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Objective: To study the expression and clinical significance of Bcl -2, BAG -1, Ki -67, ER and PR on premenopausal and postmenopausal endometrial polyps. Methods: The expression of Bcl-2, BAG-1, Ki-67, ER and PR in 30 cases premenopausal endometrial polyps and 30 cases postmenopausal endometrial polyps tissues were detected by immunohistochemistry. Results: Bcl-2, BAG-1 and Ki-67 were higher expression in endometrial polyps than control group (P< 0.05), but no signification difference among ER and PR expression(P>0.05). Ki-67 expression in postmenopausal endometrial polyps was significantly lower than premenopausal endometrial polyps tissues (P<0.05). There were no signification difference among Bcl-2, BAG-1, ER and PR expression between premenopausal and postmenopausal endometrial polyps (P>0.05). Correlation analysis showed that Ki-67 was positively correlated with PR on postmenopausal endometrial polyps (P<0.05), and there was no correlation among other groups (P>0.05). Conclusions: Bcl-2, BAG-1, Ki-67, ER and PR may play an important role at different period of endometrial polyps pathological changes. [ABSTRACT FROM AUTHOR]

Objective: To compare the change of the level of the vascular endothelial growth factor (VEGF) in aqueous humor of patients with neovascular glaucoma (NVG) before and after anterior retinal cryotherapy and investigate the effects of the fluctuation of VEGF on the neovascularization of iris., Methods: 28 patients with neovascular glaucoma were undergone iris fluorescent angiography to identify the area and amount of new vessels before and after anterior retinal cryotherapy. The neovascularization of iris was observed from 7 to 14 days by iris fluorescent angiography to confirm the regression of new vessels in iris before trabeculectomy. Samples of aqueous humor were obtained before anterior retinal cryotherapy and trabeculectomy, and 30 samples of aqueous humor from patients with senile cataract were collected as normal group. The concentrations of VEGF were measured using enzyme linked immunosorbent assay., Results: the concentration of VEGF (2.096 +/- 0.512) ng/ml in aqueous humor from patients with NVG were much higher than the specimen from the patients pre-trabeculectomy (0.478 +/- 0.312) ng/ml, There was a significant difference between the two groups (t = 17.994, P < 0.01). The mean VEGF concentration of the aqueous humor from patients with senile cataract was (0.198 +/- 0.045) ng/ml which was much lower compared with the samples from patients of pre-trabeculectomy (t = 18.453, P < 0.01)., Conclusions: The concentration of VEGF decline after the regression of new vessels in iris. The results suggest that VEGF play an important role in formation of iris neovascularization. Blockage the release of VEGF might reduce the occurrence of neovascular glaucoma.

Objective: To observe changes of retinal thickness after photodynamic therapy (PDT) for patients with subfoveal choroidal neovascularization (CNV), and evaluate the effect of retinal edema after PDT., Methods: PDT was performed on 27 eyes of 25 patients with subfoveal CNV, the spot diameter of laser beam was 1.8 - 4.3 mm (average 2.9 mm), OCT was used to evaluate the changes of retinal thickness including the retinal thickness of macular fovea and 3 mm laser radiating zone 24 hour 1 week, 1 month, 3 month after PDT. Retinal thickness was compared before PDT and 24 h, 1 week, 1 month, 3 month after PDT respectively., Results: Retinal thickness of fovea before PDT and 24 h, 1 week, 1 month, 3 month was (278.07 +/- 85.31), (324.52 +/- 96.08), (242.74 +/- 67.40), (234.26 +/- 51.04) microm and (239.73 +/- 52.81) microm respectively, the average retinal thickness of 3 mm laser radiating zone was (266.71 +/- 60.82), (309.25 +/- 82.69), (257.48 +/- 52.48), (245.44 +/- 47.54) microm and (244.88 +/- 44.22) microm respectively. There was statistical significance before PDT compared with 24 h, 1 month, 3 month after PDT (P < 0.01)., Conclusions: The result of our study indicate that retinal thickness of laser radiating zone increases apparently 24 h after PDT and regresses during the first week. It suggest that retinal edema after PDT may due to the leakage from the CNV, increased permeability in choroid and retina of laser radiating zone, and transient dysfunction of retinal pigment epithelial cells.

Objective: To investigate the relation of the visual function recovery and the postoperative form of the idiopathic macular holes., Methods: 38 eyes with macular holes which were closed after one surgery were selected and were grouped into type of complete healed, partial healed and no healed by Optical Coherent Tomography (OCT). Scanning Laser Ophthalmoscope (SLO) examination were performed preoperatively and 1 month, 3 months and 6 months postoperatively to detect the sensitivity, areas of absolute scotoma, relative scotoma and central visual acuity., Results: Among type of complete healed group and type of partial healed group 6 months after vitrectomy the central vision, sensitivity, areas of absolute scotoma and relative scotoma had statistical significant improvement. The central vision and sensitivity improved postoperatively and areas of absolute scotoma and relative scotoma had no significant changes in type of no healed group. The extent of improvement of vision, sensitivity, absolute scotoma in type of complete healed group was more greater than type of partial healed group and no healed group. The fovea configuration of stage II macular holes was easier to recover completely., Conclusions: The recovery of the normal curvature of macular fovea is positive to the improvement of the visual function. The better the fovea contour recover, the more significantly the visual function improve. The early stage of macular holes (stage II) could get better improvement of visual function.