype-Tissue Expression (GTEx) database. The expression level of PLA2G2A was closely related to the prognosis and immune infiltration of various tumors. The higher the expression level of PLA2G2A in KIRP was, the worse the prognosis and the higher the abundance of immune infiltration were. GO analysis showed that PLA2G2A was mainly enriched in biological regulation and metabolic process in biological process (BP), cell membrane and nucleus in cell component (CC), and protein binding and ion binding in molecular function (MF). KEGG pathway enrichment analysis suggested that the pathways positively correlated with PLA2G2A were enriched in ribosome, cell cycle, proteasome, systemic lupus erythematosus and antigen processing and presentation, while the pathways negatively correlated with PLA2G2A were enriched in citrate cycle, pyruvate metabolism, and carbon metabolism. Conclusion· PLA2G2A is significantly lower expressed in KIRP. Unexpectedly, the higher the expression level of PLA2G2A in KIRP is, the worse the prognosis and the higher the abundance of immune infiltration are. In KIRP, the PLA2G2A positively correlated pathways are mainly enriched in cell cycle and immune-related pathways (such as systemic lupus erythematosus, antigen processing and presentation), while the negatively correlated pathways are mainly concentrated in citric acid cycle and pyruvate metabolism signaling pathways. Thus, it is needed to be further explored whether PLA2G2A plays a role in the development of KIRP as a tumor suppressor or an oncogene. [ABSTRACT FROM AUTHOR]