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Objective To explore the correlation between metabolic syndrome (MS) and noise-induced hearing loss (NIHL) in noise-exposed workers. Methods Using the convenient sampling method, a total of 850 male noise-exposed workers in an automobile manufacturing enterprise were studied. The questionnaire survey and occupational health examination were combined to collect general demographic data, physical examination data, and other information. According to the results of high-frequency hearing loss, the noise-exposed workers were divided into the hearing loss group (326 workers) and the normal hearing group (524 workers). The single-factor analysis was used to compare the above data differences between the two groups. The binary multiple-factor logistic regression model was used to analyze the influencing factors of NIHL in noise-exposed workers. Results The non-compliance rate of noise intensity in the enterprise was 39.47% (15/38), with the highest occurrences in the welding and painting posts. The morbidity of hearing loss was 38.35% (326/850), and the MS morbidity was 27.53% (234/850). The frequency of obesity, high-level triglyceride, high-level fasting blood glucose, hypertension, MS,and the contact noise level in the hearing loss group were higher than those in the normal hearing group (P < 0.05). The results of multiple-factor logistic regression showed that, compared with the workers with a noise exposure duration ≤ 5 years, the risk of NIHL in the workers with a noise exposure duration of 11 - 15 years or > 15 years increased to 1.553 and 1.727 times, respectively (P < 0.001). Compared with the workers without MS, the risk of NIHL in the workers with MS increased to 1.863 times (P < 0.001). The risk of NIHL increases by 1.567 times for each 1 dB(A) increase in noise level (P < 0.001). Conclusions There was a correlation between MS and NIHL. In addition to emphasizing control of noise level in the workplace, attention should also be paid to adopting a low-sugar, low-salt, and low-sodium diet, reducing the intake of saturated fatty acids, and strengthening physical exercise to effectively control the blood pressure, blood sugar, and blood lipid levels of workers so as to reduce the risk of NIHL. [ABSTRACT FROM AUTHOR]

Objective: To investigate the bionomics of the olfactory ensheathing cells (OECs) of human olfactory mucosa., Method: To separate and cultivate the OECs of human and rat olfactory mucosa. To observe the cell growth, cell grouping and cell migration in vitro of the two types of OECs., Result: Successfully separated and cultivated the OECs of human and rat olfactory mucosa. OECs of the human and rat olfactory mucosa had the similar cell growth, cell grouping and cell migration ability in vitro., Conclusion: OECs of the human and rat olfactory mucosa have the similar bionomics in vitro, as a result, OECs of the human olfactory mucosa could be a reliable source of cell transplant for nerve injury.

Objective: To explore the expression of mycoplasma monoclonal antibody PD4 in different laryngeal carcinoma tissues and their clinical significance., Method: Using immunohistochemistry methods to detect 256 cases of laryngeal tissues, including 105 cases of laryngeal carcinoma tissues, 31 cases of neck metastasis lymph node tissues, 18 cases of precarcinoma tissues, 53 cases of vocal cord polyps, 20 cases of normal tissues adjacent to laryngeal carcinoma and 29 cases of normal tissues around laryngeal carcinoma., Result: (1) The positive rate of PD4 was 44.76% in laryngeal carcinoma, which was much higher than that in other laryngeal tissues (P < 0.01 or P < 0.05). (2) The PD4 expression in laryngeal carcinoma was higher in the third and fourth stages than in the first and second stages, higher with cervical metastasis than those without cervical metastasis and higher in the third and second histological grade than in the first histological grade (P < 0.01 or P < 0.05). (3) To 3 and 5 years survival, PD4 positive cases had lower chance than PD4 negative cases (P < 0.01)., Conclusion: These results implicate that the occurrence, development and prognosis of laryngeal carcinoma may be closely related to mycoplasma infection.

Objective: To study the expression of PD4, CD44 and PCNA proteins in laryngeal carcinoma and their relationships with the pathogenesis, development and prognosis of laryngeal carcinoma., Method: Immunohistochemistry was used to study 140 cases of laryngeal carcinoma tissues, 25 cases of precarcinoma tissues, 36 cases of vocal cord polyps and 13 cases of normal tissues adjacent to laryngeal carcinoma., Result: 1. The positive rates of PD4, CD44 and PCNA were 45.71% (64/140), 64.29% (90/140) and 77.86% (109/140) in laryngeal carcinoma, which were much higher than in non-carcinoma tissues (P < 0.01). 2. The third and fourth stages laryngeal carcinoma express stronger PD4 and CD44 than those of the first and second stages. Laryngeal carcinoma with cervical metastasis had higher expression than those without cervical metastasis. To 3 and 5 years' survival, PD4, CD44 and PCNA positive cases had lower chance than those negative cases(P < 0.01 or 0.05). 3. The over all positive rate of PD4, CD44 and PCNA was 27.86% (39/140) in laryngeal carcinoma tissues and 5.41% (4/74) in non-carcinoma tissues., Conclusion: The high expression of PD4, CD44 and PCNA proteins maybe closely related to the pathogenesis, development and prognosis of laryngeal carcinoma.

Objective: Study on the role of mycoplasma infection and expression of CD44v6, CD44v9 protein in the pathogenesis, development and prognosis of laryngeal carcinoma (LC)., Method: Immunohistochemistry was used to study 137 cases of laryngeal carcinoma tissues, 26 cases of precarcinoma tissues, 34 cases of vocal cord polypus and 15 cases of normal tissues adjacent to laryngeal carcinoma., Result: The positive rate of PD4 and CD44v6, CD44v9 was 45.3% (62/137), 72.3% (99/137) and 56.2% (77/137) in laryngeal carcinoma, which are much higher than those in non-carcinoma tissues. (2) The positive rate of PD4 and CD44v6. CD44v9 in the third and fourth stages of LC were higher than those in the first and second stages of LC. Laryngeal carcinoma with cervical metastasis had higher expression than those without cervical metastasis (P < 0.01). To 3 and 5 years survival, PD4 and CD44v6, CD44v9 positive cases had lower chance than those negative cases (P < 0.01 [Chinese character: see text] 0.05). (3) The overall positive rate of PD4 and CD44v6, CD44v9 was 27.7% (38/137) in laryngeal carcinoma tissues and 5.3% (4/75) in non-carcinoma tissues., Conclusion: These results implicates that the pathogenesis, development and prognosis of laryngeal carcinoma maybe closely related to the high expression of PD4 and CD44v6, CD44v9 protein.

Objective: To explore the CD44 expression in different laryngeal carcinoma tissues and their clinical significance., Method: Using immunohistochemistry methods to study 261 cases of archived paraffin-embedded laryngeal tissue., Result: The results turned out to be as follows: 1. A high level of CD44 expression was more frequently found in laryngeal carcinoma than in precarcinoma lesions and normal tissues. 2. CD44 expression correlated well with histological grades, the higher grade the lower the CD44 expression. 3. The third and fourth stages laryngeal carcinoma had stronger CD44 positive than those of the first and second stages. 4. CD44 expression in laryngeal carcinoma with cervical metastasis were higher than those without cervical metastasis. 5. To 3 and 5 years survival, CD44 positive cases had lower chance than CD44 negative cases., Conclusion: These results implicates that the occurrence, development and prognosis of laryngeal carcinoma may be closely related to CD44 expression.

Objective: To study the expression of intercellular adhesion molecules in turbinate mucosa of allergic rhinitis and its significance., Method: Samples of turbinate mucosa were from 20 cases of chronic hypertrophic rhinitis, 24 cases of non provocation period allergic rhinitis and 20 cases of provocation period allergic rhinitis and their paraffin sections were studied with immunohistochemical technique staining with ICAM 1 and LFA 1 monoclone antibodies., Result: Expression of ICAM 1 and LFA 1 were higher in turbinate mucosa of provocation period allergic rhinitis than in chronic hypertrophic rhinitis and non provocation period allergic rhinitis turbinate mucosa(P < 0.01)., Conclusion: High expression of ICAM 1 and LFA 1 in turbinate mucosa of allergic rhinitis shows that the interaction of ICAM-1/LFA-1 may participate in the inflammatory reaction of allergic rhinitis and may play an important role in the pathogenesis and development of allergic rhinitis.

Objective: Observing the voice recovery rule of vocal polyp in 20 cases to give the reasonable voice method for the patients after operation., Method: Follow up the voice changes by means of voice assessment for 2 weeks after the operation., Result: The worst voice of the patients occurred in the day 1 after the operation. It recovered significantly in day 10(P < 0.05) and reached to normal status in day 14(P < 0.01)., Conclusion: The patients with vocal polyp should be in rest of voice for at least 2 weeks after the operation.