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Antibiotics have fundamentally transformed veterinary and human medicine, being considered as one of the greatest scientific discoveries of the 20th Century. However, due to the environmental persistence and resistance, they have become one of the newly recognized pollutants of widespread concern. In this paper, 23 publications related to antibiotic water quality criteria published before December 31, 2023 were collected through systematic search in CNKI, Wanfang and Web of Science databases. On this basis, we outlined the research status of antibiotic water quality criteria, compared the results of criteria derivation and the toxicity data used, and proposed directions and considerations for future research. The main research conclusions are as follows: Regarding the research subjects, a total of 34 antibiotics water quality criteria for freshwater organisms have been derived, while over 80.00% of antibiotics still require further related studies. It is suggested to prioritize azithromycin, clarithromycin, and levofloxacin for subsequent research. Regarding the highest frequency of antibiotic water quality criteria was obtained using the species sensitivity distribution method (SSD method) and the assessment factor method (AF method), accounting for 48.78% and 3333%, respectively. The antibiotic water quality criteria obtained from the SSD method and the toxicity percentage ranking method (TPR method) are relatively close; hence, the SSD method is recommended as a priority. Regarding toxicity data, algae, invertebrates, and fish are the three most commonly used aquatic organisms for antibiotic toxicity testing. However, the frequency of using fish toxicity data in the derivation of short-term water quality criteria (SWQC) is less than that for long-term water quality criteria (LWQC). There is a noticeable shortage of invertebrate toxicity data used in LWQC derivation compared to SWQC derivation. Therefore, it is recommended to strengthen research on the acute toxicity of fish and the chronic toxicity of invertebrates in the derivation of water quality criteria. [ABSTRACT FROM AUTHOR]

Copyright of Asian Journals of Ecotoxicology is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In recent years, with the worldwide pandemic of corona virus disease 2019 (COVID-19), the safety of anti-infection drugs arouses more and more attention. Hydroxychloroquine alone or combined with azithromycin could cause prolonged QT interval in the ECGs of patients with COVID-19, which may induce severe arrhythmia. According to the clinical evidences reported at home and abroad, the changes of QT interval in COVID-19 patients should be strictly monitored. This paper reviews on the drugs leading to prolonged QT interval, inflammation, age and other factors in COVID-19 patients, and their impact on the prognosis, in order to provide references for clinicians to optimize the treatment options of COVID-19 patients. [ABSTRACT FROM AUTHOR]

Objective: To investigate clinical efficacy of pediatric massage combined with Xiaoer Xiaoji Zhike oral liquid and azithromycin in the treatment of children of mycoplasma pneumoniae pneumonia (MPP) and its effect on immune function and inflammatory factors. Methods: 80 cases of children with MPP who were treated in our hospital from March 2018 to June 2019 were selected. According to the different treatment methods, they were divided into the control group (azithromycin and Xiaoer Xiaoji Zhike oral liquid treatment, n=40) and the study group (pediatric massage, Xiaoer Xiaoji Zhike oral liquid, azithromycin treatment, n=40). The clinical efficacy of the two groups and the improvement of children's symptoms during the treatment were observed, peripheral blood T lymphocyte subsets, adverse reactions and serum inflammatory factors between the two groups were compared. Results: Compared with the control group, the clinical total effective rate of the study group was higher (P<0.05). Compared with the control group, the study group had a shorter of lung rales, cough and X-ray film of lung lesions to disappear time and antipyretic time (P<0.05). Compared with the control group, CD3+, CD4+ and CD4+/CD8+ in the study group was higher at 14 d after treatment, CD8+ was lower (P<0.05). Compared with the control group, interleukin-1β (IL-1β), C-reactive protein (CRP) and interleukin-6 (IL-6) in the study group were lower (P<0.05). There was no significant difference in incidence of adverse reactions in two groups (P>0.05). Conclusion: Pediatric massage combined with Xiaoer Xiaoji Zhike oral liquid and azithromycin in the treatment of children with MPP can promote the improvement of symptoms, optimize the clinical treatment effect, and effectively regulate the immune function and inflammatory factor levels of children. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Preventive Veterinary Medicine / Zhongguo Yufang Shouyi Xuebao is the property of Chinese Journal of Preventive Veterinary Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)