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The QuEChERS method is fast, simple, inexpensive, efficient, and safe, and is widely regarded as a reliable analytical method, making significant progress in pesticide residue analysis. The QuEChERS method can effectively analyze other compounds, including drugs and fungal toxins in various complex matrices. This paper provides an overview of the origin and research process of the QuEChERS method, as well as its application and optimization in fields such as pesticides, drugs, toxins, etc., providing reference for the application and development of the QuEChERS method. [ABSTRACT FROM AUTHOR]

BACKGROUND: Combining drugs with materials using 3D printing technology can be formulated into a dosage form with a specific release rate, which is better for clinical use. OBJECTIVE: To review the preparation technique, advantages and indications of pharmaceutical composites made from western medicine, traditional Chinese medicine, metal elements and ions and related materials. METHODS: The first author used the search terms "Drug; Chinese medicine; Metal; Composite materials; 3D printing" to search the CNKI and Wanfang databases in Chinese and the PubMed and Web of Science in English to retrieve papers published during 1950-2019. A total of 339 papers were preliminarily retrieved. After screening, 46 papers were included in the final analysis. RESULTS AND CONCLUSION: Pharmaceutical composite materials made of western medicine, traditional Chinese medicine, metal elements and ions and related materials have certain advantages in the pharmaceutical field and clinical use. It can not only improve the bioavailability of drugs, reduce toxic side effects, but also achieve a combination of drugs. In recent years, drug composite materials have been used in orthopedics, dentistry, cardiovascular medicine, otolaryngology and other fields, but its application is still in its infancy. Many aspects need to be improved, such as improving the quality of drug composites, increasing mechanical stability, reducing the brittleness, printing the full-featured blood vessels and organs that fit the size of the human body, and better imitating the biomechanics and tissue structure of human body. [ABSTRACT FROM AUTHOR]

In recent years, China's anti-tumor drugs has shown a continuous growth trend, and the activity of antitumor research and development in China accounts for a higher proportion in the world. However, further analysis of research and development hotspots show that the research and development of anti-tumor drugs is uneven among different tumor types. Due to the small number of the patients, it is difficult to conduct clinical trials, resulting in less drug development in the field of rare tumors. However, patients' treatment needs will also bring potential opportunities for pharmaceutical companies. The development of basic research and the discovery of new molecular tumor typing make "rare tumors" a dynamic concept. The scope of "rare tumors" may gradually expand with the precise development of treatment; or as the knowledge of tumors gradually develops from histocytology to the molecular level, It is possible that certain tumors with specific mutations can be combined into a group of non-rare "pan-tumors". Rare tumors are characterized by both rare diseases and tumors. Its drug research and development should not only meet the requirements of tumor drug research and development, but also adapt to the characteristics of rare diseases. Therefore, in the drug research and development, we can refer to the research and development principle of rare disease drugs, combine with the characteristics of tumor diseases, make full use of non-rare tumor clinical trials, make full use of scientific tools and exquisite trial design, and realize the promotion of the research and development of rare tumor drugs. This paper will summarize the thoughts in the review of new drugs in the field of rare tumors, in order to provide guidance for the industry. [ABSTRACT FROM AUTHOR]

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Identification of potential drug-target interactions is critical for drug research. Based on the label propagation algorithm, this paper proposed a new strategy which integrated the information of heterogeneous network for identification of drug-target interaction. Firstly, it calculated the similarity between all drugs and similarity between all targets, it integrated three different networks into a heterogeneous network by the known drug-target interactions. Then it implemented the modified label propagation on drug-drug similarity and target-target similarity network alternately with mutual interaction information derived from the heterogeneous network. Finally, it applied extensively testing to four datasets. Through comparison with other recently proposed BLM-NII and NRWRH, this algorithm attained high ROC and PR curve area and was capable of predicting more reliable DTIs. [ABSTRACT FROM AUTHOR]

This paper summarized the strategy for applying utility model patents in clinical nursing. Issues about meaning of patent, application procedure and design inspiration were discussed and shared, in order to provide reference in design and application of utility model patents for clinical nurses. (本文总结临床护理用具实用新型专利申请过程中的相关经验, 包括专利的含义、专利申请流程、专利设计灵感等, 希望以此为广大临床护理工作者在研发和申请专利方面提供可靠参考。)